Adsorption method for preparing soybean lecithin

A technology for soybean lecithin and soybean lecithin, which is applied in the field of preparation of high-purity soybean lecithin, can solve the problems of harsh operation conditions of supercritical fluid extraction, large-scale promotion of equipment costs, unfavorable separation of phospholipids, etc., and can meet the requirements of large-scale industrial production. , The effect of high production efficiency and high recovery rate

Inactive Publication Date: 2011-08-10
NANJING TECH UNIV
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Problems solved by technology

Solvent extraction can improve the purity of lecithin, so it is generally used for the crude extraction of phospholipids, that is, the extraction of total phospholipids; supercritical fluid extraction mostly uses CO 2 It is used as an extractant, but its solubility to lecithin is poor, which is not conducive to the separation of various phospholipids, and the operating conditions of supercritical fluid extraction are harsh, and the huge cost of equipment is also a great defect for large-scale promotion; It is still quite difficult to separate phospholipid components with similar molecular weights, and it is necessary to develop a membrane with specific selective functions to obtain high-purity lecithin; column chromatography is indeed the most effective way to obtain high-purity lecithin at present. method, but there is also the problem of large amount of solvent and low production efficiency

Method used

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  • Adsorption method for preparing soybean lecithin

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Experimental program
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Effect test

Embodiment 1

[0022] Get soybean powder phospholipid 80g (phosphatidylcholine mass percentage content 45wt%), dissolve completely with 8L of absolute ethanol, add 240g activated alumina (100 mesh, Sinopharm Chemical Reagent Co., Ltd.), stir under 25 ℃ condition Adsorption for 120min. Filtrate to remove activated alumina. The filtrate was desolvated under reduced pressure at 0.015 MPa, then concentrated and dried in vacuum at 0.008 MPa and 55°C for 5 hours to obtain 36.2 g of solid lecithin product. The purity of phosphatidylcholine in the phospholipid sample determined by HPLC-UV method was 89.6%, and the recovery rate of phosphatidylcholine was 86.94%.

Embodiment 2

[0024] Get soybean lecithin 50g (phosphatidylcholine mass percentage content 47wt%), dissolve completely with 3.5L isopropanol, add 200g neutral alumina (300 mesh, Shanghai Ludu Chemical Reagent Factory), at 35 DEG C Stir and adsorb for 80min. Filter to remove the neutral alumina, and the filtrate is desolvated under reduced pressure at 0.02MPa, then concentrated and dried in vacuum at a pressure of 0.015MPa and a temperature of 45°C for 4.5h to obtain 23.57g of solid lecithin product. The purity of phosphatidylcholine in the phospholipid sample determined by HPLC-UV method was 85.3%, and the recovery rate of phosphatidylcholine was 85.83%.

Embodiment 3

[0026] Take 100g of soybean lecithin (phosphatidylcholine mass percentage 40wt%), dissolve it completely with 5L of methanol, add 300g of silica gel (200 mesh, Qingdao Ocean Chemical Co., Ltd.), and stir and adsorb at 30°C for 30min. Filtrate to remove the silica gel. The filtrate was first desolvated under reduced pressure at 0.025 MPa, and then concentrated and dried in vacuo at a pressure of 0.012 MPa and a temperature of 35° C. for 3.5 hours to obtain 46.70 g of solid lecithin product. The purity of phosphatidylcholine in the phospholipid sample determined by HPLC-UV method was 80.8%, and the recovery rate of phosphatidylcholine was 89.05%.

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Abstract

The invention relates to an adsorption method for preparing soybean lecithin. Granulesten is taken as a raw material, C1-C4 alcohol is taken as a solvent, an adsorbent is added, the mixture is stirred, adsorbed and filtered, filtrate is subjected to desolvation under reduced pressure and vacuum drying to form a soybean lecithin product with over 80 percent of phosphatidylcholine, and the yield is over 85 percent. Compared with the conventional preparation method, the direct adsorptive separation technology has the advantages of simple process, short production period, high product purity, low consumption of solvent, simple equipment, low investment cost and the like, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a method for preparing soybean lecithin by an adsorption method, in particular to a method for preparing high-purity soybean lecithin suitable for food, health products and pharmaceutical industries. Background technique [0002] Lecithin is a lipid substance containing phosphoric acid. It is an important substance that constitutes the biofilm of the human body. It plays a key role in maintaining the physiological activity of the biofilm and the normal metabolism of the body. On the other hand, its structure has lipophilicity. The non-polar end of fatty acyl group and the polar end of hydrophilic phosphate ester group and choline group are a kind of surfactant with superior performance, so it is widely used in the fields of food, health care products and medicine. At present, lecithin has attracted people's attention due to its excellent natural characteristics, especially in the research of liposomes and anticancer drug carrie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10
Inventor 管国锋郁丽薇杨操
Owner NANJING TECH UNIV
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