Compound Chinese medicinal preparation for treating lung cancer and preparation method thereof

A compound traditional Chinese medicine and preparation technology, applied in the field of medicine, can solve the problems of aggravating the economic and psychological burden of patients, affecting the overall curative effect of traditional Chinese medicine prescriptions, and low content of active ingredients, so as to inhibit the metastasis and spread of cancer cells, inhibit metastasis and spread, good curative effect

Inactive Publication Date: 2010-05-19
常熟雷允上制药有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] At present, most of the drugs widely used in the treatment of lung cancer in the market are chemical drugs and biological products, especially targeted agents and antimetabolites. However, these first-line tumor drugs are not only expensive, but also have different degrees of adverse reactions: such as Docetaxel has myelosuppressive side effects, recombinant human endostatin has obvious cardiac adverse reactions, erlotinib has an induction rate of interstitial lung disease (ILD) as high as 0.8%, and chemical anticancer drugs are still widely available Adverse reactions of different degrees of gastrointestinal tract, hair loss and local irritation
In order to reduce adverse reactions, follow-up treatment, continuous reexamination and strengthened monitoring are required when using combined treatment, which not only

Method used

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  • Compound Chinese medicinal preparation for treating lung cancer and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0032] 1. The raw material composition of the compound Chinese medicine preparation: Vitex 300g, Astragalus 320g, Brucea javanica 200g, Corrugated seed 195g, Tinglizi 200g, licorice 200g.

[0033] 2, the preparation method of compound Chinese medicine preparation:

[0034] (1) Take 300g of Vitex Vitex, grind it into a coarse powder, add 60% ethanol with 5 times the concentration of Vitex Vitex as a desorbent, heat to 22°C, soak for 30min; add 30% ethanol with 8 times the concentration of Vitex Vitex to extract 3 Once, each time for 1.5 hours, the extracts were combined and concentrated, and the concentrated solution was applied to D101 macroporous resin, eluted with 80% ethanol, the ethanol was recovered under reduced pressure, and spray-dried for later use;

[0035] (2) Get Radix Astragali 320g, beat into coarse powder, add the concentration 5% ethanol solution of Radix Astragali medicinal material 10 times of amount, ultrasonic extraction twice, extract 1.5 hours each time, ...

Embodiment 2

[0041] 1. The raw material composition of the compound Chinese medicine preparation: Vitex 330g, Astragalus 300g, Brucea javanica 180g, Corrugated seed 170g, Tinglizi 160g, licorice 200g.

[0042] 2, the preparation method of compound Chinese medicine preparation:

[0043] (1) Take Vitex Vitex 330g, beat it into coarse powder, add Vitex Vitex 8 times the concentration of 70% ethanol as a desorbent, heat to 30°C, soak for 40min; add Vitex Vitex 6 times the concentration of 30% ethanol for reflux extraction Once, each time for 1.5 hours, the extracts were combined and concentrated, and the concentrated solution was applied to D101 macroporous resin, eluted with 85% ethanol, the ethanol was recovered under reduced pressure, and spray-dried for later use;

[0044] (2) Get Radix Astragali 300g, beat into coarse powder, add the concentration 5% ethanol solution of Radix Astragali medicinal material 8 times of amount, ultrasonic extraction twice, extract 1.5 hours each time, merge ex...

Embodiment 3

[0050] 1. The raw material composition of the compound Chinese medicine preparation: Vitex 360g, Astragalus 285g, Brucea javanica 267g, Corrugated seed 186g, Tinglizi 186g, licorice 186g.

[0051] 2, the preparation method of compound Chinese medicine preparation:

[0052] (1) Take Vitex Vitex 360g, grind it into coarse powder, add Vitex Vitex 10 times the concentration of 60% ethanol as a desorbent, heat to 45°C, and soak for 30 minutes; add Vitex Vitex 8 times the concentration of 50% ethanol for reflux extraction 3 Once, each time for 1.5 hours, the extracts were combined and concentrated, and the concentrated solution was applied to D101 macroporous resin, eluted with 80% ethanol, the ethanol was recovered under reduced pressure, and spray-dried for later use;

[0053] (2) Get Radix Astragali 285g, beat into coarse powder, add the concentration 5% ethanol solution of 6 times of amount of Radix Astragali medicinal material, ultrasonic extraction twice, extract 1.5 hours eac...

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Abstract

The invention discloses a compound Chinese medicinal preparation for treating lung cancer, a preparation method thereof and application thereof. The compound Chinese medicinal preparation is prepared from the following raw material medicaments in percentage by weight: 20 to 40 percent of hemp-leaved vitex, 20 to 40 percent of astragalus, 10 to 20 percent of java brucea fruit, 10 to 20 percent of ark shell, 10 to 20 percent of descurainia sophia (L.) webb ex prantl and 8 to 20 percent of liquorice root. Pharmacological tests and clinical experiments show that the compound Chinese medicinal preparation provided by the invention has good effects of relieving pain and strengthening the immunity, can effectively resist the non-small-cell lung cancer, inhibit the metastasis and diffusion of cancer cells, prevent the growth of tumors and reduce the toxic and side effect of chemotherapy on human bodies, and is low in adverse reaction. The preparation method for the compound Chinese medicinal preparation provided by the invention combines the traditional technique and the modern technique, adopts the most appropriate and effective extraction and preparation technology for different raw medicament materials, and has the advantages of strong operability, low production cost, and suitability for industrial production.

Description

technical field [0001] The invention relates to a medicine, in particular to a compound traditional Chinese medicine preparation, a preparation method thereof and an application of the compound traditional Chinese medicine preparation. Background technique [0002] Lung cancer (Carcinoma of the lung) refers to cancer that originates in the bronchus and lung, and has become one of the most common malignant tumors in humans. Its pathogenesis is the same as that of other systemic tumors in the whole body, and it is still unclear. It has been affirmed that smoking is one of the main causes of lung cancer, and occupational factors, air pollution and ionizing radiation may also be the cause of lung cancer. In cities, the incidence rate of lung cancer is 49.19 per 100,000 people, ranking first in urban cancer incidence; in rural areas, the incidence rate of lung cancer is 33.52 per 100,000 people, ranking fourth in urban cancer incidence. [0003] Lung cancer is divided into smal...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/16A61K9/20A61K9/48A61P11/00A61P35/00A61K35/56A61K35/618
Inventor 曾陵顾治平王恒斌陈力建
Owner 常熟雷允上制药有限公司
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