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Application of needle-leaved polyprenol in preparing medicines for preventing and treating Alzheimer disease

A technology for Alzheimer's disease and polyprenol, which is applied in the field of medicine to achieve the effects of wide sources, less pollution, and low development and utilization costs

Inactive Publication Date: 2011-04-27
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These treatments can temporarily improve memory, but due to their own limitations, it is difficult to apply in the long-term clinically

Method used

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  • Application of needle-leaved polyprenol in preparing medicines for preventing and treating Alzheimer disease
  • Application of needle-leaved polyprenol in preparing medicines for preventing and treating Alzheimer disease
  • Application of needle-leaved polyprenol in preparing medicines for preventing and treating Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the extraction of Acerola polyprenol

[0016] The extraction of coniferous polyprenol is the same as the method recorded in Chinese Patent Publication No. CN101654398A. After the fresh conifers are dried and pulverized, they are extracted with petroleum ether, saponified with dilute alkali, extracted with petroleum ether, concentrated under reduced pressure, dissolved in acetone, and removed by cooling. Coniferous polyprenol was prepared after impurity, ethanol extraction, acetone dissolution, cryoprecipitation separation and filter cake vacuum drying.

Embodiment 2

[0017] Embodiment 2: Acerola polyprenol soft capsule

[0018] Coniferous polyprenol is used as the active ingredient of the medicine, and refined vegetable oil, emulsifier, gelatin, glycerin, coloring agent and other auxiliary materials are added, and the soft capsule dosage form is made through batching, gelatinization, pilling, shaping and drying according to the conventional process.

Embodiment 3

[0019] Example 3: Protective effect of acerola polyprenol on PC12 nerve cell injury induced by β-amyloid protein

[0020] 1 Materials and methods

[0021] 1.1 Experimental materials

[0022] Coniferous polyprenol, 76.2% pure, formulated in DMSO to 10 -2 mol / L solution, stored at 4°C for future use. Aβ 1-42 , purchased from Beijing Boaosen Company, prepared 1g / L mother solution with normal saline, sterilized by filtration with 0.22μm microporous membrane, incubated at 37°C for 7 days, "aged" into a neurotoxic aggregation state, - Store at 20°C for later use.

[0023] 1.2 Drug handling

[0024] After counting PC12 cells in the logarithmic growth phase, 4×10 5 / mL density inoculated in 96-well culture plate, 150 μl per well. The cells were divided into 3 groups: the normal control group, adding an equal amount of DMSO solution; the model control group, adding 7-day-aged Aβ 1-42 Incubate at 50 μmol / L for 48 hours; in the polyprenol group, add coniferous polyprenol at a fin...

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Abstract

The invention belongs to the technical field of medicines, and discloses an application of needle-leaved polyprenol in preparing medicines for preventing and treating Alzheimer disease. The needle-leaved polyprenol is obtained from needle leaves of pinaceae plants such as pinus, picea, larch, fir and cedar and the like by extraction, separation and purification. The needle-leaved polyprenol is long-chain polyterpene compound formed by 14-24 isopentene group units. Cell and animal experimental results indicates that the needle-leaved polyprenol has functions of preventing and treating the Alzheimer disease, i.e., the needle-leaved polyprenol has a protection function for damage of pheochromocytoma (PC) 12 nerve cells caused by amyloid-beta protein, and can improve the passive avoidance memory capability and space learning memory capability of demented mice. Therefore, the needle-leaved polyprenol can be used for preparing the medicines for preventing and treating the Alzheimer disease.

Description

technical field [0001] The invention relates to a new medical application of acerola polyprenol, in particular to the application of acerola polyprenol in the preparation of drugs for preventing and treating Alzheimer's disease, and belongs to the technical field of medicine. Background technique [0002] Alzheimer's disease, also known as senile dementia, is a common degenerative disease of the central nervous system, manifested as progressive decline in memory and cognitive function, abnormal behavior and social impairment. With the prolongation of human life expectancy and the arrival of the age of social aging, the incidence of Alzheimer's disease is increasing day by day, and it has become the fourth leading killer of the elderly after heart disease, cancer and stroke. Prevention And the treatment of Alzheimer's disease has become a hot issue of concern all over the world. At present, the main treatment measures for Alzheimer's disease include cholinesterase inhibitor ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P25/28
Inventor 郑光耀薄采颖周维纯
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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