Compound matrine and diversine nano-emulsion preparation and preparation method thereof

Abstract

The invention discloses a compound matrine and diversine nano-emulsion preparation which comprises 0.10-10.00 percent of matrine, 0.10-4.00 percent of diversine, 20.00-38.73 percent of surfactant, 1.64-8.28 percent of oil phase, 0.10-10.00 percent of cosurfactant, 1.00-8.00 percent of azone and 44.00-77.06 percent of distilled water. The compound matrine and diversine nano-emulsion preparation isa transparent oil-in-water nano-emulsion, has the liquid drop grain diameter of 1-100nm, has good stability, improves the solubility and the stability of a medicament, has good skin affinity, enablesthe medicament to faster enter systemic circulation through the skin, avoids the hepatic first pass effect and the gastrointestinal side reaction of the medicament, everlastingly provides the steady flow of the medicament, improves the bioavailability of the medicament, enhances the curative effect of the medicament, is easy to prepare and store and has low production cost and broad market prospects in the medical field.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a new dosage form of traditional Chinese medicine extract matrine and sinomenine, in particular to a compound matrine and sinomenine nanoemulsion preparation for transdermal administration and a preparation method thereof. Background technique [0002] Drug transdermal drug delivery system refers to a new preparation that is administered on the skin surface, and the drug passes through each layer of the skin at a constant speed (or close to a constant speed), enters the systemic circulation, and produces systemic or local therapeutic effects. Compared with traditional drug delivery methods, transdermal preparations have the following advantages: they can produce persistent, constant and controllable blood drug concentration, thereby reducing adverse reactions; avoiding the first-pass effect of the liver and improving the bioavailability of drugs; The pain of injection medicine; patien...

AI Technical Summary

Problems solved by technology

However, the oral bioavailability of sinomenine is low, and the half-life is short (about 5-6h). It needs to be administered orally for a long time, and there are side effects such as rash and gastrointestinal tract after oral administration.

Injections are easy to cause pain and are not convenient for patients to use well

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