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Pharmaceutical composition for improving immunity

A technology that enhances immunity and composition, applied in the field of medicine, can solve problems such as safety hazards and adverse reactions, and achieve the effects of improving body resistance, high bioavailability, and high development and utilization value

Inactive Publication Date: 2010-07-14
KUNMING PHARMA GRP JINTAIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the defects of potential safety hazards or adverse reactions in immunity-enhancing drugs in the prior art, and provides a new pharmaceutical composition for enhancing immunity, which can promote blood circulation and remove blood stasis by synergistically exerting the pharmacological effects of two traditional Chinese medicine extracts , clear the meridians, improve cerebral blood flow, improve the energy metabolism state during hypoxia, enhance immunity, and improve the body's ability to resist fatigue and anti-aging

Method used

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  • Pharmaceutical composition for improving immunity
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Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1: Preparation of Panax notoginseng saponins and star anise oil

[0033] The Panax notoginseng plant of the Araliaceae genus is crushed, extracted with ethanol, separated by macroporous adsorption resin, refined by alumina, etc., to extract the total saponins of Panax notoginseng, and oxidize the total saponins of Panax notoginseng according to the requirements of the main effect. Aluminum, silica gel, and resin are used as layer absorbents, and 0-95% ethanol, methanol, petroleum ether, ethyl acetate, and water are used as eluents to prepare ginsenosides Rg1 and Rb1 in accordance with the specified ratio of Panax notoginseng saponins to meet the preparation requirements. efficacy needs.

[0034]The specific method is as follows: take Panax notoginseng and crush it into 5-10 mesh particles, soak it in 50-85% ethanol for three to four times, combine the soaking liquid and concentrate it until it has no alcohol smell or a certain specific gravity, and pass throu...

Embodiment 2

[0035] Embodiment 2: the preparation of star anise oil that preferred relative density is 0.975-0.988

[0036] Funing County is the hometown of star anise in China, and star anise is a local characteristic biological resource. The Foreign Trade Bureau of Napo County is a large-scale purchase point for crude oil processed by Funing farmers. The purchased products are of high purity and easy to refine. Weigh the star anise oil purchased from the Napo County Foreign Trade Bureau and pour it into the fractionating pot, heat and decompress and fractionate, and when the bottom temperature of the tower is controlled at 60-70°C, collect the fractionated head oil, the amount is 8-8% of the crude oil added. 9% or so. Continue heating fractionation, when the temperature at the top of the tower is 120-125°C, collect the fractionated essential oil, let the essential oil stand for more than 24 hours, and drain the water layer to obtain star anise oil with a relative density of 0.975-0.988 a...

Embodiment 3

[0037] Embodiment 3: prepare the soft capsule of pharmaceutical composition of the present invention

[0038] The formula of encapsulation liquid: star anise oil 0.02-0.6g / grain, notoginseng total saponins 0.025-0.1g / grain; vegetable oil 0-2g / grain.

[0039] The star anise oil prepared in Example 2 is the star anise oil that meets the current Chinese Pharmacopoeia standard, or directly purchase the star anise oil produced by Baoji Jinsen Pharmaceutical Co., Ltd. or Guangxi Wanshan Spice Co., Ltd.

[0040] The total Panax notoginsenosides prepared in Example 1 contain 5-40% of ginsenoside diol Rb1, 20-75% of ginsenoside triol Rg1, and 15%-8% of Panax notoginsenosides.

[0041] The capsule shell is made of 0.95-1.05 parts by weight of gelatin, 0.2-0.3 parts by weight of gum arabic, 0.7-0.8 parts by weight of glycerin, 0.1-0.2 parts by weight of syrup and a small amount of pigment.

[0042] The preparation method of the soft capsule of the present invention is as follows: the en...

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Abstract

The invention relates to the medical field, and discloses a pharmaceutical composition for improving immunity, comprising: 0.1-60wt percent of star anise oil and 0.5-10wt percent of panax notoginseng saponins, wherein the panax notoginseng saponins comprises the components by weight percent: 5-40 percent of ginsenoside diol Rb1, 20-75 percent of ginsenoside triol Rg1 and 5-8 percent of notoginsenoside R1. The invention also provides various formulations of the pharmaceutical composition. The mouse oxygen-poor-resistance and anti-fatigue capability experiment proves that a tested mouse taking the pharmaceutical composition survives obviously longer than that of a compared group under the oxygen-poor environment and in the experiment of swimming with a load, so that the pharmaceutical composition has remarkable enhancing oxygen-poor-resistance and anti-fatigue capability, higher development and utilization values as well as market application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition for enhancing immunity. Background technique [0002] Panax notoginseng total saponins are the main active ingredients extracted from Panax notoginseng, mainly composed of tetracyclic triterpene dammarane type protopanaxadiol group saponins and tetracyclic triterpene dammarane type protopanaxatriol group saponins. Panax notoginseng saponins have a good hemostatic effect, can significantly shorten the bleeding and coagulation time, promote the division and growth of human red blood cells, and have obvious blood enriching effects. It can also significantly increase the phagocytosis rate of macrophages, increase the ratio of lymphocytes in the blood, and has the effects of promoting blood circulation and removing blood stasis, removing blood stasis and promoting regeneration. [0003] Star anise is a Magnoliaceae plant, which is mainly used as a stomach invigora...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61K9/20A61K9/16A61K9/48A61P37/04
Inventor 李刚蒋次清李东芬梁程
Owner KUNMING PHARMA GRP JINTAIDE PHARMA
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