Wound repair hydrogel material and preparation method thereof

Abstract

The invention relates to a wound repair hydrogel material, composed of the following components by parts by weight: 10-20 parts of synthesized hydrophilic polymer compound, 2-6 parts of chitosan quaternary ammonium salt and 100 parts of water. The preparation method of the wound repair hydrogel material includes that raw materials are heated and dissolved according to prescription requirement andthen are subject to standing or ultrasound defoaming, solution is poured into a specific mould, the mould is horizontally placed under the condition of 0-20 DEG C, self crosslinking is carried out for1-7 days, sealing is carried out, cobat-60 or electron accelerator is used for irradiation, and irradiation dosage is 10-100KGy. The prescription of the invention has the advantages that: the prescription is safer and more efficient, chitosan quaternary ammonium salt can be directly fused with other components without adding acid, thus preparation process is simper. The preparation method of theinvention has the advantage that: the obtained wound repair hydrogel material has both good flexibility and high transparency, thus being convenient for medical care personnel to observe wound surface.

Description

technical field [0001] The invention relates to the chemical aspects of medical bandages, dressings or absorbent pads, in particular to a wound repairing hydrogel material composed of macromolecular materials and a preparation method. Background technique [0002] Studies have confirmed that wounds heal twice as fast in a moist environment than in a dry environment, that is, the "moist healing concept". Based on this concept, hydrogel dressings have been developed. At present, this concept has been widely used in the care of various wounds including surgical incisions, burns, pressure sores, infected wounds, and chronic refractory wounds. Compared with the traditional dry healing method, wet healing has the following advantages: 1. Regulating the oxygen tension of the wound surface, promoting the formation of capillaries; 2. Facilitating the dissolution of necrotic tissue and fibrin; 3. Promoting the release of various growth factors, these Growth factors play a very import...

AI Technical Summary

Problems solved by technology

Synthesizing hydrogel dressings by freeze-thaw method does not have the problem of using cross-linking agents and initiators, but the hydrogel dressings synthesized by this method are opaque, which is not conducive to wound observation and long-term storage, and has thermal reversibility. It is easy to deform when the temperature is high, making it difficult to transport and store, and the process of freezing and thawing will easily cause the water in the hydrogel dressing to overflow, resulting in a greatly reduced water retention capacity and a reduced ability to absorb wound exudate, thus affecting the wound. Nursing effect, not easy to adhere to the skin

The radiation method is usually used to prepare medical hydrogels, but the mechanical strength of the hydrogels prepared by the radiation method is low, especially when a single raw material is used for irradiation, the resulting gel is relatively brittle