Acne ointment as well as preparation method and quality detection method thereof

A quality inspection method and ointment matrix technology, which can be used in ointment delivery, measuring devices, pharmaceutical formulations, etc., and can solve problems such as inconvenient use

Active Publication Date: 2010-03-10
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Add soybean powder and prescription drugs to Jiawei Dianduosan to prepare ointment. Soy contains more nutrients such as starch and amino acids. After combining with water, bacteria are easy to grow in this environment, so the preparation prepared by this method Generally, it is ready-to-use, which is extremely inconvenient to use

Method used

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  • Acne ointment as well as preparation method and quality detection method thereof
  • Acne ointment as well as preparation method and quality detection method thereof
  • Acne ointment as well as preparation method and quality detection method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0113] Embodiment 1 of the present invention: preparation of acne ointment:

[0114] Take 25g each of sulfur and rhubarb, crush them into very fine powder, grind them evenly with a small amount of glycerin, and set aside; take another 120g of stearic acid, 40g of glyceryl monostearate, 194g of castor oil and 1g of ethyl p-hydroxybenzoate, and put them in a container heat and melt at 50-60°C to obtain an oil phase, keep warm for later use; then take 100g of glycerin, 15g of triethanolamine, and 480g of water, put them in another container, heat and melt at 50-60°C to obtain a water phase; Slowly add to the water phase, stir continuously, mix well, let cool to room temperature, make cream base, then mix with the above-mentioned medicinal powder evenly, grind to make fine ointment 1000g, pack separately, and obtain the acne cream according to the present invention ointment. The ointment is for external use, smeared on the affected part, 2-3 times a day.

Embodiment 2

[0115] Embodiment 2 of the present invention: preparation of acne ointment:

[0116] Take 20g each of sulfur and rhubarb, crush them into very fine powder, grind them evenly with a small amount of glycerin, and set aside; take another 120g of stearic acid, 40g of glyceryl monostearate, 194g of castor oil and 1g of ethyl p-hydroxybenzoate, and put them in a container heat and melt at 50-60°C to obtain an oil phase, keep warm for later use; then take 100g of glycerin, 15g of triethanolamine, and 480g of water, put them in another container, heat and melt at 50-60°C to obtain a water phase; Slowly add it into the water phase, stir continuously, mix well, let it cool to room temperature, and make a cream base, then mix it with the above-mentioned medicinal powder evenly, grind it to make an ointment, and pack it separately to get an acne ointment. The ointment is for external use, smeared on the affected part, 2-3 times a day.

Embodiment 3

[0117] Embodiment 3 of the present invention: the quality detection method of acne ointment of the present invention comprises:

[0118] Identification: (1) Take 2.5g of this ointment, add 20ml of water, heat to dissolve, let cool, discard the supernatant, add 20ml of water, heat to dissolve, filter with No. Burning on the flame, the flame is blue, and has a special pungent smell of sulfur dioxide.

[0119] (2) Take 4g of this ointment, add 30ml of methanol, sonicate for 20 minutes, filter, take 5ml of the filtrate, evaporate to dryness, add 10ml of water to the residue to dissolve, add 1ml of hydrochloric acid, heat in a water bath for 30 minutes, cool immediately, and wash with ether Divide into 2 extractions, 20ml each time, combine the ether solution, evaporate to dryness, add 1ml of chloroform to the residue to dissolve, and use it as the test solution; take another 0.1g of rhubarb reference drug, and make the reference drug solution in the same way; then take rhein For ...

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Abstract

The invention discloses an acne ointment as well as a preparation method and a quality detection method thereof. According to parts by weight, the acne ointment is made from 0.8-1.2 parts of sulfur, 0.8-1.2 parts of rhubarb, 5-7 parts of stearic acid, 1-3 parts of glyceryl monostearate, 7-11 parts of castor oil, 0.04-0.06 part of ethyl p-hydroxybenzoate, 4-6 parts of glycerol, 0.7-0.8 part of triethanolamine and 20-28 parts of water. Compared with the prior art, the acne ointment has the efficacies of clearing way heat and removing toxicity, eliminating dampness and killing insects, can prevent and treat acne comprehensively, and is characterized by convenient carrying-over and use, comfort, obvious curative effect and less toxic side effects; and the quality detection method has strong specificity, high precision and good stability, and can effectively ensure the clinical treatment efficacy of the acne ointment.

Description

Technical field: [0001] The invention relates to an acne ointment, a preparation method and a quality detection method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Acne is commonly known as acne and pimples. It is a chronic skin inflammation that occurs mostly in adolescents. According to the prevalence survey of acne in recent years, the incidence rate of adolescents aged 11-25 reaches more than 80%, and the incidence rate of young people aged 25-35 reaches 80%. More than 15%, if not treated in time or improperly prevented and treated, scars that are difficult to heal can be left over for life, which will affect the appearance and make many young patients very distressed. [0003] The main cause of acne is that puberty matures, and the level of androgen in the body increases, which stimulates the epithelial cells that sebum and hair follicles shed, and aggregates into yellowish-white substances that emb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/06A61K47/44A61P17/10G01N30/90G01N31/16G01N33/15A61K33/04
Inventor 周方勇
Owner GUIZHOU BAIHUA PHARMA
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