Technique for producing medicinal mirabilite by continuous crystallization

Abstract

The invention relates to a technique for producing medicinal mirabilite by continuous crystallization. An on-line infrared computer automatic monitoring system is used for monitoring, and a porous plate liquid balance flowmeter is used for regulation and control, thereby ensuring that the manufacturing process, production facility and product of the medicinal mirabilite satisfy the GMP requirements. The technique comprises the following steps: when the indoor air cleanliness of the production workshop achieves the following indexes: the floating bacteria is less than 100 cfu / m<3>, the sedimentated bacteria is less than 50 cfu / 4 hours, the contact disc of the surface microorganism is less than 25 cfu / disc, the number of suspended particles which is more than 0.5 mu m is less than 350000 / m<3>, and the number of suspended particles which is more than 5 mu m is less than 2900 / m<3>, thus removing mechanical impurities from the downhole-transmitted original mirabilite solution with certain concentration through a three-level pipeline filter, and refining and purifying through an eight-level ion exchanger to obtain the refined mirabilite solution of which the impurity content is lower than 1 ppm; inputting the refined mirabilite solution into a continuous crystallization technical system, and carrying out solid-liquid separation by a strap centrifuge to obtain the medicinal mirabilite crystals in which the content of free water is 0.3-0.5%; and finally, carrying out aseptic packaging by an automatic packaging system.

Description

Technical field: [0001] The invention belongs to the processing field of pharmaceuticals. Background technique: [0002] Glauber's salt, also known as sodium sulfate decahydrate, its chemical formula is: Na 2 SO 4 10H 2 O, English name: hydrous Thenardite. The crystal water content is 55.9%, and the sodium sulfate content is 44.1%. Pure mineral contains Na 2 O 19.3%, SO 3 24.8%. Monoclinic crystal system, usually in the form of granular and massive, and also in the form of shell or film. Colorless and transparent, impurities will dye it into gray, gray green, light yellow, milky white, black and so on. Glassy luster. Streaks white. Hardness 1.5~2.0. The specific gravity is 1.48. Slightly bitter, salty. It loses water of crystallization at 100°C. In dry air, it gradually loses crystal water and turns into white powder anhydrous Glauber's salt, and the flame is dark yellow when burning. Soluble in water and glycerin, insoluble in ethanol. Anhydrous sodium sul...

AI Technical Summary

Problems solved by technology

The technological process adopted in this method is actually to make saltwater into Glauber's salt containing crystal water first, then remove the free water in Glauber's salt, and finally obtain the production process of Glauber's salt containing crystal water; Glauber's salt has high energy consumption and the purity of Glauber's salt is not high, and it is not conducive to large-scale production

[0004] In China Patent No. 97116654.4, a production method of frozen crystallization to produce Glauber's salt containing crystal water is introduced. It goes through technological processes such as dehalogenation, concentration, beach drying, collection, and impurity removal. The method mainly adopts the method of cooling, concentration, and drying , and the temperature is controlled at 18°C ​​in hot days and 10°C in winter and spring. The purpose is to produce Glauber's salt containing crystal water through this method. However, the purity of Glauber's salt produced in this way is not high, and there are disadvantages such as large harvesting sites. factor, it is extremely unlikely to produce hundreds of thousands of tons of

Images