Method for preparing shell-core micrometer/nanometer spheres capable of preventing functional materials

Abstract

The invention belongs to the technical field of inorganic nanometer materials, in particular to a method for preparing shell-core micrometer / nanometer spheres capable of preventing functional materials. The method comprises the step of coating a compact silicon dioxide shell layer on the surfaces of the traditional micrometer / nanometer spheres wrapping functional materials to seal and protect the functional materials with an anti-leakage ratio of 98 percent. The shell layer of silicon dioxide is easy to modify by introducing rich chemical functional groups and convenient to couple biomacromolecules in the field of biomedicines. The shell-core micrometer / nanometer spheres, prepared by the method, have the advantages of avoiding the damage caused by the infiltration of the environmental medium into the micrometer / nanometer spheres to the properties of the functional materials, avoiding the direct contact with the bioactive materials, introducing the rich chemical functional groups to the surfaces of the micrometer / nanometer spheres, and being conveniently crosslinked with biological proteins and nucleic acid molecules, along with smooth surfaces and little non-specific adsorption; and the preparation method has the advantages of simpleness, easy operation, strong operability, good repeatability, and low cost. The shell-core micrometer / nanometer spheres coated with silicon dioxide are stable in performance and long in holding time, and can be widely applied in biochemical analysis fields of biological marking, biological separation, cell imaging and development, biological sensors and the like.

Description

technical field

[0001] The invention belongs to the technical field of inorganic nanometer materials, and in particular relates to a method for preparing core-shell micro / nanospheres capable of preventing leakage of functional substances. Background technique

[0002] The application of functional micro / nanospheres in the field of biomedicine has attracted more and more attention. The most representative functional micro / nanospheres are magnetic micro / nanospheres and fluorescent micro / nanospheres. They are the hotspots of scholars at home and abroad. At present, there are commercially available magnetic micro / nanospheres and fluorescent micro / nanospheres. Most of its preparation methods adopt the embedding method, that is, by swelling the polymer carrier, the functional substances mixed with it (such as magnetic nanoparticles, fluorescent dye molecules, quantum dots, etc.) penetrate into the polymer matrix to achieve embedding. Combined with the role of fixed functional s...

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