Rare earth upconversion nano crystal/silver difunctional composite nano material, preparation method thereof and application thereof in cancer detection and treatment

A composite nanomaterial, rare earth up-conversion technology, applied in wave energy or particle radiation processing materials, luminescent materials, chemical instruments and methods, etc., can solve the problems of expensive and difficult to realize real-time morphology monitoring

Inactive Publication Date: 2011-01-19
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the biological application of noble metal nanomaterials, there are still difficulties to be solved in the positioning of photosensitive materials, the monitoring of cancer cell morphology, and the detection of photothermal conversion temperature.
Although this problem has been noticed and some soluti

Method used

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  • Rare earth upconversion nano crystal/silver difunctional composite nano material, preparation method thereof and application thereof in cancer detection and treatment
  • Rare earth upconversion nano crystal/silver difunctional composite nano material, preparation method thereof and application thereof in cancer detection and treatment
  • Rare earth upconversion nano crystal/silver difunctional composite nano material, preparation method thereof and application thereof in cancer detection and treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] NaYF 4 :Yb 3+ , Er 3+ / Ag

[0072] 1. Mix 0.78mmol Y(NO 3 ) 3 ·5H 2 O with 0.20mmol Yb(NO 3 ) 3 ·5H 2 O and 0.02mmolEr(NO 3 ) 3 ·5H 2 O was dissolved in 1 ml of methanol at room temperature.

[0073] 2. Add 15ml of oleylamine or oleic acid / oleylamine mixed (1:1) solvent after vigorous stirring;

[0074] 3. Then slowly add 5ml containing NaOH (2.5mmol) and NH 4 F (1 mmol) in methanol was heated to 100°C for 90 minutes to remove methanol.

[0075] 4. The temperature of the mixed solution was raised to 320° C. and kept for one hour while being protected by nitrogen gas. After cooling down to room temperature, it was centrifuged and washed several times, and the centrifuge was dispersed in 10 ml of thioglycolic acid solution, and stirred ultrasonically for 24 hours.

[0076] 5. Centrifuge and wash the thioglycolic acid solution several times with deionized water, and redisperse it in deionized water to obtain NaYF 4 :Yb 3+ , Er 3+ Rare earth nano-luminesce...

Embodiment 2

[0081] NaYF 4 :Yb 3+ , Er 3+ / Ag

[0082] 1. Take 0.78mmol Y (NO 3 ) 3 ·5H 2 O, 0.20mmol Yb(NO 3 ) 3 ·5H 2 O, 0.02mmolEr(NO 3 ) 3 ·5H 2 O, dissolved in 1ml methanol at room temperature.

[0083] 2. After vigorous stirring, add 15ml oleylamine or oleic acid / oleylamine mixed solvent (1:1)

[0084] 3. Then slowly add 5ml containing NaOH (2.5mmol) and NH 4 F (1 mmol) in methanol was heated to 100°C for 90 minutes to remove methanol.

[0085] 4. The temperature of the mixed solution was raised to 320° C. and kept for one hour while being protected by nitrogen gas. After cooling down to room temperature, it was centrifuged and washed several times, and the centrifuge was dispersed in 10 ml of thioglycolic acid solution, and stirred ultrasonically for 24 hours.

[0086] 5. Centrifuge and wash the thioglycolic acid solution several times with deionized water, and redisperse it in deionized water. i.e. get NaYF 4 :Yb 3+ , Er 3+ Rare earth nano-luminescent materials. ...

Embodiment 3

[0091] NaYF 4 :Yb 3+ , Er 3+ / Ag

[0092] 1. Take 0.78mmol Y (NO 3 ) 3 ·5H 2 O, 0.20mmol Yb(NO 3 ) 3 ·5H 2 O, 0.02mmolEr(NO 3 ) 3 ·5H 2 O, dissolved in 1ml methanol at room temperature.

[0093] 2. After vigorous stirring, add 15ml oleylamine or oleic acid / oleylamine mixed solvent (1:1)

[0094] 3. Then slowly add 5ml containing NaOH (2.5mmol) and NH 4 F (1 mmol) in methanol was heated to 100°C for 90 minutes to remove methanol.

[0095] 4. The temperature of the mixed solution was raised to 320° C. and kept for one hour while being protected by nitrogen gas. After cooling down to room temperature, it was centrifuged and washed several times, and the centrifuge was dispersed in 10 ml of thioglycolic acid solution, and stirred ultrasonically for 24 hours.

[0096] 5. Centrifuge and wash the thioglycolic acid solution several times with deionized water, and redisperse it in deionized water. i.e. get NaYF 4 :Yb 3+ , Er 3+ Rare earth nanocrystalline luminescent ...

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PUM

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Abstract

The invention provides a rare earth upconversion nano crystal/silver difunctional composite nano material and a preparation method thereof as well as application thereof in preparation of medicine for treating tumour. The composite nano material can inhibit the growth of tumour tissue and can be used with anti-tumour medicine, thus improving medicine effect and achieving the aim of treatment; thecomposite nano material is difficult to decompose and has good light stability; damage to human body is less, the composite nano material can be taken as heat sensitizing agent and can absorb infrared light, the near infrared region (800-1200nm) is a transmission window of organism tissue, and damage of near infrared laser to human body is far less than that of laser in other wavebands, thus reducing damage to human body, being capable of being used as photothermal conversion agent and being superior when used for diagnosis and treatment on malignant tumour.

Description

technical field [0001] The invention provides a rare earth up-conversion nanocrystal / silver dual-functional composite nanomaterial and a preparation method, and also discloses the application of the substance in the preparation and treatment of tumor drugs, belonging to the field of metal and rare earth nanomaterial technology and application. Background technique [0002] The size, shape and structure control, physical properties and biological applications of noble metal nanomaterials represented by Au and Ag have always been the frontier focus of nanomaterial research. Modern studies have shown that based on the near-infrared photosensitive properties of noble metals, metal nanomaterials can convert absorbed light energy into heat energy through near-infrared laser irradiation. If it is combined with cancer cells, it can increase the temperature in the local area to kill cancer cells and achieve the purpose of cancer treatment. The Halas group in the United States utiliz...

Claims

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Application Information

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IPC IPC(8): C09K11/85C09K11/02A61K49/00A61K49/18A61K41/00A61P35/00G01N21/31
Inventor 董彪宋宏伟王宇白雪徐琳
Owner JILIN UNIV
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