Compound jellyfish soluble granules for reducing blood pressure and preparation method thereof

A technology of jellyfish and granules, which is applied in the field of compound jellyfish antihypertensive granules and its preparation, can solve the problems of poor absorption and utilization, simple processing, etc., and achieve the effects of convenient mixing, good effect and reasonable process

Inactive Publication Date: 2010-10-20
SHANDONG HOMEY AQUATIC DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the shortcomings of simple processing and poor absorption and utilization effect of antihypertensive drugs in the prior art, the present invention provides a compound jellyfish antihypertensive granule and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A compound jellyfish antihypertensive granule, which contains 10% jellyfish enzymolysis extract, 30% sugar powder, 50% dextrin, and 10% extracts of traditional Chinese medicine scutellaria baicalensis, cassia seed, Zhishouwu and apocynum.

[0018] Its preparation method is as follows:

[0019] (1) Preparation of jellyfish enzymatic hydrolysis extract: select jellyfish skin as raw material, soak in water for desalination, wash and crush, then add water 5 times the weight of jellyfish skin to dilute, then add 2% jellyfish skin weight Alkaline protease, mix evenly, control the temperature at 50°C, enzymatically hydrolyze for 2 hours to obtain jellyfish enzymolysis solution; heat the jellyfish enzymolysis solution to 90-100°C and keep it for 15-20 minutes to inactivate the enzyme; then carry out Decolorization and sterilization treatment, concentration under reduced pressure at 50°C, vacuum drying at 50°C to obtain jellyfish enzymatic hydrolysis extract, crushed and passed ...

Embodiment 2

[0024] A compound jellyfish antihypertensive granule, which contains 5% jellyfish enzymolysis extract, 40% sugar powder, 40% dextrin, and 15% extracts of traditional Chinese medicine Scutellaria baicalensis, cassia seed, Zhishouwu and apocynum.

[0025] Its preparation method is as follows:

[0026] (1), preparation of jellyfish enzymolysis extract select jellyfish skin as raw material, use clear water to soak and desalt, after washing, carry out crushing treatment, then add water 3 times the weight of jellyfish skin to dilute, and then use 3% jellyfish skin weight Alkaline protease, control the temperature at 55°C, enzymatically hydrolyze for 3 hours to obtain jellyfish enzymolysis solution; heat the jellyfish enzymolysis solution to 90-100°C, keep it for 15-20 minutes to inactivate the enzyme; then decolorize and sterilize treatment, concentrated under reduced pressure at 50°C, and vacuum-dried at 50°C to obtain the jellyfish enzymatic hydrolysis extract, which was crushed a...

Embodiment 3

[0031] A compound jellyfish antihypertensive granule, which contains 20% jellyfish enzymolysis extract, 20% sugar powder, 55% dextrin, and 5% extracts of traditional Chinese medicine scutellaria baicalensis, cassia seed, Zhishouwu and apocynum.

[0032] Its preparation method is as follows:

[0033] (1), preparation of jellyfish enzymolysis extract select jellyfish skin as raw material, use clear water to soak and desalinate, wash and carry out crushing treatment, then add water 6 times the weight of jellyfish skin to dilute, and then use 1% jellyfish skin weight Alkaline protease, control the temperature at 60°C, enzymolyze for 4 hours to get jellyfish enzymolysis solution; heat the jellyfish enzymolysis solution to 90-100°C and keep it for 15-20 minutes to inactivate the enzyme; then decolorize and sterilize treatment, concentrated under reduced pressure at 50°C, and vacuum-dried at 50°C to obtain the jellyfish enzymatic hydrolysis extract, which was crushed and passed throu...

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Abstract

The invention relates to compound jellyfish soluble granules for reducing blood pressure and a preparation method thereof. The compound jellyfish soluble granules are prepared by using jellyfish skin as a raw material through the following steps: desalting, washing and grinding the jellyfish skin, adding water into the obtained product to dilute, adopting alkali protease to carry out enzymolysis to obtain enzyme solution, carrying out enzyme inactivation, decoloration and sterilization on the enzyme solution, and concentrating and drying the obtained solution to obtain an enzymatically hydrolyzed jellyfish extract; proportioning the following Chinese herbal raw materials in percentage by weight: 20 to 40 percent of baical skullcap root, 20 to 40 percent of cassia seed, 10 to 30 percent of processed tuber of multiflower knotweed and 10 to 30 percent of apocynum venetum, decocting and extracting the raw materials to obtain extracting solution, concentrating and drying the extraction solution to obtain extractum, and grinding the extractum to obtain a Chinese herbal extract; and weighing the following materials in percentage by weight: 5 to 20 percent of the enzymatically hydrolyzed jellyfish extract, 20 to 40 percent of powdered sugar, 40 to 60 percent of amylin and 5 to 20 percent of the Chinese herbal extract, adopting ethanol to wet the materials to prepare soft materials, and carrying out granulation and drying on the soft materials. The soluble granules for reducing the blood pressure has the advantages of scientific prescription, rapid adsorption and obvious effect of reducing the blood pressure. The preparation method of the compound jellyfish soluble granules has reasonable process and strong operability and is suitable for industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation with an undetermined structure of traditional herbal medicine, in particular to a compound jellyfish Jiangya granule and a preparation method thereof. Background technique [0002] Hypertension is a clinical syndrome characterized by elevated arterial systolic or diastolic blood pressure, which is often accompanied by systemic diseases of heart disease, blood vessels, brain and kidneys and other organs and structures. Complications of various diseases such as blood vessels and an important risk factor leading to stroke, promoting arteriosclerosis, and coronary heart disease. Hypertension is a chronic disease with a long incubation period. In the early stage of hypertension, there are generally no symptoms until clinical signs occur - heart attack, cerebrovascular rupture, etc. leading to death. Therefore, hypertension is called the "silent killer". This high morbidity rate, high complication rate, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/16A61P9/12A61P1/16A61K35/56A61K35/614
Inventor 刘新张绵松刘昌衡唐聚德袁文鹏孙永军孟秀梅王小军张永刚夏雪奎胡炜
Owner SHANDONG HOMEY AQUATIC DEV
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