Porous polymer nanoparticles and preparation method thereof

A technology of porous polymers and nanoparticles, applied in the fields of alkali metal compounds, chemical instruments and methods, pharmaceutical formulations, etc., can solve the limitations of large particle size, biocompatibility and biodegradability, and it is difficult to reach the microporous scale and other issues to achieve the effect of easy large-scale industrial production

Active Publication Date: 2010-09-08
武汉华科中英纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These inorganic materials generally have defects in practical applications: 1. It is difficult to reach the micropore scale (less than 2nm) through the regulation of the pore size, and cannot load some small molecule drugs, and cannot separate smaller molecules, so the application is

Method used

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  • Porous polymer nanoparticles and preparation method thereof
  • Porous polymer nanoparticles and preparation method thereof
  • Porous polymer nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1) Add 40ml of distilled water, a mixed monomer of 3.92g of chloromethylstyrene and 0.08g of divinylbenzene, and 0.16g of dodecyl to a four-necked flask equipped with a mechanical stirrer, a reflux condenser, a thermometer and a vent tube. sodium sulfate. During the process of pre-emulsification and emulsion polymerization, nitrogen gas was continuously passed, and mechanical stirring was performed at 425 rpm. At room temperature, pre-emulsify for 0.5-2 hours, then heat up to 60-80°C, add 0.04g of potassium persulfate in 5ml of distilled aqueous solution, keep the reaction for 6-10 hours, stop the reaction, and cool down to room temperature. The emulsion obtained by the reaction was demulsified with methanol, then centrifuged, filtered, and washed with distilled water to obtain a white solid product, which was lyophilized and dried for 24 hours, and the obtained white powder was a monodisperse porous polymer nanoparticle precursor.

[0042] 2) At room temperature, add ...

Embodiment 2

[0044] 1) Add 40ml of distilled water, a mixed monomer of 3.92g of styrene and 0.08g of divinylbenzene, and 0.08g of sodium dodecylsulfonate into a four-necked flask equipped with mechanical stirring, a reflux condenser, a thermometer and a vent tube . During the process of pre-emulsification and emulsion polymerization, nitrogen gas was continuously passed, and mechanical stirring was performed at 425 rpm. At room temperature, pre-emulsify for 0.5-2 hours, then heat up to 60-80°C, add 0.04g of ammonium persulfate in 5ml of distilled aqueous solution, keep the reaction for 6-10 hours, stop the reaction, and cool down to room temperature. The emulsion obtained by the reaction was demulsified with methanol, then centrifuged, filtered, and washed with distilled water to obtain a white solid product, which was lyophilized and dried for 24 hours, and the obtained white powder was a monodisperse porous polymer nanoparticle precursor.

[0045] 2) At room temperature, add 30ml of 1,2...

Embodiment 3

[0047] 1) Add 40ml of distilled water, a mixed monomer of 3.92g of 3-vinylaniline and 0.08g of divinylbenzene, and 0.08g of dodecyl sulfonate into a four-necked flask equipped with mechanical stirring, reflux condenser, thermometer and ventilation tube. Sodium acid. During the process of pre-emulsification and emulsion polymerization, nitrogen gas was continuously passed, and mechanical stirring was performed at 425 rpm. At room temperature, pre-emulsify for 0.5-2 hours, then heat up to 60-80°C, add 0.04g of ammonium persulfate in 5ml of distilled aqueous solution, keep the reaction for 6-10 hours, stop the reaction, and cool down to room temperature. The emulsion obtained by the reaction was demulsified with methanol, then centrifuged, filtered, and washed with distilled water to obtain a white solid product, which was lyophilized and dried for 24 hours, and the obtained white powder was a monodisperse porous polymer nanoparticle precursor.

[0048] 2) At room temperature, a...

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Abstract

The invention provides porous polymer nanoparticles and a preparation method thereof. The porous polymer nanoparticles are prepared by an emulsion polymerization method, and have the adjustable porous size, the monodisperse particle size, the adjustable particles size and a high specific area. Compared with the traditional porous polymer particles, the porous polymer nanoparticles have the porous size with adjustable range of between 0.5 and 100nm, the monodisperse particle size, and the particles size with adjustable range of between 20 and 200nm, so the porous polymer nanoparticles can be used as a catalyst carrier, a separation membrane, a gas storage material, a medicament carrier of animal and plant cells, a medicament carrier of animal and plant tissues and a novel template agent of a complex structure material. The preparation method comprises the following steps of: polymerizing a styrene monomer and a divinylbenzene monomer by the emulsion polymerization method to obtain a precursor of the monodisperse porous polymer nanoparticles; and then performing ultra-crosslinking on the precursor of the monodisperse porous polymer nanoparticles by an internal crosslinking method or an external crosslinking method to obtain the monodisperse porous polymer nanoparticles.

Description

technical field [0001] The invention belongs to the technical field of new chemical materials, and relates to nanoparticles and a preparation method thereof, in particular to porous polymer nanoparticles and a preparation method thereof. Background technique [0002] Porous nanoparticles are widely used as catalyst carriers, separation membranes, gas storage materials, animal and plant cell drug carriers, animal and plant tissue drug carriers, and templates for new complex structural materials. At present, porous nanoparticles are mainly silica-based inorganic materials modified by functional groups or a small amount of other inorganic materials. These inorganic materials generally have defects in practical applications: 1. It is difficult to reach the micropore scale (less than 2nm) through the regulation of the pore size, and cannot load some small molecule drugs, and cannot separate smaller molecules, so the application is limited. Scope; 2. The application of inorganic ...

Claims

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Application Information

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IPC IPC(8): C08F212/14C08F212/36C08F2/24C08J3/24C08L25/08C08K5/06C08F212/08C08L25/18B01J32/00B01D71/28B01J20/28B01J20/26B01J20/30A61K47/32
Inventor 谭必恩李步怡
Owner 武汉华科中英纳米科技有限公司
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