Method for preparing crosslinked polymer nanometer micelle with structure simulating outer cell membranes
A technology of imitating cell outer membrane and structural polymer, applied in the field of biomedical materials, can solve the problem of not being able to completely avoid the phagocytosis of mononuclear macrophages, and achieve the effect of prolonging residence time, improving stability and avoiding phagocytosis
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Embodiment 1
[0028] Example 1: Analytical balance Weigh 1.1301g of 2-methacryloyloxyethylphosphorylcholine (MPC) and dissolve it in 45mL of isopropanol, and dissolve 1.2968g of stearyl methacrylate (SMA) in 45mL In isopropanol, micropipette 548 μL of γ-methacryloxypropyltrimethoxysilane (TSMA). The monomer solution was mixed and poured into a constant pressure dropping funnel. Weigh 0.0299 g of the initiator (AIBN) and dissolve it in 6 mL of tetrahydrofuran. Pipette 4mL of the initiator solution into the graduated cylinder and add it to the constant pressure dropping funnel and mix well. Add 10 mL of isopropanol into the three-necked reaction flask, and raise the temperature to 80° C. with nitrogen gas. After the temperature was constant, the monomer initiator mixed solution was added dropwise. After 3 to 4.5 hours of dripping, change to a sealed system. After 6 hours of reaction, the remaining 2 mL of initiator solution was added at one time, and the reaction was continued for 24 hour...
Embodiment 2
[0029] Example 2: Analytical balance Weigh 1.4354 g of 2-methacryloyloxyethyl phosphorylcholine (MPC) and dissolve it in 50 mL of isopropanol, and dissolve 0.7079 g of stearyl methacrylate (SMA) in 30 mL In isopropanol, micropipette and pipette 498 μL of γ-methacryloxypropyltrimethoxysilane (TSMA). The monomer solution was mixed and poured into a constant pressure dropping funnel. Weigh 0.0266 g of the initiator (AIBN) and dissolve it in 6 mL of tetrahydrofuran. Pipette 4mL of the initiator solution into the graduated cylinder and add it to the constant pressure dropping funnel and mix well. Add 10 mL of isopropanol into the three-necked reaction flask, and raise the temperature to 80° C. with nitrogen gas. After the temperature was constant, the monomer initiator mixed solution was added dropwise. After about 4.5 hours of dripping, it was changed to a sealed system. After 6 hours of reaction, the remaining 2 mL of initiator solution was added at one time, and the reaction...
Embodiment 3
[0031] Accurately weigh PMST73310mg, dilute to 10mL with twice distilled water, ultrasonicate for 2min, shake to dissolve the polymer completely, then shake with an oscillator at 60r / min for 12h to make the micelles evenly distributed in the solution. After centrifugation at 130 Hz for 10 min, filter the supernatant with a sand core funnel to obtain the PMST733 polymer micelle solution.
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