Hyperbranched polymer and preparation method and application thereof

A technology of hyperbranched polymers and hyperbranched polyurethanes, applied in the field of nanomaterials, can solve the problems of narrow molecular weight distribution of hyperbranched polyurethanes, inability to be used as drug carriers, and inability to form micelles, etc., to improve bioavailability and biological activity, Wide applicability, improving the effect of drug loading
CN101628970BInactive Publication Date: 2011-07-27THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2011-07-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a hyperbranched polymer and a preparation method and application thereof. The polymer has a structure shown as the following formula (I), wherein n is a positive integer from 1 to 5; B is aliphatic polyester; and the molecular weight of the polymer is between 4,000 kDa and 7,000 kDa. The invention also provides the method for preparing the polymer and a micelle formed by the polymer and a method for preparing the micelle. The micelle prepared by the polymer can be used for a medicament carrier material and has good biocompatibility; as the critical micelle concentrationCMC is quite low and the formed micelle is stable and has small particle diameter and long circulation, the polymer micelle can be used for coating various hydrophilic and hydrophobic medicaments andis a medicament carrier with development prospect.
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Description

technical field

[0001] The invention relates to a hyperbranched polymer, a preparation method thereof, a micelle formed by the polymer, a preparation method and an application of the micelle. Specifically, the invention relates to a hyperbranched polyurethane-aliphatic polyester capable of forming micelles, which belongs to the technical field of nanomaterials. Background technique

[0002] Dendritic macromolecules are a kind of dendritic macromolecules with high regularity and three-dimensional structure. Drugs and targeting groups, by modifying the surface of different polymers with different functional groups, can make the surface hydrophilic and increase biocompatibility. Through the construction reaction, a huge hydrophobic space can be formed inside the dendrimer. Due to the hydrophilic surface structure of dendrimers, the internal cavity and binding points can carry drugs, so this provides unique conditions for dendrimers as drug carriers, which can realize the true...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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