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Preparation method of guava leaf extract and traditional Chinese medicine preparation thereof

A guava leaf and extract technology, applied in the field of preparation of guava leaf extract, can solve the problems of unacceptable industrial production, difficult control of production links, large ethanol consumption, etc., and achieve simple operation equipment and process flow, The effect of direct curative effect and simple production process

Active Publication Date: 2011-11-02
蚌埠丰原涂山制药有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the yield of total flavonoids extracted by the water extraction method is higher, while the flavonoids and phenols (the main components of the curative effect) are relatively low; by the alcohol extraction method, the yield of flavonoids and phenols is higher, but the ethanol consumption Large, low recovery rate, so the cost is high, and industrial production is not advisable; enzymatic extraction requires the enzyme to have extremely high activity, high specificity and mild reaction conditions, and the enzymatic method is limited by the type of enzyme, dosage, enzymatic hydrolysis Influenced by various factors such as time, temperature, pH, material fineness, stirring, etc., the production process is difficult to control, so it will ultimately affect the extraction yield

Method used

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  • Preparation method of guava leaf extract and traditional Chinese medicine preparation thereof
  • Preparation method of guava leaf extract and traditional Chinese medicine preparation thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 (preliminary test)

[0037] Grind 64kg of guava leaf medicinal material, pack part of the fine powder into bags, put into a decoction tank, add 640kg of drinking water, heat to boil, keep warm and soak until the next day, heat and decoct for 3 hours, add 600kg of water for the second decoction, and decoct After 3 hours, the decoction liquid was combined with three effects and concentrated to a density of 1.15g / mL and a weight of about 15kg. Then, 4 times the amount of 95% ethanol was added to about 60kg. The ethanol concentration at this time was measured to be 75%. Clear liquid, the concentration of ethanol at this time is about 88%, concentrated in vacuum to a density of 1.30g / mL, and 2.5kg of extract is collected, and the precipitate is alcohol-precipitated once according to the above method, and a total of about 1.5kg of extract is collected, dried , vacuum-drying the above two received extracts at 80°C for about 4 hours (part of the baking tray is cove...

Embodiment 2

[0040] Embodiment 2 (on the basis of preliminary test, alcohol precipitation process is improved)

[0041]Put 60.0kg of guava leaves into the traditional Chinese medicine extraction tank, add about 600kg of water, turn on the steam valve and heat to 80°C, soak for 14 hours. Heat and decoct until boiling and keep the boiling time for 3 hours, pour the decoction liquid into the three-effect concentration tank; add about 600kg of water to the second slag, decoct until boiling and keep the boiling time for 3 hours, filter the feed liquid to the concentration tank to concentrate When the density is 1.18g / mL, the ointment is collected, and the weight is about 40kg.

[0042] One-time alcohol precipitation: add 40kg extract into the alcohol precipitation tank, heat and stir, add 82kg of 95% ethanol at the same time, continue stirring, close the steam valve, and open the jacket cooling water, continue stirring for about 20 minutes, measure the alcohol precipitation supernatant Concent...

Embodiment 3

[0047] Embodiment 3 (scale-up test, further confirms the feasibility of technique)

[0048] 1. Put 200kg of guava leaves into the extraction tank, add 2 tons of water, heat to 80°C and soak for 14 hours, decoct for 3 hours, filter out the decoction to the concentration tank, add 2 tons of water to the second residue and decoct for 3 hours, three Efficiently concentrate until the density is 1.18g / mL to collect the extract, and the weight of the extract is 105kg.

[0049] 2. Alcohol precipitation process

[0050] (1) Primary alcohol precipitation: first add about 50kg of 92% ethanol to the alcohol precipitation tank, then add the three-effect extract into the alcohol precipitation tank at one time, add ethanol while stirring, pass cooling water, and add 92% in total About 210kg of ethanol, after adding, continue to stir, vacuum backflush, measure the ethanol concentration of the ethanol sink solution to be about 58%, let it stand for 40 hours, pump the supernatant, and measure ...

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Abstract

The invention relates to a preparation method of guava leaf extract and a traditional Chinese medicine preparation thereof. The invention adopts the traditional technique 'water-extracting alcohol-sedimenting method' of the traditional Chinese medicine, optimizes the processing technique and establishes a preparation method of the guava leaf extract. The method has simple extraction technique, can extract the effective components in the guava leaf with high yield, therefore, the traditional Chinese medicine preparation product obtained by using the method has high drug effect and lower price.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of guava leaf extract and a traditional Chinese medicine preparation thereof. Background technique [0002] Guava (Psidium guajava) is a plant of the genus Guava in the family Myrtaceae, which originated in tropical America and was planted in the temperate and subtropical regions of my country more than 200 years ago. Guava has attracted the attention of scientists due to its strong antioxidant capacity in its leaves. Guava leaves have the functions of softening blood vessels, lowering blood sugar, blood lipids and cholesterol; having the effect of resisting hypoxia and quickly eliminating fatigue; at the same time helping to delay the peroxidation process of organisms, and preventing cancer, heart disease and other cardiovascular and cerebrovascular diseases. In guava leaves, it has been found to contain a variety of impo...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61P3/10A61K127/00
Inventor 朱学娟汪洪湖
Owner 蚌埠丰原涂山制药有限公司
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