Hydroxyapatite with hollow sphere structure and preparation method thereof

A technology of hydroxyapatite and hollow spheres, which is applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., and can solve the problem of low yield of hydroxyapatite hollow microspheres, unfavorable industrialization and application, and large pH changes of reactants and other problems, to achieve the effect of facilitating industrialization, easy control of process conditions, and uniform particle size

Inactive Publication Date: 2011-11-02
BEIJING FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires special template preparation and template removal, and the operation is relatively complicated (see J.K.Liu, Q.S.Wu, Y.P.Ding, Self-assembly and fluorescent modification of hydroxyapatite nanoribbonspherulites, Eur.J.Inorg.Chem.2005, 4145-4149)
[0010] In the above-mentioned preparation method of hydroxyapatite hollow microspheres, the yield of hydroxyapatite hollow microspheres is low, the process is complicated, and the preparation process conditions are strict. Difficult, the pH of the reactant changes greatly, and the stability of the product performance is poor, which is not conducive to industrial promotion and application

Method used

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  • Hydroxyapatite with hollow sphere structure and preparation method thereof
  • Hydroxyapatite with hollow sphere structure and preparation method thereof
  • Hydroxyapatite with hollow sphere structure and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. At room temperature, add 0.110g CaCl 2 , 0.282g potassium sodium tartrate (C 4 h 4 o 6 KNa·4H 2 O) and 0.094g NaH 2 PO 4 2H 2 O was added to 4 mL of distilled water, then 11 mL of N,N-dimethylformamide was added and stirred to obtain a uniformly dispersed suspension.

[0045] 2. Transfer all the suspension into a 20mL autoclave and seal it. Put the sealed autoclave into an oven, heat it to 200°C, and keep it warm at this temperature for 24 hours.

[0046] 3. After the autoclave was naturally cooled to room temperature, the product was taken out, and the product was separated by centrifugation. The obtained precipitate was washed twice with absolute ethanol and distilled water, and then vacuum-dried at 60°C. The degree of vacuum is -0.08MPa, and the hydroxyapatite with hollow sphere structure of the present invention is prepared.

[0047] The morphology of the prepared hollow sphere-structured hydroxyapatite was detected by scanning electron microscopy, and t...

Embodiment 2

[0054] Except that the reactant is 0.176g C 4 h 6 o 4 Ca·H 2 O, 0.141g potassium sodium tartrate (C 4 h 4 o 6 KNa·4H 2 O) and 0.054g KH 2 PO 4 5ml of distilled water and 10ml of N,N-dimethylformamide were used for the reaction; the reaction temperature was 150°C and the reaction time was 48h, and the rest were the same as in Example 1.

[0055] The morphology of the prepared hollow sphere-structured hydroxyapatite was detected by scanning electron microscopy, and the detection results are shown in Table 1.

[0056] The specific surface (Brunauer-Emmett-Teller, BET) of the prepared hydroxyapatite hollow spheres was tested with a specific surface tester (JW-04, China), and the test results are shown in Table 1.

[0057] The X-ray diffraction spectrum of the prepared hydroxyapatite hollow spheres is completely consistent with the standard JCPDS card (No.84-1998).

Embodiment 3

[0059] Except that the reactant is 0.236g Ca(NO 3 ) 2 4H 2 O, 0.423g potassium sodium tartrate (C 4 h 4 o 6 KNa·4H 2 O) and 0.183g K2 HPO 4 ·3H 2 O; 6ml of distilled water for reaction, 9ml of N,N-dimethylformamide; the reaction temperature is 120°C, and the reaction time is 72h, and the rest are the same as in Example 1.

[0060] The morphology of the prepared hollow sphere-structured hydroxyapatite was detected by scanning electron microscopy, and the detection results are shown in Table 1.

[0061] The specific surface (Brunauer-Emmett-Teller, BET) of the prepared hydroxyapatite hollow spheres was tested with a specific surface tester (JW-04, China), and the test results are shown in Table 1.

[0062] The X-ray diffraction spectrum of the prepared hydroxyapatite hollow spheres is completely consistent with the standard JCPDS card (No.84-1998).

[0063] Table 1 Performance test results of hydroxyapatite hollow spheres

[0064] Hollow sphere particle size...

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Abstract

The invention provides hydroxyapatite with a hollow sphere structure and a preparation method thereof. In the method, water-soluble calcium salt, acidic phosphate and sodium potassium tartrate (a structure setting agent) which serve as raw materials are subjected to solvothermal reaction to form the hydroxyapatite. The hydroxyapatite with the hollow sphere structure prepared by the method has theadvantages of uniform particle size, single shape, high dispersibility, large specific surface area, and wide application prospect in medicament release property and the field of biomedicine; and thepreparation method has the advantages of low-cost raw materials, simple process, convenient operation, easy control of process conditions, capability of reducing the cost and greatly simplifying the production process, no need of complex and expensive equipment, and contribution to industrial popularization. The method for synthesizing hydroxyapatite hollow spheres with a multilevel structure is firstly reported.

Description

technical field [0001] The invention relates to a phosphate and a preparation method thereof, in particular to a calcium phosphate and a preparation method thereof. Background technique [0002] Nanotechnology, information technology and biotechnology have become the three pillars of social development in the 21st century, and they are the strategic commanding heights that the world's major powers compete for. The combination of nanotechnology and biotechnology, especially with biomedical materials, gave birth to nano biomedical materials. Biomedical materials are materials used for medical purposes to diagnose, treat, repair or replace human tissues and organs or enhance their functions. Biomaterials are the basis for the study of artificial organs and medical devices, and have become an important branch of materials science. Especially with the rapid development and major breakthroughs of biotechnology, biomaterials have become a hot spot for research and development by s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
Inventor 马明国李建章
Owner BEIJING FORESTRY UNIVERSITY
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