Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage

A brain surgery and coating technology, applied in the field of medical devices, can solve the problems of affecting the effect of hemostasis, poor adhesion between blood clots and tissues, and poor hemostasis effect of active bleeding, so as to achieve rapid closure of wound tissue fluid exudation, Effects of Avoiding Cerebrospinal Fluid Extravasation

Inactive Publication Date: 2011-01-26
王庆彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First of all, from the aspect of application, this hemostatic material is mainly limited to the hemostasis of skin or soft tissue wounds, and the hemostasis of tissues and organs in the deep part of the body cavity, especially the hemostasis under endoscopy (such as minimally invasive endoscopy, colonoscopy and laparoscopy). During operation) there is still lack of effective means; the second, from the preparation method, epichlorohydrin is a colorless oily liquid, toxic and anesthetic, so producing this product is unfavorable to the environment, and the production cost is also higher; the third, from In terms of hemostatic effect, because its water absorption is not strong enough, the water absorption rate is...

Method used

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  • Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage
  • Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage
  • Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Gel Applicator Kit:

[0066] 1) The first fluid component: boric acid buffer solution (pH 6; 5ml) of polylysine (0.1g);

[0067] 2) The second fluid component: phosphate buffer (pH11; 5ml), in which dexamethasone (0.1g) is dissolved;

[0068] 3) Solid component: polytrimethylene carbonate and polylactic acid copolymer (2g; weight average molecular weight 12KD);

[0069] 4) Coating tools: (such as figure 2 shown).

[0070]Preparation: Dissolve 0.1g polylysine powder in 5ml boric acid buffer solution with a pH value of 6, then dissolve 0.1g dexamethasone powder in 5ml phosphate buffer solution with a pH value of 11, and fill them in In two syringes 410 and 420; weigh 2g of polytrimethylene carbonate and polylactic acid copolymer powder with a weight average molecular weight of 12KD and put it in the third container 30; configure coating tools; seal the package; irradiate sterilization;

[0071] Application: Before use, dissolve the solid component 31 in the third con...

Embodiment 2

[0073] Gel Applicator Kit:

[0074] 1) The first fluid component: boric acid buffer solution (pH 10; 2ml) of polylysine (0.04g);

[0075] 2) The second fluid component: phosphate buffer (pH 4; 5ml);

[0076] 3) Solid component: polyethylene glycol polybranch isomer (0.7g; weight average molecular weight 30KD);

[0077] 4) Coating tools: (such as figure 2 shown).

[0078] Preparation: Dissolve 0.04g of polylysine powder in 2ml of borate buffer solution with pH value of 10, then fill 5ml of phosphate buffer solution with pH value of 4 into two syringes 410 and 420 respectively; weigh 0.7g polyethylene glycol polybranched isomer powder with a weight average molecular weight of 30KD is packed in a third container 30; coating tools are configured; sealed packaging; irradiation sterilization;

[0079] Application: Before use, dissolve the solid component 31 in the third container 30 into the second fluid component 21 in the syringe 420, and at the same time, install a tee and a...

Embodiment 3

[0081] Gel Applicator Kit:

[0082] 1) The first fluid component: boric acid buffer solution (pH 12; 5ml) of dimerized lysine (0.2g);

[0083] 2) The second fluid component: phosphate buffer (pH 3; 5ml);

[0084] 3) Solid components: gelatin (0.1g) and gelatin protein (1g; weight average molecular weight 30KD);

[0085] 4) Coating tools: (such as figure 2 shown).

[0086] Preparation: Dissolve 0.2g of dimerized lysine powder in 5ml of borate buffer solution with a pH value of 12, then fill 5ml of phosphate buffer solution with a pH value of 3 into two syringes 410 and 420 respectively; weigh 0.1g of white gelatin powder and 1g of gelatin protein powder with a weight average molecular weight of 30KD are packed in the third container 30; coating tools are configured; sealed packaging; irradiation sterilization;

[0087] Application: Before use, the solid component 31 in the third container 30 is dissolved in the second fluid component 21 in the syringe 420, and the front en...

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Abstract

The invention relates to a gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage, comprising a first fluid component in a first buffer solution which contains lysine, dimeric lysine or polylysine and has the pH value of 3-12 in a first container, a second fluid component of a second buffer solution with the pH value of 3-12 in a second container, a combined solid component which is composed of poly (trimethylene carbonate), polylactic acid, polyethylene glycol, polyethylene glycol polytomy isomer, polyurethane, gelatine, polyphosphate, polyglycolic acid and copolymer thereof and blend thereof in a third container as well as a coating tool. When the first fluid component, the second fluid component and the solid component are mixed, gel is formed, and the gel is directly coated onto the part used for preventing brain surgery cerebrospinal fluid leakage.

Description

technical field [0001] The invention relates to the field of medical instruments, in particular to a surgical kit for hemostasis and anti-seepage. technical background [0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will be lost, and it is necessary to use hemostatic means in time. The use of biocompatible absorbable hemostatic materials to stop bleeding on bleeding wounds is a common means of hemostasis, and there is an urgent need for hemostasis in surgical hemostasis, trauma, first aid, and home self-help hemostasis. It can be seen that providing a safe, The importance of effective, easy-to-use, and low-cost hemostatic materials to human health. Cerebrospinal fluid leakage is one of the complications after brain surgery and spinal surgery. Continuous cerebrospinal fluid leakage will hinder the healing of the incision. If the treatment is not timely or handled properly, it may cause wound healing, wound infection, meni...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/26A61L15/20A61L15/18A61L15/42A61L15/44
Inventor 刘泊志王庆彬
Owner 王庆彬
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