Preparation method of micro-pills prepared from cassia twig and tuckahoe

Abstract

The invention discloses a preparation method of micro-pills prepared from cassia twig and tuckahoe, which comprises the following steps: extracting volatile components from cassia twig and moutan bark; mixing the dregs of the cassia twig and moutan bark with red peony root and peach kernels, boiling with water, merging the obtained decoction and the liquid medicine of the cassia twig and moutan bark after the volatile components are extracted, concentrating, depositing in alcohol, filtering, and taking the filtered solution; carrying out inclusion on the volatile components of the cassia twig and moutan bark to obtain inclusion complexes; and respectively preparing a powdered extract, an extract and a fluid extract by using the filtered solution, fine tuckahoe powder and the inclusion complexes, preparing female mold pills by using the powdered extract as a mold core and using the extract as a bonding agent, preparing micro-pills by using the fluid extract as a spouting increasing agent and using a fluidized bed granulation method, and coating to obtain the micro-pills prepared from cassia twig and tuckahoe. By the invention, the effective components of the medicines are effectively extracted, the medical effect is improved, and the performance quality of products is stable. By using the pure powdered extract prepared from cassia twig and tuckahoe as the mold core, the medicine carrying content of the micro-pills is high; by using the fluidized bed granulation method for preparing the micro-pills, the yield is high; and after the micro-pills are coated, the hygroscopicity of the micro-pills is obviously reduced, thereby solving the problem of moisture absorption of a pure extract preparation.

Description

technical field [0001] The invention relates to a preparation method of cinnamon twigs and poria preparations, in particular to a preparation method of cinnamon twigs and poria pellets, and belongs to the technical field of pharmacy. Background technique [0002] Guizhi Fuling Pills is published in the chapter "Golden Relics: Syndrome and Syndrome of Women's Pregnancy". Zhang Zhongjing used it to treat women's post-pregnancy leaks and restless fetal movement because of its function of promoting blood circulation and removing traces, eliminating symptoms and accumulation. In the prescription, Guizhi is used as the main medicine, warming the blood vessels; peach kernel and paeonol, promoting blood circulation and removing blood stasis; red peony root, softening the liver and restraining yin, harmonizing the camp and health; Poria cocos, invigorating the spleen and nourishing the middle, promoting dampness and helping Gui to pass through. In recent years, a large number of expe...

AI Technical Summary

Problems solved by technology

Studies have shown that compared with other oral preparations, pellet preparations have many advantages, such as improving the bioavailability of drugs, good absorption reproducibility, easy to achieve the expected drug release rate, achieving ideal blood drug concentrations, and avoiding drug exposure. The hazards caused by sudden release, etc., but the preparation process of my country's pellets has disadvantages such as backward technology, high work intensity, and low efficiency.

Patents 200510200475 and 200610059817 have made some improvements to the preparation of cassia twigs and poria pellets, but in the above-mentioned patent materials, cassia twigs use alcohol or water to extract active ingredients, and cassia twigs mainly contain volatile oil, in which cinnamic aldehyde and cinnamic acid content Higher, cinnamon aldehyde, cinnamon oil all have significant activity of inhibiting platelet aggregation, have analgesic effect etc., if use above-mentioned method, the active pharmaceutical ingredient in cassia twig will inevitably be lost, thereby reduce drug effect

Moreover, the spheronization-extrusion method is generally used to prepare micropills in China, and there is no literature on the preparation of micropills by using cinnamon twig and poria extract powder and extract

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