Probiotic tablet and preparation method thereof

A probiotic tablet and tablet compression technology, which is applied in pill delivery, pharmaceutical formula, medical raw materials derived from bacteria, etc., can solve problems such as the inability of direct granulation of probiotic powder, poor fluidity of direct compression of powder, and low survival rate of viable bacteria, etc. problem, to achieve the effect of low cost, good reproducibility, and high survival rate of live bacteria

Active Publication Date: 2012-04-18
内蒙古双奇药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Another object of the present invention is to provide a dry granulation technology, which solves the problems of poor fluidity, poor compressibility, and low survival rate of live bacteria in direct powder compression, and the problem that probiotic powder cannot be directly granulated. It has the advantages of strong practicability, stable process technology, low cost, and large-scale production.

Method used

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  • Probiotic tablet and preparation method thereof
  • Probiotic tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Using dry granulation technology and tabletting technology, granules are prepared from auxiliary materials such as glucose, lactose, microcrystalline cellulose, and skimmed milk powder, and then mixed with active ingredients probiotic powder and magnesium stearate for tabletting, and finally probiotics are obtained tablet.

[0021] Its production method comprises the following steps:

[0022] (1) Preparation of pharmaceutical excipients: prepared in parts by weight, including 20 parts of glucose, 40 parts of lactose, 10 parts of microcrystalline cellulose, 10 parts of skimmed milk powder, 5 parts of sodium carboxymethyl starch, 1 part of sucrose, and 1 part of citric acid , 0.01 part of magnesium stearate;

[0023] (2) Dry granulation: After mixing the pharmaceutical excipients, add them to a dry granulator for granulation, and collect granules of 10-60 mesh for raw material mixing;

[0024] (3) Mixing of raw materials: the prepared granules and probiotic powder are m...

Embodiment 2

[0027] Using dry granulation technology and tabletting technology, granules are prepared from auxiliary materials such as glucose, lactose, microcrystalline cellulose, and skimmed milk powder, and then mixed with active ingredients probiotic powder and magnesium stearate for tabletting, and finally probiotics are obtained tablet.

[0028] Its production method comprises the following steps:

[0029] (1) Preparation of pharmaceutical excipients: prepared in parts by weight, including 40 parts of glucose, 20 parts of lactose, 30 parts of microcrystalline cellulose, 30 parts of skimmed milk powder, 15 parts of sodium carboxymethyl starch, 10 parts of sucrose, and 10 parts of citric acid , 1 part of magnesium stearate;

[0030] (2) Dry granulation: After mixing the pharmaceutical excipients, add them to a dry granulator for granulation, and collect 60-120 mesh granules for raw material mixing;

[0031] (3) Mixing of raw materials: the prepared granules and probiotic powder are m...

Embodiment 3

[0034] Using dry granulation technology and tabletting technology, granules are prepared from auxiliary materials such as glucose, lactose, microcrystalline cellulose, and skimmed milk powder, and then mixed with active ingredients probiotic powder and magnesium stearate for tabletting, and finally probiotics are obtained tablet.

[0035] Its production method comprises the following steps:

[0036] (1) Preparation of pharmaceutical excipients: prepared in parts by weight, including 25 parts of glucose, 25 parts of lactose, 20 parts of microcrystalline cellulose, 20 parts of skimmed milk powder, 10 parts of sodium carboxymethyl starch, 5 parts of sucrose, and 5 parts of citric acid , 0.5 parts of magnesium stearate;

[0037] (2) Dry granulation: After mixing the pharmaceutical excipients, add them to a dry granulator for granulation, and collect 10-30 mesh granules for raw material mixing;

[0038] (3) Mixing of raw materials: the prepared granules and probiotic powder are m...

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Abstract

The invention discloses a manufacturing method and a probiotic tablet with high living bacterium survival rate manufactured by applying the method; the manufacturing method is as follows: applying a dry method pelleting technique and a tabletting technique and taking auxiliary materials such as glucose, lactin, microcrystalline cellulose and the like as raw material to prepare particles, and thenblending active ingredient probiotic powder and magnesium stearate to carry out tabletting, and finally obtaining the probiotic tablet. The invention has the advantages that the probiotic tablet is convenient to take and absorb and has obvious treatment effect owing to the high probiotic survival rate; the dry method pelleting technology provided by the invention has the advantages of low cost, fast discharging speed, stable technological conditions, good recurrence and high probiotic survival rate and is suitable for large-scale production.

Description

Technical field: [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a probiotic tablet prepared by dry granulation technology and a preparation method thereof. Background technique: [0002] Probiotic tablet is a microecological preparation that can regulate the balance of human intestinal flora. The probiotics living in the human intestinal tract can inhibit the growth of harmful microorganisms and pathogenic microorganisms such as salmonella in food. Probiotics pass through the intestinal tract. It produces acid, bacteriocin and competes for the receptors of the intestinal mucosa and improves the body's immunity to exert its effect. Probiotic tablets can be used to treat diarrhea, constipation and other symptoms, and also have health care effects. The active active ingredient is live probiotic powder, and the common probiotics include Bifidobacterium longum, Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacill...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K35/74A61K47/38A61P1/00A61K35/741
Inventor 黄少磊夏少明刘彦民董至恒刘斌马征途丁丽李林泉刘云辉白志荣
Owner 内蒙古双奇药业股份有限公司
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