Wound repair hydrogel material and preparation method thereof

A wound repair and hydrogel technology, which is used in medical science, bandages, absorbent pads, etc., can solve problems such as gel brittleness, reduced water retention capacity, and reduced wound exudate capacity, and achieves a simple preparation process and good antibacterial properties. Sex, simple formula effect

Inactive Publication Date: 2010-03-10
都本立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthesizing hydrogel dressings by freeze-thaw method does not have the problem of using cross-linking agents and initiators, but the hydrogel dressings synthesized by this method are opaque, which is not conducive to wound observation and long-term storage, and has thermal reversibility. It is easy to deform when the temperature is high, making it difficult to transport and store, and the process of freezing and thawing will easily cause the water in the hydrogel dressing to overflow, resulting in a greatly reduced water retention capacity and a reduced ability to absorb wound exudate, thus affecting the wound. Nursing effect, not easy to adhere to the skin
The radiation method is usually used to prepare medical hydrogels, but the mechanical strength of the hydrogels prepared by the radiation method is low, especially when a single raw material is used for irradiation, the resulting gel is relatively brittle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] [Example 1] Mix 15g of polyvinyl alcohol, 3g of polyvinylpyrrolidone, 2g of chitosan quaternary ammonium salt, and 100g of water, heat it in a water bath at 90°C to make a mixed aqueous solution, ultrasonic defoaming, and pour the aqueous solution into a mold at 4°C Under certain conditions, the solution was self-crosslinked and solidified for 24 hours. The thickness of the wound repairing hydrogel material prepared by the mold was 0.5mm, which was packed into a bag and sealed, and irradiated with an electron beam of 25KGy. The crosslinking and sterilization were completed simultaneously.

[0022] The hydrogel material has a water content of 79% and an extensibility of 2N cm -1 , the permanent deformation is 2%, the antibacterial zone of Staphylococcus aureus and Escherichia coli is greater than 7mm, and has antibacterial properties.

Embodiment 2

[0023] [Example 2] Mix 15g of polyvinyl alcohol, 1g of sodium alginate, 3g of chitosan quaternary ammonium salt, and 100g of water, heat it in a water bath at 90°C to make a mixed aqueous solution, ultrasonic defoaming, and pour the aqueous solution into a mold at 10°C Under certain conditions, the solution was self-crosslinked and solidified for 72 hours. The thickness of the wound repairing hydrogel material prepared by the mold was 10mm. The bag was sealed, and cobalt-60 was irradiated with 40KGy, and the crosslinking and sterilization were completed simultaneously.

[0024] The hydrogel material has a water content of 75% and a stretchability of 3N cm -1 , the permanent deformation is 1.5%, and the antibacterial zone of Staphylococcus aureus and Escherichia coli is greater than 7mm, which has antibacterial properties.

Embodiment 3

[0025] [Example 3] 10g of polyvinyl alcohol, 1g of polyvinylpyrrolidone, 3g of sodium alginate, 2g of chitosan quaternary ammonium salt, and 100g of water are mixed, heated in a water bath at 90°C to make a mixed aqueous solution, ultrasonically defoamed, and the aqueous solution is poured on In the mold, at 0°C, the solution was self-crosslinked and solidified for 24 hours. The thickness of the wound repairing hydrogel material prepared by the mold was 5.0 mm. The bag was sealed, and the electron beam was irradiated with 18KGy. The crosslinking and sterilization were completed simultaneously.

[0026] The hydrogel material has a water content of 75% and a stretchability of 2N cm -1 , the permanent deformation is 1.5%, and the antibacterial zone of Staphylococcus aureus and Escherichia coli is greater than 7mm, which has antibacterial properties.

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Abstract

The invention relates to a wound repair hydrogel material, composed of the following components by parts by weight: 10-20 parts of synthesized hydrophilic polymer compound, 2-6 parts of chitosan quaternary ammonium salt and 100 parts of water. The preparation method of the wound repair hydrogel material includes that raw materials are heated and dissolved according to prescription requirement andthen are subject to standing or ultrasound defoaming, solution is poured into a specific mould, the mould is horizontally placed under the condition of 0-20 DEG C, self crosslinking is carried out for1-7 days, sealing is carried out, cobat-60 or electron accelerator is used for irradiation, and irradiation dosage is 10-100KGy. The prescription of the invention has the advantages that: the prescription is safer and more efficient, chitosan quaternary ammonium salt can be directly fused with other components without adding acid, thus preparation process is simper. The preparation method of theinvention has the advantage that: the obtained wound repair hydrogel material has both good flexibility and high transparency, thus being convenient for medical care personnel to observe wound surface.

Description

technical field [0001] The invention relates to the chemical aspects of medical bandages, dressings or absorbent pads, in particular to a wound repairing hydrogel material composed of macromolecular materials and a preparation method. Background technique [0002] Studies have confirmed that wounds heal twice as fast in a moist environment than in a dry environment, that is, the "moist healing concept". Based on this concept, hydrogel dressings have been developed. At present, this concept has been widely used in the care of various wounds including surgical incisions, burns, pressure sores, infected wounds, and chronic refractory wounds. Compared with the traditional dry healing method, wet healing has the following advantages: 1. Regulating the oxygen tension of the wound surface, promoting the formation of capillaries; 2. Facilitating the dissolution of necrotic tissue and fibrin; 3. Promoting the release of various growth factors, these Growth factors play a very import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/24A61L15/20A61L15/46A61L15/62
Inventor 姜红杨毅都本立朱锐
Owner 都本立
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