Preparation method of magnetic mesoporous phosphorite microsphere material

A technology of mesoporous apatite and microspheres, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc. The morphology is not easy to control and other problems, to achieve the effects of excellent biocompatibility and biological activity, good magnetic properties, and uniform particle size distribution

Inactive Publication Date: 2011-01-26
SHANGHAI NORMAL UNIVERSITY
View PDF4 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the defect that the surface morphology of the magnetic mesoporous hydroxyapatite microspheres prepared in the prior art is not easy to control and affects its drug slow-release performance and biodegradability, the present invention proposes a method using shells as raw materials, using in-situ A new method for preparin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of magnetic mesoporous phosphorite microsphere material
  • Preparation method of magnetic mesoporous phosphorite microsphere material
  • Preparation method of magnetic mesoporous phosphorite microsphere material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Preparation of calcium chloride solution containing shell organic matter: first remove impurities on the surface of shells with a brush, and rinse with tap water. After sanding off the shell layer and prism layer, ultrasonication was performed for 5 min, and then cleaned with deionized water and absolute ethanol, and dried in a blast drying oven at 60 °C for 48 h to obtain a shiny shell nacre. Soak the shell nacre in 1.0 mol / L HCl solution for 1 day. Filter with a Buchner funnel to filter out the shell organic matter that is insoluble in hydrochloric acid. Add 1.0 mol / L NaOH solution dropwise until the pH value of the filtrate is 7.0, then dilute with deionized water until the calcium ion concentration in the solution is 0.25 mol / L, and finally obtain the CaCl containing shell organic matter 2 solution.

[0024] 2. Preparation of sodium carbonate solution: 5.30 g of anhydrous sodium carbonate (Na 2 CO 3 ) was dissolved in 200 mL deionized water to obtain a sodium...

Embodiment 2

[0030] 1. Preparation of calcium chloride solution containing shell organic matter: first remove impurities on the surface of shells with a brush, and rinse with tap water. After grinding off the shell layer and prism layer with sandpaper, ultrasonic for 5 min, then cleaned with deionized water and absolute ethanol, and dried at 60°C for 48 h in a blast drying oven to obtain a shiny shell nacre. Soak the shell nacre in 1.0 mol / L HCl solution for 1 day. Filter with a Buchner funnel to filter out the shell organic matter that is insoluble in inorganic acids. Add 1.0 mol / L NaOH solution dropwise until the pH of the filtrate is 7.0, then dilute with deionized water until the concentration of calcium ions in the solution is 0.10 mol / L, and finally obtain CaCl containing shell organic matter 2 solution.

[0031] 2. Preparation of sodium carbonate solution: 2.12 g of anhydrous sodium carbonate (Na 2 CO 3 ) was dissolved in 200 mL deionized water to obtain a sodium carbonate solut...

Embodiment 3

[0038] 1. Preparation of calcium chloride solution containing shell organic matter: first remove impurities on the surface of shells with a brush, and rinse with tap water. After grinding off the shell layer and prism layer with sandpaper, ultrasonic for 5 min, then cleaned with deionized water and absolute ethanol, and dried at 60°C for 48 h in a blast drying oven to obtain a shiny shell nacre. Soak the shell nacre in 1.0 mol / L HCl solution for 1 day. Filter with a Buchner funnel to filter out the shell organic matter that is insoluble in inorganic acids. Add 1.0 mol / L NaOH solution dropwise until the pH value of the filtrate is 7.0, then dilute with deionized water until the calcium ion concentration in the solution is 0.25 mol / L, and finally obtain the CaCl containing shell organic matter 2 solution.

[0039] 2. Preparation of sodium carbonate solution: 5.30 g of anhydrous sodium carbonate (Na 2 CO 3 ) was dissolved in 200 mL deionized water to obtain a sodium carbonate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of inorganic non-metallic materials and medical materials, and discloses a preparation method of a magnetic mesoporous phosphorite microsphere material. The preparation method adopts an in situ template sacrificial method with shell as a raw material, and comprises the following steps of: preparing magnetic calcium carbonate microspheres by using an in situ compounding technique first; and then treating the magnetic calcium carbonate microspheres by using phosphate buffer solution to convert the magnetic calcium carbonate microspheres into magnetic mesoporous phosphorite microspheres. The magnetic mesoporous phosphorite microspheres have the advantages of larger specific surface area, higher magnetic performance, high medicament controlled-release characteristics, magnetic performance, biocompatibility and bioactivity, and can be used in the field of magnetic targeting medicament carrier, magnetic thermotherapy, bone repair materials and the like; the shell is used as the raw material to reduce the cost; and the preparation processes are performed at low temperature and normal pressure, so the preparation method not only saves energy, but also generates no chemical substances which can pollute the environment.

Description

technical field [0001] The invention relates to the fields of inorganic non-metallic materials and medical materials, and specifically discloses a preparation method of a magnetic mesoporous apatite microsphere material. Background technique [0002] Apatite is the main inorganic component of hard tissues such as human bones and teeth. It has good biocompatibility, biological activity, no toxic side effects, and no immune response. After implantation in the body, it can promote the growth of new bone. It is widely used in human hard tissue replacement materials and repair materials. In 1992, Kresge and Beck of Mobil Company used the supramolecular structure formed by the alkyl quaternary ammonium salt cationic surfactant in the solution as the template agent, and prepared the silicon-MCM-41 mesoporous molecular sieve through the sol-gel process [ Nature 359 (1992): 710~712]. The emergence of mesoporous materials has expanded the pore size range of molecular sieves from mi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C01B25/32
Inventor 郭亚平姚勇波郭亚军褚联峰
Owner SHANGHAI NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap