Sodium iron chlorophyllin-chitosan/sodium alginate microcapsules and preparation method thereof

A technology of sodium iron chlorophyllide and sodium alginate, which is applied in the field of preparation of medicinal and food pigments, can solve the problems such as microcapsules of sodium iron chlorophyllide that have not yet been seen, and achieve improved drug efficacy and bioavailability, and enhanced stability The effects of safety and preparation process safety

Inactive Publication Date: 2011-07-13
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research report on the preparation of iron sodium chlorophyllinate microcapsules using chitosan-sodium alginate as the capsule material

Method used

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  • Sodium iron chlorophyllin-chitosan/sodium alginate microcapsules and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Sodium ferric chlorophyllin was dissolved in 1.5 times of 1.5% sodium alginate solution, and the resulting solution was placed in vegetable oil containing 1.0 g of Span-60, stirred at 600 r / min, and emulsified for 20 min. Aqueous acetic acid solution containing 2.0% chitosan and calcium chloride was added dropwise, stirring was continued for 30 min, and the mixture was allowed to stand for 2 h to remove the oil phase. The microcapsules were washed three times with petroleum ether and isopropanol respectively, filtered with suction, and dried at room temperature to obtain iron sodium chlorophyllinate-chitosan / sodium alginate microcapsules.

[0023] Carry out microcapsule evaluation: its appearance is a uniform ellipsoid see figure 1 , evenly dispersed; the particle size distribution reaches 70% in the range of 75 μm to 100 μm; the release rate of the microcapsules in vitro is 50% within 4 hours.

Embodiment 2

[0025] Sodium ferric chlorophyllin was dissolved in 1.5 times of 1.8% sodium alginate solution, and the resulting solution was placed in vegetable oil containing 1.0 g of Span-60, stirred at 700 r / min, and emulsified for 20 min. Aqueous acetic acid solution containing 2.0% chitosan and calcium chloride was added dropwise, stirring was continued for 30 min, and the mixture was allowed to stand for 2 h to remove the oil phase. The microcapsules were washed three times with petroleum ether and isopropanol respectively, filtered with suction, and dried at room temperature to obtain iron sodium chlorophyllinate-chitosan / sodium alginate microcapsules.

[0026] Carry out microcapsule evaluation: its appearance is a uniform ellipsoid see figure 1 ; The particle size distribution reaches 60% in the range of 100±0.65μm; the release rate of microcapsules in vitro is 40% within 4 hours.

Embodiment 3

[0028] Sodium ferric chlorophyllin was dissolved in 1.5 times of 2.0% sodium alginate solution, and the resulting solution was placed in vegetable oil containing 1.0 g of Span-60, stirred at 900 r / min, and emulsified for 20 min. Aqueous acetic acid solution containing 2.0% chitosan and calcium chloride was added dropwise, stirring was continued for 30 min, and the mixture was allowed to stand for 2 h to remove the oil phase. The microcapsules were washed three times with petroleum ether and isopropanol respectively, filtered with suction, and dried at room temperature to obtain iron sodium chlorophyllinate-chitosan / sodium alginate microcapsules.

[0029] The microcapsules were evaluated: the appearance was uniform ellipsoid and broken capsule, resulting in irregular capsule shape; the particle size reached 70% in the range of 75±0.74 μm; the release rate of microcapsules in vitro was 60% in 4 hours.

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Abstract

The invention discloses sodium iron chlorophyllin-chitosan/sodium alginate microcapsules and a preparation method thereof. In the method, chitosan/sodium alginate is used as a capsule material, sodium iron chlorophyllin is used as capsule content, and the sodium iron (II) chlorophyllin is microencapsulated by an emulsification-gel method. The preparation method comprises: dissolving sodium iron chlorophyllin in sodium alginate solution at a certain concentration, adding the prepared solution in vegetable oil containing Span-60, and stirring at high steep and emulsifying for 20 minutes; dripping acetic acid aqueous solution containing 2.0-percent chitosan and calcium chloride, continuously stirring for 30 minutes, standing for 2 hours and removing an oil phase; and washing the microcapsules with petroleum ether and isopropanol for three times respectively, performing suction-filtration, and drying at room temperature to obtain the sodium iron chlorophyllin-chitosan/sodium alginate microcapsules. The chitosan which is a natural polysaccharide with high biocompatibility and biodegradability and the sodium alginate serve as sustained and controlled release agent and targeting preparation, the sodium iron chlorophyllin is encapsulated in the center of the microcapsules to be protected from instability caused by change in a light or placing condition, a new formulation is provided in pharmacy, and the microcapsules are suitable to be further developed and used as iron-supplying health-care food and new medicinal preparation for treating iron-deficiency anemia, and have a bright application prospect.

Description

technical field [0001] The invention relates to a sodium iron chlorophyllin-chitosan / sodium alginate (CTS / ALG) microcapsule and a preparation method thereof, belonging to the field of preparation methods of medicinal and food pigments. Background technique [0002] Sodium iron chlorophyllin (including iron (II) chlorophyllin and iron (III) chlorophyllin) is easily soluble in water or dilute alcohol solution, but insoluble in oils and fats. After research and testing, the sodium iron chlorophyllinate solution is stable against indoor light, but its stability against outdoor natural light is not ideal. In addition to being a good food coloring, sodium iron chlorophyllin can also be used as an iron fortifier in medicine. Shengxuening tablets made of sodium iron chlorophyllin have been successfully used in the treatment of iron deficiency anemia. This is the only dosage form of iron chlorophyllin sodium salt in China. Utilizing the characteristics of microcapsules, the further...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61K9/50A61K31/409A61K47/36A61P7/06A23L1/09A23L1/275C09B47/04C09B67/02
Inventor 刘淑萍闫路省王丽芸
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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