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Method for detecting quality of blood-activating analgesic plaster

A quality detection method and technology of Huoxue Zhitong ointment are applied in the field of quality detection of Huoxue Zhitong ointment, which can solve the problems that the quality detection method of Huoxue Zhitong ointment cannot meet the requirements, and achieve the effects of simple and convenient method, accurate and reliable results, and quality monitoring.

Active Publication Date: 2013-03-13
ANHUI ANKE YULIANGQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, as the State Food and Drug Administration has comprehensively improved the drug standards of the three major categories of drugs including national essential drugs to ensure the safety and quality of drugs in my country, so that the drug standards have basically reached the international standard level, the above-mentioned quality detection methods for Huoxue Zhitong Ointment cannot meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 10 pieces (6.5cm×5cm) or 5 pieces (7cm×10cm) of Huoxue Zhitong ointment, add 100ml of chloroform and soak for 30 minutes, stir to remove the ointment, pour out the ointment, add 50ml of methanol, stir, and let it stand for 5 minutes. Pour out the liquid medicine, evaporate to dryness below 80°C, add 2ml of methanol to the residue, stir well, centrifuge (10000 rpm) for 2 minutes, and use the supernatant as the test solution;

[0014] Take 0.5g of Angelica as the reference medicinal material, add 20ml of absolute ethanol and reflux for 30 minutes, let it cool, filter, evaporate the filtrate to dryness, add 1ml of methanol to the residue and dissolve it as the reference medicinal material solution, and use thin-layer chromatography (Appendix VIB, Part I, Chinese Pharmacopoeia 2005 Edition) For the test, draw 10 μl of the test solution and 5 μl of the control medicinal material solution, respectively spot on the same silica gel G thin-layer plate, use cyclohexane:ethyl ...

Embodiment 2

[0016] For the preparation of test solution reference, refer to Example 1;

[0017] Take hesperidin reference substance, add methanol to make a saturated solution, as the reference substance solution. According to the test of thin-layer chromatography (Appendix VIB of Chinese Pharmacopoeia 2005 Edition), absorb 10 μl of the test solution under the item of identification (1), and 5 μl of the reference solution, and spot them on the same silica gel prepared with 0.5% sodium hydroxide solution. On G thin-layer board, use ethyl acetate:methanol:water ratio of 100:17:13 as the developer, develop to about 10cm, take it out, dry it in the air, spray with aluminum chloride test solution, and heat at 105°C After 5-10 minutes, put it under the ultraviolet lamp (365nm) to check, in the chromatogram of the test product, at the position corresponding to the chromatogram of the reference product, there will be fluorescent spots of the same color.

Embodiment 3

[0019] Take 20 pieces (6.5cm×5cm) or 10 pieces (7cm×10cm) of Huoxue Zhitong ointment, add 100ml of ether and soak for 30 minutes, stir to remove the ointment, pour out the ointment, add 50ml of ether to the residue and stir, combine the ether solution, add methanol 30ml, stir while adding, let it stand for 5 minutes, pour out the liquid medicine, steam until about 5ml is left, add 20ml of 5% sulfuric acid solution, stir well, filter, add concentrated ammonia test solution to the filtrate to make it alkaline, add 20ml of diethyl ether to shake Shake, separate the ether solution, evaporate to dryness, add 1ml of absolute ethanol to the residue to dissolve, concentrate to 0.2ml, and use it as the test solution;

[0020] Take atropine sulfate reference substance, add absolute ethanol to make a solution containing 2mg per 1ml, as the reference substance solution. According to the thin-layer chromatography (Appendix VIB of "Chinese Pharmacopoeia" 2005 Edition), draw 20 μl of the tes...

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Abstract

The invention relates to the drug quality detection field, in particular to a method for detecting the quality of a blood-activating analgesic plaster, which comprises the following steps: angelica sinensis, hesperidin, atropine sulfate, chrysophanol and cortex periplocae in the blood-activating analgesic plaster are identified by a thin layer chromatography, and then component contents in the blood-activating analgesic plaster are detected by a gas chromatograph. The method for detecting the quality of the blood-activating analgesic plaster combines the thin layer chromatography and the gas chromatograph for detecting the effective components and contents of the blood-activating analgesic plaster, the detected result is accurate and reliable, the quality of the blood-activating analgesic plaster can be effectively monitored, and the method is simple and convenient and is easy to operate.

Description

technical field [0001] The invention relates to the field of drug quality detection, in particular to a quality detection method of Huoxue Zhitong ointment. Background technique [0002] Huoxue Zhitong Ointment has the functions of promoting blood circulation and relieving pain, relaxing tendons and dredging collaterals, etc. It can be used for the treatment of muscle and bone pain, muscle paralysis, phlegm nucleus flow, and joint pain. The current quality standard of Huoxuezhitong ointment is implemented according to the second volume of the drug standard of the Ministry of Health of the People's Republic of China. It has strict requirements on the properties, paste content, heat resistance, appearance and specifications of Huoxuezhitong ointment. (1) The properties of Huoxuezhitong ointment are light brown to orange flake rubber paste with fragrant gas; Weigh it, put it in a glass container with a cover, add an appropriate amount of organic solvent (such as chloroform, et...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P29/00G01N30/90A61K31/045A61K31/46
Inventor 谢红星潘泽华田湘玲
Owner ANHUI ANKE YULIANGQING PHARMA
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