Shell layer dropping type nanometer medicine carrier preparation based on amphiphilic block copolymer and preparation method thereof

Abstract

The invention discloses a shell layer dropping type nanometer medicine carrier preparation based on an amphiphilic block copolymer and a preparation method thereof. The preparation is prepared from the following components in parts by weight: 1 to 20 parts by weight of active ingredient medicines, 10 to 200 parts by weight of amphiphilic block copolymers and 20 to 500 parts by weight of organic solvents. The nanometer medicine micelle carrier preparation is in a core-shell structure, the core of which is a hydrophobic chain segment used for wrapping active ingredients and the shell of which is an amphiphilic block copolymer hydrophilic chain segment, and a hydrophilic segment and a hydrophobic segment in the amphiphilic block copolymer are connected through a disulphide bond S-S. The medicine carrier preparation can be preserved easily and has the advantages of high stability, high medicine cladding ratio, large medicine loading capacity, low toxicity and high medicine bioavailability.

Description

technical field [0001] The invention belongs to the fields of polymer materials and medical engineering, and in particular relates to a shell detachable nano drug carrier preparation based on an amphiphilic block copolymer and a preparation technology thereof. Background technique [0002] Cancer is a common disease that endangers human life and health. With the development of society and economy and the change of human living habits, the incidence and mortality of cancer are on the rise. Chemotherapy is the basic method of cancer treatment. Chemotherapy is of great significance to the treatment of cancer and the control of metastasis of cancer cells. However, chemotherapy also faces many unsolved problems. Low-molecular and macromolecular drugs widely used at present have their own disadvantages: (1) Low-molecular drugs are administered orally or by injection, and the drug concentration in the body in a short period of time exceeds the actual demand, and lacks the selectivi...

AI Technical Summary

Problems solved by technology

Low-molecular and macromolecular drugs widely used at present have their own disadvantages: (1) Low-molecular drugs are administered orally or by injection, and the drug concentration in the body in a short period of time exceeds the actual demand, and lacks the selectivity of entering the human body; fast metabolism , the half-life is short, the concentration in the body will decrease quickly and affect the curative effect, so it needs to be given in large doses, and the high drug concentration will enhance the side effects of the drug

(2) Biomacromolecular drugs are easy to be inactivated by enzymolysis in the body, and the biological half-life is short, requiring repeated administration; also subject to restrictions such as the immune system, tissues, cell membranes, etc., most of them are not easy to pass through these biological barriers, so the biological properties of macromolecular drugs low utilization

[0005] However, polymer nanomicelles also face some shortcomings as drug carriers.

Chemotherapy drugs generally need to enter the tumor cells to produce curative effect. However, the drug release behavior of traditional nanocarriers has no obvious difference between the inside and outside of the cells. Most of the drugs are released outside the cells, resulting in low bioavailability of drugs and side effects. larger

The current common stimuli-responsive nanomicelles cannot distinguish between intracellular and extracellular environments, so it is of great significance to study smart polymer nanomicelles that can be released locally in tumor cells as drug carriers

Images