Bone tissue engineering bracket material and preparation method and application thereof

A technology for bone tissue engineering and scaffold materials, which is applied in scaffolds, medical science, prostheses, etc., and can solve the problems of low porosity and poor pore connectivity of scaffolds.

Inactive Publication Date: 2010-06-09
SHANGHAI TISSUE ENG LIFE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to prepare porous scaffolds suitable for bone tissue engineering applications, scholars at home and abroad have used various methods such as organic foam imp

Method used

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  • Bone tissue engineering bracket material and preparation method and application thereof
  • Bone tissue engineering bracket material and preparation method and application thereof
  • Bone tissue engineering bracket material and preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0037] The method for preparing bone tissue engineering scaffold material provided by the present invention includes the steps of: mixing calcium phosphate dual-phase powder with a medically acceptable binder, then mixing with paraffin microspheres and calcining to obtain bone tissue engineering provided by the present invention Scaffolds.

[0038] In the preparation method provided by the present invention, the porosity of the scaffold material obtained can be adjusted according to the different mass ratios of the added paraffin microspheres and calcium phosphate dual-phase powder, and the paraffin microspheres and calcium phosphate dual-phase powder The mass ratio of phase powder is 5:1-9:1; preferably 5.5:1-7.5:1. As the amount of paraffin microspheres increases, the porosity of the porous scaffold material increases accordingly. If the amount of paraffin microspheres added is too low, the scaffold material obtained after calcination has almost no through holes; and after ...

Embodiment 1

[0058] Scaffold material for bone tissue engineering I

[0059] Mix 1g of calcium phosphate biphasic powder (the molar ratio of HAP and TCP is 2:1) with 0.3g of silica sol (concentration: 15w / v%, purchased from Qingdao Ocean Chemical Co., Ltd.), and then add a particle size of 300- 6 g of 500 μm paraffin microspheres (paraffin was purchased from Shanghai Huayong Paraffin Co., Ltd., the microspheres were self-made), mixed evenly, and then statically pressed to obtain a ceramic body. Dry at room temperature for 2 days, dry in an oven at 37°C for 4 days, and place in a muffle furnace for calcination. Raise the temperature up to 200°C at a rate of 1°C / min, keep it warm for 1 hour, then raise the temperature up to 1100°C at a rate of 2°C / min and keep it warm for 3 hours, then cool down to room temperature with the furnace to obtain bone tissue engineering scaffold material I. Gross and scanning electron microscope (SEM) images of the ceramics are shown in figure 1 middle.

[006...

Embodiment 2

[0062] Scaffold Materials for Bone Tissue Engineering II

[0063] Mix 1g of calcium phosphate powder (the molar ratio of HAP and TCP is 1:3) with 0.6g of silica sol (concentration: 20w / v%, purchased from Qingdao Ocean Chemical Co., Ltd.), and then add 150-300μm and 300 - 3 g of 500 μm paraffin microspheres (paraffin was purchased from Shanghai Huayong Paraffin Wax Co., Ltd., and the microspheres were self-made), mixed evenly, and then statically pressed. Dry at room temperature for 1 day, dry in an oven at 37°C for 4 days, and place in a muffle furnace for calcination. Raise the temperature to 150°C at a rate of 0.5°C / min, hold for 2 hours, then raise the rate of 2°C / min to 1050°C and hold for 3 hours, and cool to room temperature with the furnace to obtain porous biphasic calcium phosphate ceramics. Gross and SEM photographs of the ceramics are shown in figure 2 middle.

[0064] The results show that the pore diameter range of the scaffold material is 250-450 μm, the conn...

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Abstract

The invention discloses a bone tissue engineering bracket material and a preparation method and application thereof. The bracket material is prepared from calcium phosphate diphase power and has a porous structure with the pore diameter of 100-600 micrometers, the through pore diameter of 45-130 micometers and the porosity of 45-93 percent. The calcium phosphate diphase power contains hydroxyapatite and tricalcium phosphate in the mol ratio of 0-1.

Description

technical field [0001] The invention relates to the field of biomaterials and tissue engineering, in particular to a bone tissue engineering scaffold material and its preparation method and application. Background technique [0002] In the field of bone tissue engineering, hydroxyapatite (HAP) and tricalcium phosphate (TCP) are two widely used scaffold materials. They all have good biocompatibility, and when they are implanted into body tissues, they do not produce local and systemic toxic reactions, nor local inflammation and rejection reactions. Moreover, the implant can be combined with the bone bed, and fibrous tissue is not formed between the two to play its role of scaffolding and bone guidance. Tricalcium phosphate is implanted into bone tissue or subcutaneously and can be degraded and absorbed; hydroxyapatite has good osteoinductivity, and biphasic tricalcium phosphate ceramics can provide a more ideal growth environment for bone marrow mesenchymal stem cells. [0...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/56A61F2/82
Inventor 赵莉曹谊林何晨光崔磊
Owner SHANGHAI TISSUE ENG LIFE SCI
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