Hyperbranched polymer and preparation method and application thereof

A technology of hyperbranched polymers and hyperbranched polyurethanes, applied in the field of nanomaterials, can solve the problems of narrow molecular weight distribution of hyperbranched polyurethanes, inability to be used as drug carriers, and inability to form micelles, etc., to improve bioavailability and biological activity, Wide applicability, improving the effect of drug loading

Inactive Publication Date: 2011-07-27
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

GPC measurement shows that the molecular weight distribution of the synthesized hyperbranched polyurethane is narrow and has monodispersity; the viscosity is lower than that of linear molecules with the same molecular weight; the heat resistance is better, and the weight loss temperature is higher than 200 ° C. The formed hyperbranched polyurethane cannot form micelles and cannot Used as a drug carrier

Method used

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  • Hyperbranched polymer and preparation method and application thereof
  • Hyperbranched polymer and preparation method and application thereof
  • Hyperbranched polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Preparation of hyperbranched polyurethane

[0046] A. Preparation of N, N-dihydroxyethyl-3-aminomethyl acrylate monomer

[0047] Add 8.609g methyl acrylate, 10.514g diethanolamine and 10ml methanol mixture in the there-necked flask, at room temperature and logical N 2 Stir for 30 minutes under normal conditions, then heat up to 40 ° C for 4 hours, and then remove excess methyl acrylate and methanol through vacuum distillation to obtain a colorless and transparent oily liquid, namely, N, N-dihydroxyethyl-3-amino Methyl acrylate monomer.

[0048] B. Preparation of the second generation hyperbranched polyurethane polymer

[0049] Add 1.342g 1,1,1-trimethylolpropane, 5.93g N,N-dihydroxyethyl-3-aminomethyl acrylate monomer and 0.017g tetraisobutoxytitanium in the there-necked flask as catalyst , the reaction system at N 2 Under protection, the reaction was carried out at a constant temperature of 120°C for 12 hours to obtain a yellow viscous liquid. Dissolve the crud...

Embodiment 2

[0058] 1. Preparation of hyperbranched polyurethane

[0059] A. Preparation of N, N-dihydroxyethyl-3-aminomethyl acrylate monomer

[0060] In the there-necked flask, add 8.609g methyl acrylate, 10.514g diethanolamine and 10ml methanol, the mixture is at room temperature and logical N 2 Under normal circumstances, stir for 30 minutes, then heat up to 40 ° C for 4 hours, and then remove excess methyl acrylate and methanol through vacuum distillation to obtain a colorless and transparent oily liquid N, N-dihydroxyethyl-3-aminomethacrylate ester monomer.

[0061] B. Preparation of the second generation hyperbranched polyurethane

[0062] Add 1.342g 1,1,1-trimethylolpropane, 15.93g N,N-dihydroxyethyl-3-aminomethyl acrylate monomer and 0.017g tetraisobutoxytitanium in the three-necked flask as catalyst , the reaction system at N 2 Under protection, the reaction was carried out at a constant temperature of 120°C for 12 hours to obtain a yellow viscous liquid. Dissolve the crude ...

Embodiment 3

[0068] 1. Preparation of hyperbranched polyurethane

[0069] A. Preparation of N, N-dihydroxyethyl-3-aminomethyl acrylate monomer

[0070] Add 8.609g methyl acrylate, 10.514g diethanolamine and 10ml methanol mixture in the there-necked flask, at room temperature and logical N 2 Under normal circumstances, stir for 30 minutes, then raise the temperature to 40 ° C for 4 hours, and then remove excess methyl acrylate and methanol through vacuum distillation to obtain a colorless and transparent oily liquid N, N-dihydroxyethyl-3-aminoacrylic acid Methyl ester monomer.

[0071] B. Preparation of the second generation hyperbranched polyurethane polymer

[0072] Add 1.342g 1,1,1-trimethylolpropane, 15.93g N,N-dihydroxyethyl-3-aminomethyl acrylate monomer and 0.017g tetraisobutoxytitanium in the three-necked flask as catalyst , should be system in N 2 Under protection, the reaction was carried out at a constant temperature of 120°C for 12 hours to obtain a yellow viscous liquid. D...

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Abstract

The invention provides a hyperbranched polymer and a preparation method and application thereof. The polymer has a structure shown as the following formula (I), wherein n is a positive integer from 1 to 5; B is aliphatic polyester; and the molecular weight of the polymer is between 4,000 kDa and 7,000 kDa. The invention also provides the method for preparing the polymer and a micelle formed by the polymer and a method for preparing the micelle. The micelle prepared by the polymer can be used for a medicament carrier material and has good biocompatibility; as the critical micelle concentrationCMC is quite low and the formed micelle is stable and has small particle diameter and long circulation, the polymer micelle can be used for coating various hydrophilic and hydrophobic medicaments andis a medicament carrier with development prospect.

Description

technical field [0001] The invention relates to a hyperbranched polymer, a preparation method thereof, a micelle formed by the polymer, a preparation method and an application of the micelle. Specifically, the invention relates to a hyperbranched polyurethane-aliphatic polyester capable of forming micelles, which belongs to the technical field of nanomaterials. Background technique [0002] Dendritic macromolecules are a kind of dendritic macromolecules with high regularity and three-dimensional structure. Drugs and targeting groups, by modifying the surface of different polymers with different functional groups, can make the surface hydrophilic and increase biocompatibility. Through the construction reaction, a huge hydrophobic space can be formed inside the dendrimer. Due to the hydrophilic surface structure of dendrimers, the internal cavity and binding points can carry drugs, so this provides unique conditions for dendrimers as drug carriers, which can realize the true...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/685C08G73/02C08G63/91C08J3/03A61K47/34
Inventor 吴雁蒋明
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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