Biodegradable extravascular stent and preparation method thereof

A technology for external stents and blood vessels, applied in medical science, surgery, etc., can solve the problems of promoting vascular intimal hyperplasia, and achieve the effects of uniform release, strength, and high drug loading

Inactive Publication Date: 2011-07-27
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1993, Violaris placed a PTFE restrictive stent outside the grafted vein and found that although the restrictive stent can inhibit the thickening of the grafted vein media, it also promotes the hyperplasia of the vascular intima and stenosis of the lumen.

Method used

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  • Biodegradable extravascular stent and preparation method thereof
  • Biodegradable extravascular stent and preparation method thereof
  • Biodegradable extravascular stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation method of degradable extravascular stent:

[0028] The first step: Synthesis of poly(ethylene carbonate) caprolactone copolymer: under the protection of argon, add comonomer ethylene carbonate (EC) and ε-caprolactone (CL) in toluene solvent for mixing, The molar concentration ratio of EC and CL is 1:6, the initial total concentration of EC and CL is 1.0mol / L, add catalyst tris(2,6-di-tert-butyl-4-methylphenoxy)lanthanum, catalyst three The initial concentration of (2,6-di-tert-butyl-4-methylphenoxy)lanthanum in toluene solvent was 1.0 × 10 -3 mol / L, copolymerization reaction at room temperature for 6 hours, adding ethanol solution of hydrogen chloride with a weight concentration of 5% as a terminator and precipitant, the volume ratio of ethanol solution of hydrogen chloride to the reaction system is 1:2, filter, and use the obtained precipitation Washed with ethanol and dried in vacuum to constant weight.

[0029] Step 2: Prepare the above polycaprolacton...

Embodiment 2

[0038] Preparation method of degradable extravascular stent:

[0039]The first step: Synthesis of poly(ethylene carbonate) caprolactone copolymer: under the protection of argon, add comonomer ethylene carbonate (EC) and ε-caprolactone (CL) in toluene solvent for mixing, The molar concentration ratio of EC and CL is 1:6, the initial total concentration of ethylene carbonate and ε-caprolactone is 1.0mol / L, and the catalyst tris(2,6-di-tert-butyl-4-methylbenzene oxy)lanthanum, the initial concentration of the catalyst was 1.0×10 -3 mol / L, copolymerization reaction at room temperature for 6 hours, adding ethanol solution of hydrogen chloride with a weight concentration of 5% as a terminator and precipitant, the volume ratio of ethanol solution of hydrogen chloride to the reaction system is 1:2, filter, and use the obtained precipitation Washed with ethanol and dried in vacuum to constant weight.

[0040] Step 2: Prepare the above polycaprolactone ethylene carbonate copolymer in...

Embodiment 3

[0049] Preparation method of degradable extravascular stent:

[0050] The first step: Synthesis of poly(ethylene carbonate) caprolactone copolymer: under the protection of argon, add comonomer ethylene carbonate (EC) and ε-caprolactone (CL) in toluene solvent for mixing, The molar concentration ratio of EC and CL is 1:6, the initial total concentration of ethylene carbonate and ε-caprolactone is 1.0mol / L, and the catalyst tris(2,6-di-tert-butyl-4-methylbenzene oxy)lanthanum, the initial concentration of the catalyst was 1.0×10 -3 mol / L, copolymerization reaction at room temperature for 6 hours, adding ethanol solution of hydrogen chloride with a weight concentration of 5% as a terminator and precipitant, the volume ratio of ethanol solution of hydrogen chloride to the reaction system is 1:2, filter, and use the obtained precipitation Washed with ethanol and dried in vacuum to constant weight.

[0051] Step 2: Prepare the above polycaprolactone ethylene carbonate copolymer i...

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Abstract

The invention relates to a biodegradable extravascular stent and a preparation method thereof. The biodegradable extravascular stent comprises a biodegradable material film and is characterized in that taxol is dispersed in the biodegradable material film. The invention also provides a preparation method of the biodegradable extravascular stent, which is characterized by comprising the following concrete steps of: preparing a polycaprolactone and ethylene carbonate copolymer solution; adding a taxol solution; stirring uniformly; carrying out electrostatic spinning; and standing at room temperature to enable a solvent to volatilize, thereby obtaining a polycaprolactone and ethylene carbonate copolymer film in which the taxol is dispersed. The biodegradable extravascular stent obtained by the invention has an external support effect on vein grafts, can prevent and treat excessive proliferation of the tunica intima of the vein through drugs, and can avoid the risk of thrombosis caused by a drug eluting stent.

Description

technical field [0001] The invention relates to a degradable extravascular stent and a preparation method thereof. Background technique [0002] Autologous vein graft arterial bypass surgery is one of the main treatments for vascular obstructive diseases such as atherosclerosis, and autologous vein is the most commonly used material for repairing defective blood vessels. However, after vein grafting, the incidence of hyperplasia of vein intima and lumen narrowing reaches 30%-50%. Although postoperative patients can take anti-platelet aggregation drugs and anticoagulant drugs to improve the short-term patency rate of grafted veins, the long-term blockage rate still reaches more than 50%. [0003] The research on extravascular stents has a long history and has achieved staged progress. Compared with intravascular stents, extravascular stents have the characteristics of not affecting hemodynamics, not directly contacting blood, not compressing vascular intima, and cheaper to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14A61L31/16
Inventor 符伟国张祥满刘震杰卢伟锋
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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