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Orthopedic implant with nano blind hole structure on surface and application thereof

An orthopaedic and plant technology, applied in the field of medical materials, to achieve the effect of improving osseointegration and antibacterial properties

Inactive Publication Date: 2011-01-05
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the effects of nano-blind holes on cell adhesion, proliferation, differentiation, bacterial adhesion, proliferation, and biofilm formation.

Method used

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  • Orthopedic implant with nano blind hole structure on surface and application thereof
  • Orthopedic implant with nano blind hole structure on surface and application thereof
  • Orthopedic implant with nano blind hole structure on surface and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] 1. Materials and methods

[0023] (1) Experimental materials and instruments

[0024] Materials: medical titanium sheet (diameter 5mm, thickness 1mm, Shanghai Puwei Medical Instrument Factory), DAPI (4,6-diamidino-2-phenylindole), alkaline phosphatase qualitative staining box (Shanghai Compal Medical Reagent Research Co., Ltd.), Tetracycline Powder (Huamei Bioengineering Company), DMEM Medium (GIBCO, USA), Trypsin (SIGMA, USA), Fetal Bovine Serum (HYCLON, USA), Soybean Tryptone Medium (Trypticase Soy Broth , TSB, British OXOID company), other reagents are commercially available analytical reagents.

[0025] Instruments: ultra-clean bench (BIO-HAZARD, VCM-420, Taiwan, China), electronic analytical balance (METTLER TOLEDO, AB204-E, Switzerland), electromagnetic stirrer (STUART, SM24, UK), cryogenic centrifuge (UNIVERSAL, 32R, HETTICH, Germany) ELISA (MULTISKAN, ASCENT, V1.22, USA), Fluorescence Optical Microscope (OLYMPUS, BH-2, Japan), Scanning Electron Microscope (SEM...

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Abstract

The invention relates to an orthopedic implant with a nano blind hole structure on the surface, wherein the orthopedic implant surface is provided with the nano blind hole structure, the uppermost surface of the orthopedic implant is a nano blind hole layer, the middle thereof is a TiO2 blocking layer, and the lowermost surface thereof is a Ti basal layer. The invention also provides application of the orthopedic implant with the nano blind hole structure on the surface. The invention has the advantages that: the nano blind hole structure is manufactured on the orthopedic implant surface by utilizing a nanotechnology, and the orthopedic implant with the nano blind hole structure has a promoting action on the adhesion proliferation and the differentiation of a mouse C3H10T1 / 2 fibroblast cell line with a multi-directional differentiation potential; and meanwhile, the surface also has a remarkable inhabiting action on staphylococcus epidermidis ATCC 35984 with a positive biomembrane and shows a certain antibacterial action. In sum, the orthopedic implant with the nano blind hole structure on the surface can improve the osseous integration and the antibacterial performance of an orthopedic metal implant material surface.

Description

【Technical field】 [0001] The invention relates to the technical field of medical materials, in particular to an orthopedic implant with a nano-blind hole structure on its surface and its application. 【Background technique】 [0002] From the perspective of biomechanics, the optimal selection of orthopedic implant materials is quite mature, such as medical titanium and titanium alloys, stainless steel, bioceramics, etc. Still in progress, such as various methods of changing the surface roughness of internal plants, hydroxyapatite coating, bioglass coating, and various active polymer materials. However, most of the work done on the surface modification of titanium implants to promote osseointegration and prevent loosening has focused on the preparation of bioactive coatings on the surface, but the coatings failed due to their weak combination with the matrix. As a means of surface strengthening, surface nanoization is to use various physical or chemical methods to refine the s...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/56A61L27/50A61L31/02A61L31/14
Inventor 汤亭亭彭兆祥何国倪嘉桦
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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