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Method for preparing taurine particles

A technology for taurine and taurine production, which is applied in the direction of anhydride/acid/halide active ingredients, bulk transportation, metabolic diseases, etc. It can solve problems such as taurine agglomeration, and achieve simple equipment and particle size Uniform, produces tight results

Active Publication Date: 2011-10-19
HUBEI GRAND LIFE SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the problem of taurine agglomeration, and provide a method for preparing granular taurine, so that the obtained taurine particles are mainly spherical particles of 40 to 80 meshes, and the obtained taurine has good fluidity and is not easy to agglomerate , easy to transport and store, and the production process is simple, suitable for large-scale industrial production, and more in line with the current requirements of energy saving, emission reduction, low-carbon environmental protection

Method used

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  • Method for preparing taurine particles
  • Method for preparing taurine particles
  • Method for preparing taurine particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 200g of taurine and add it to 800mL of purified water, then start the mixer, beat quickly until it becomes a paste, measure the viscosity within 300-400Pa·s, stop beating, and set aside.

[0032] Put 7 kg of powdered taurine in a wet mixing granulator and stir for 70-90 seconds, then slowly pour the slurry into the stirring taurine powder, when the current value rises from 1.72 amps to about 1.88 amps Stop granulation, take out the obtained taurine granules and pass through a 14-mesh sieve with a multifunctional pharmaceutical testing machine, and dry the sieved granules in an oven at a temperature of 70°C, and take out the taurine when the temperature drops to room temperature. Sour granule, the dried taurine granule that is made crosses 16 mesh sieves with the multifunctional pharmaceutical testing machine, and gained taurine particle size distribution is as follows (get 200g sieving):

[0033] Mesh

Embodiment 2

[0035] Take 250g of taurine and add it to 750mL of purified water, then start the mixer, beat quickly until it becomes a paste, measure the viscosity within 300-400Pa·s, stop beating, and set aside.

[0036] Put 6 kg of powdered taurine in a wet mixing granulator and stir for 70-90 seconds, then slowly pour the suspension into the stirring taurine powder, when the current value rises from 1.72 amps to 1.88 amps Stop granulation at about 10 minutes, take out the obtained taurine granules and pass through a 14-mesh sieve with a multifunctional pharmaceutical testing machine. Sulfonic acid granule, the dry taurine granule that makes is crossed 16 mesh sieves with multi-function pharmaceutical testing machine, gained taurine particle size distribution is as follows table (get 200g sieving):

[0037] Mesh

Embodiment 3

[0039] Take 300g of taurine and add it to 700mL of purified water, then start the mixer, beat quickly until it becomes a paste, stop beating when the measured viscosity is 300-400Pa·s, and set aside.

[0040] Get 5 kilograms of powdered taurine and dissolve in 300 mL of purified water to make an aqueous suspension containing 70% taurine solids for subsequent use. 3500g of taurine to be granulated is placed in a wet mixing granulator and stirred for 70-90 seconds, then slowly pour the suspension into the stirred taurine powder, when the current value rises from 1.72 amps to 1.88 Stop granulation when the temperature is about 10 minutes, take out the prepared taurine granules and pass through a 14-mesh sieve with a multifunctional pharmaceutical testing machine, and dry the granules after sieving in an oven at a temperature of 70°C, and take them out when the temperature drops to room temperature Taurine granule, the dry taurine granule that is made crosses 16 mesh sieves with m...

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Abstract

The invention relates to a method for preparing medicinal particles by using a wet-method mixer granulator, in particular to a method for preparing taurine particles by using the wet-method mixer granulator. The method comprises: adding taurine in an amount which is 20 to 30 percent (w / w) based on the total weight of pure water and pulping quickly to obtain paste, and using the pulp with a viscosity of 300 to 400Pa.s as a binding agent in the preparation of the taurine particles by using the wet-method mixer granulator. The taurine particles are uniform in size, compact and smooth and are mainly 40 to 80 mesh spherical particles which account for 85 percent of the total particles. Compared with a method for preparing the taurine particles by spray drying, the method has the advantages that: the production process is simple; the energy consumption is low; and the obtained taurine particles are mainly 40 to 80 mesh spherical particles with high flowability.

Description

technical field [0001] The invention relates to a method for preparing drug granules with a wet mixing granulator, in particular to a method for preparing taurine granules with a wet mixing granulator. Background technique [0002] Taurine (Rine) is a sulfur-containing β-amino acid with a simple structure in animals. Its chemical name is 2-aminoethanesulfonic acid and its structural formula is H. 2 N-CH 2 -CH 2 -SO 3 H, odorless and slightly acidic, its dilute solution is neutral. Taurine has high chemical stability and low metabolic activity. It is widely found in the organs of humans and mammals. It is one of the most important amino acids. It has special pharmacological and physiological functions, such as anti-inflammatory, analgesic and antipyretic. , lower blood sugar, maintain normal visual function, regulate nerve conduction, regulate lipid digestion and absorption, and participate in endocrine activities, increase cardiac contractility, and improve immunity. It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/185A61P29/00A61P3/10A61P27/02A61P25/00A61P3/00A61P9/04A61P37/04
Inventor 杨若冯小路黄璐付欢
Owner HUBEI GRAND LIFE SCI & TECH CO LTD