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Chlorine dioxide skin gel and preparation method thereof

A chlorine dioxide and gel technology, which is applied to skin diseases, active ingredients of peroxide, and pharmaceutical formulations, etc., can solve the problems of wound sterilization, unsatisfactory and long-lasting disinfection effect, difficult wound ulcer healing, poor effect, etc.

Active Publication Date: 2011-02-16
宋健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current external disinfectants such as disinfectant alcohol, iodine and ointment containing antibiotics are less effective after use, and the wound sterilization and disinfection effects are not ideal and lasting, and it is difficult to heal the wound ulcer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment one: a kind of preparation method of chlorine dioxide skin gel, adopt following processing steps, formula ratio is counted by weight parts:

[0020] (1) First mix 0.15 parts of disodium edetate with 100 parts of purified water to obtain solution A;

[0021] (2) Take half of the total amount of solution A and heat it to 83°C, then cool it to room temperature, and place it in a refrigerator at 2°C for 8 hours to obtain a clear solution B;

[0022] (3) Mix the remaining half of the total amount of solution A with 5 parts of glycerin to obtain solution C;

[0023] (4) Swell 1 part of Carbomer 940 in solution C and stir at a stirring speed of 100 rpm for 12 hours; then adjust the pH value with 14% aqueous sodium hydroxide solution To 6.5, after the stirring is finished, a gel base is obtained;

[0024] (5) Mix 1 part of chlorine dioxide aqueous solution with solution B and gel base and stir evenly to obtain a chlorine dioxide skin gel semi-finished product; the ...

Embodiment 1

[0026] The chlorine dioxide skin gel that embodiment 1 obtains carries out antibacterial test in vitro and shows, kills Pseudomonas aeruginosa, Salmonella choleraesuis in 10 seconds; Kills Escherichia coli, Staphylococcus aureus, Neisseria gonorrhoeae, Treponema pallidum in 2 minutes , Trichomonas vaginalis, and Streptococcus faecalis; the killing rate is 99.99%. 5 points to kill HbsAg hepatitis virus and Bacillus subtilis spores, the killing rate is 100%. When to the bacteriostasis test of mould, compared chlorine dioxide aqueous solution and the bacteriostatic effect time of the present invention: around the transparent bacteriostatic circle, after 24 hours of cultivation again, the compound change of chlorine dioxide aqueous solution is fuzzy, and the present invention is still transparent , show that the bacteriostasis time of the present invention obviously prolongs, and this is because the present invention first kills microorganisms the same as the chlorine dioxide aque...

Embodiment 2

[0027] Embodiment two: a kind of preparation method of chlorine dioxide skin gel adopts the following process steps, and the formula ratio is calculated by weight parts:

[0028] (1) First mix 0.4 parts of disodium edetate with 200 parts of purified water to obtain solution A;

[0029] (2) Take half of the total amount of solution A and heat it to 87°C, then cool it to room temperature, and place it in a refrigerator at 6°C for 12 hours to obtain a clear solution B;

[0030] (3) Mix the remaining half of the total amount of solution A with 10 parts of glycerin to obtain solution C;

[0031] (4) Swell 3 parts of Carbomer 940 and stir in solution C, the stirring speed is 120 rpm, and the stirring time is 8 hours; adjust the pH value to 7.5, after the stirring is finished, a gel base is obtained;

[0032] (5) Mix 15 parts of chlorine dioxide aqueous solution with solution B and gel base and stir evenly to obtain a chlorine dioxide skin gel semi-finished product; the stirring sp...

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Abstract

The invention relates to a preparation method of a chlorine dioxide skin gel, which is characterized by comprising the following steps of: mixing ethylene diamine tetraacetic acid with purified water to obtain a solution A; heating and then cooling one half of the solution A, and placing in a refrigerator to obtain a solution B; mixing the other half of the solution A with glycerol to obtain a solution C; swelling Carbomer 940 in the solution C and regulating the pH value by using a sodium hydroxide aqueous solution to obtain a gel substrate; uniformly stirring a chlorine dioxide aqueous solution, the solution B and the gel substrate after mixing, and then carrying out vacuum deaeration to obtain the chlorine dioxide skin gel. The chlorine dioxide skin gel has the advantages of rapidity and durability, safety and no toxicity, wide application and high efficiency and the functions of sterilization, disinfection, bleaching and deodorization and is hardly influenced by environment (such as temperature, pH value, organic matter and the like) when in use.

Description

technical field [0001] The invention relates to a skin gel, in particular to a chlorine dioxide skin gel used for skin sterilization and external disinfection and a preparation method thereof, belonging to the technical field of bactericidal disinfectants. Background technique [0002] In daily life, the surface of the skin often causes skin trauma and skin ulcers due to trauma, disease (such as diabetes) and other factors. Long-term ulcers are difficult to heal; external genital infections caused by unclean sex life, genital ulcers and infections caused by condyloma acuminatum, genital herpes, syphilis, etc., in addition to oral antibiotics for treatment, external disinfection and sterilization measures are also very important. However, current external disinfectants such as disinfectant alcohol, iodine and antibiotic-containing ointment are less effective after use, and the wound sterilization and disinfection effects are not ideal and lasting, and it is difficult to make...

Claims

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Application Information

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IPC IPC(8): A61J3/00A61K33/40A61K47/18A61K9/06A61P31/00A61P17/00A61K47/32
Inventor 宋健
Owner 宋健
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