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Method for purifying arecoline

A purification method and technology for arecoline are applied in the field of separation of natural products, can solve the problems of high cost and low purity of arecoline, and achieve the effects of increasing content, facilitating high-speed countercurrent chromatographic separation, and reducing dosage

Inactive Publication Date: 2011-02-09
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing natural extraction of arecoline process method, the obtained arecoline purity is not high or the cost is relatively high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Betel nut raw material, pitted and pulverized, 1kg was put into a flask, added 5L of 50% ethanol solution, refluxed and extracted 3 times, each time for 1 hour, combined the extracts, recovered ethanol under reduced pressure with a rotary evaporator until no alcohol was found, added the concentrated solution to Adjust ph5 with hydrochloric acid solution, filter, add AB-8 macroporous resin adsorption column, punch with equal column volume water, collect the next column liquid, adjust ph8 with ammonia water, add 1 times the amount of chloroform to mix, transfer to a separatory funnel for separation, and collect chloroform layer, extracted 4 times, combined the extracts, and recovered chloroform under normal pressure with a rotary evaporator to obtain an oily areca nut extract. Take chloroform, methanol, water, mix according to the ratio of 8:13:6, after layering in the separatory funnel, take the upper phase solvent to dissolve the betel nut extract, the lower phase is use...

Embodiment 2

[0021] Betel nut raw material, pitted and pulverized, 1 kg was put into a flask, added 5L of 50% methanol solution, refluxed and extracted 3 times, each time for 1 hour, combined the extracts, recovered ethanol under reduced pressure with a rotary evaporator, until no alcohol was found, the concentrated solution was added Adjust ph3 with hydrochloric acid solution, filter, add D101 macroporous resin adsorption column, press with water equal to the column volume, collect the next column liquid and adjust ph7 with ammonia water, add 2 times the amount of chloroform to mix, transfer to a separatory funnel for separation, collect the chloroform layer, Extracted 3 times, combined the extracts, recovered the chloroform with a rotary evaporator under normal pressure, and obtained the oily areca nut extract. Take chloroform, methanol, water, mix according to the ratio of 7:10:5, after layering in the separatory funnel, take the upper phase solvent to dissolve the betel nut extract, the...

Embodiment 3

[0023] Betel nut raw material, pitted and pulverized, put 1kg into a flask, add 8L of 30% ethanol solution, reflux extraction twice, each time for 1 hour, combine the extracts, use a rotary evaporator to recover ethanol under reduced pressure until no alcohol, add the concentrated solution Hydrochloric acid solution to adjust ph4, filter, add LSA-7 macroporous resin adsorption column, press with equal column volume water, collect the next column liquid, adjust ph8 with ammonia water, add 2 times the amount of chloroform to mix, transfer to a separatory funnel for separation, and collect chloroform layer, extracted 3 times, combined the extracts, and recovered chloroform at normal pressure with a rotary evaporator to obtain an oily areca nut extract. Take n-hexane, ethyl acetate, methanol, water, mix according to the ratio of 1:3:3:1, after layering in the separatory funnel, remove the lower phase solvent to dissolve the betel nut extract, and use the upper phase as the mobile p...

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PUM

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Abstract

The invention provides a method for purifying arecoline, which comprises the steps: taking the arecoline material, removing the core, crushing, adding 5-10 times of alcohol or methanol solution with the concentration of 30-50%, refluxing and extracting for 2-3 times, recovering a reagent from an extracting solution, adjusting the pH of a concentrated solution by hydrochloric acid to be 3-5, adding macroporous resins for absorption, readjusting the pH of a lower column liquid to be 7-8, adding chloroform for extraction, using the extracting solution to recover the chloroform to obtain an oily betel nut extract, selecting a chloroform-methanol-water solvent system or a normal hexane ethyl acetate methanol-water solvent system, adopting a high-speed counter current chromatograph for separation, freezing, drying to obtain the high-content arecoline. The method adopted for producing the arecoline has the advantages of short production cycle and low cost.

Description

Technical field: [0001] The invention belongs to the field of separation of natural products, in particular to a method for purifying arecoline. Background technique: [0002] Arecoline (arecoline, 1), the chemical name is IV-methyl-1, 2, 5, 6. Methyl tetrahydronicotinate, it is a colorless, odorless, light yellow oily liquid at room temperature, with a boiling point of 209° , molecular weight: 155.20. Miscible with water, ethanol and ether, soluble in chloroform. [0003] Arecoline is an alkaloid extracted from the palm plant Areca nut (Areca catecthu L.). It has the functions of deworming, sterilization, antithrombosis and antiatherosclerosis. [0004] In the existing natural extraction process of arecoline, the purity of the obtained arecoline is not high or the cost is relatively high. [0005] Such as patent (Application No. 200610041917) "New Technology for Scale Extraction and Separation of Arecoline", the method disclosed in this patent is to get the betel nut, a...

Claims

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Application Information

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IPC IPC(8): C07D211/78
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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