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Scopolamine transdermal patch and preparation method thereof

A technology of scopolamine and transdermal patch, applied in the field of scopolamine transdermal patch and its preparation, can solve the problems of long dissolution time, long onset time, potential safety hazards, etc. The effect of production volume

Inactive Publication Date: 2011-05-04
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The disadvantage of the above-mentioned scopolamine transdermal patch is that it has a five-layer structure, and the structure is relatively complicated; the release of the drug is controlled by a controlled-release membrane, and the onset time is long, so it needs to be pasted and used 5 to 6 hours before taking a vehicle; Polyisobutene and low-molecular-weight polyisobutene are dissolved with heptane, which takes a long time to dissolve; high-pressure homogenization (20-40MPa) of the homogenizer has potential safety hazards

Method used

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  • Scopolamine transdermal patch and preparation method thereof
  • Scopolamine transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Weigh 30g of absolute ethanol and add it to 70g of polyacrylic acid resin, stir and dissolve; then add in 290g of acrylic pressure-sensitive adhesive and stir evenly, set aside;

[0027] (2) Take by weighing 10g azone and 15g propylene glycol, dissolve with 20g cyclohexane, then add 15g pulverized scopolamine (crushed through a 100 mesh sieve), after stirring evenly, set aside;

[0028] (3) Add the solution obtained in step (2) to the solution obtained in step (1); rinse the container of step (2) with 5g cyclohexane and add it to the solution obtained in step (1), stir for 30min; The machine is homogenized 3 times under the pressure of 12Mpa;

[0029] (4) Dry and coat the above-mentioned homogenized solution on a release film coated with silicon polymer on one side with a coater to form a drug layer. The drying temperature of the coater is 35° C., and the thickness of the drug layer is 40 μm; Then clad with aluminized film;

[0030] (5) Cut into 2.5cm in diameter ...

Embodiment 2

[0032] (1) Weigh 40g of absolute ethanol and add it to 60g of polyacrylic acid resin, stir and dissolve; then add in 300g of acrylic pressure-sensitive adhesive and stir evenly, set aside;

[0033] (2) Take by weighing 15g azone and 20g propylene glycol, dissolve with 15g cyclohexane, then add 15g pulverized scopolamine (crushed through a 100 mesh sieve), stir evenly, and set aside;

[0034] (3) Add the solution obtained in step (2) to the solution obtained in step (1); rinse the container of step (2) with 5g cyclohexane and add it to the solution obtained in step (1), stir for 30min; The machine is homogenized 3 times under the pressure of 10Mpa;

[0035] (4) Dry and coat the above-mentioned homogenized solution on a release film coated with silicon polymer on one side with a coater to form a drug layer. The drying temperature of the coater is 45° C., and the thickness of the drug layer is 45 μm; Then clad with aluminized film;

[0036] (5) Cut into 2.5cm in diameter with a...

Embodiment 3

[0038] (1) Weigh 50g of absolute ethanol and add it to 50g of polyacrylic acid resin, stir and dissolve; then add in 310g of acrylic pressure-sensitive adhesive and stir evenly, set aside;

[0039] (2) Take by weighing 20g azone and 25g propylene glycol, dissolve with 10g cyclohexane, then add 15g pulverized scopolamine (crushed through a 100 mesh sieve), stir evenly, and set aside;

[0040] (3) Add the solution obtained in step (2) to the solution obtained in step (1); rinse the container of step (2) with 5g cyclohexane and add it to the solution obtained in step (1), stir for 30min; The machine is homogenized 5 times under the pressure of 12Mpa;

[0041] (4) Dry and coat the above-mentioned homogenized solution on a release film coated with silicon polymer on one side with a coater to form a drug layer. The drying temperature of the coater is 55° C., and the thickness of the drug layer is 45 μm; Then clad with aluminized film;

[0042] (5) Cut into 2.5cm in diameter with a...

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Abstract

The invention provides a scopolamine transdermal patch, composed of a back lining, a drug layer and an anti-sticky layer which are sequentially laminated, wherein the drug layer comprises scopolamine, skin penetration enhancer, pressure-sensitive adhesive and polyacrylic resin in the weight ratio of 15: (16-64): (150-420): (50-100). The invention also provides a preparation method of the scopolamine transdermal patch. The invention has the advantages that the scopolamine transdermal patch is simple in structure, has quick effect and can be pasted one hour before taking vehicle transportation, thus reducing pasting time for patients; and the preparation method is simple, thus reducing production time, improving production capacity and reducing energy consumption.

Description

technical field [0001] The invention relates to a scopolamine transdermal patch for treating motion sickness and a preparation method thereof. Background technique [0002] Motion sickness is a general term for motion sickness, seasickness, airsickness, and diseases caused by swinging, bumping, rotating, and accelerated motion caused by various reasons. Scopolamine is an anti-M-cholinergic receptor drug, which can relieve smooth muscle spasm (including relieving vascular spasm and improving microvascular circulation); inhibit gland secretion; relieve the inhibition of the vagus nerve on the heart. The patch made of scopolamine can play a very good preventive role when used in cars, boats, planes, etc. [0003] The existing scopolamine transdermal patch has a five-layer structure, including a backing, a reservoir layer, an adhesive layer, a release-controlling film and an anti-adhesive layer. Its preparation method is as follows: after extracting scopolamine hydrobromide wit...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/46A61K47/22A61P1/08
Inventor 陈鹏汪洪湖
Owner 蚌埠丰原涂山制药有限公司
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