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Nanometer probe and application thereof in tumor diagnosis composition and photodynamic therapy

A nano-probe and photodynamic technology, applied in the direction of anti-tumor drugs, drug combinations, medical preparations of non-active ingredients, etc., can solve the problem of not fully reflecting the dynamic process of individual tumor patients, not being able to effectively distinguish cancer cells from normal cells, Can not fully predict the effect of tumor treatment and other issues, to achieve the effect of good biocompatibility and safety, not easy to leak, and simple preparation method

Inactive Publication Date: 2011-08-31
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main problems in the current clinical diagnosis and treatment of tumors are: the separation of diagnosis and treatment of tumors, the inability to fully reflect the entire clinical dynamic process of individual tumor patients during treatment, and the inability to fully predict the therapeutic effect of tumors; Inability to effectively distinguish cancer cells from normal cells, resulting in systemic toxicity and adverse reactions
The biggest disadvantage of MRI is the low sensitivity to signal detection, and generally only detects the content of paramagnetic components at the μmol level in tissues

Method used

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  • Nanometer probe and application thereof in tumor diagnosis composition and photodynamic therapy
  • Nanometer probe and application thereof in tumor diagnosis composition and photodynamic therapy
  • Nanometer probe and application thereof in tumor diagnosis composition and photodynamic therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] a) Weigh 2.51g (0.0093mol) FeCl 3 ·6H 2 O and 1.25g (0.0045mol) FeSO 4 ·7H 2 O was dissolved in 600ml of deionized water, and under the protection of nitrogen at room temperature, 24ml of ammonia water with a concentration of 1.5mol / l was added point by point to the above solution to obtain a black precipitate. Washing 5 times with deionized water by means of magnetic separation, dispersing the magnetic nanoparticles in 12 ml of 0.3 M sodium citrate solution and reacting for 30 minutes to obtain magnetic nanoparticles.

[0044] Or by pyrolysis method, weigh 0.706g (0.002mol) of iron acetylacetonate (Fe(acac) 3 ) was dissolved in 10ml of dibenzyl ether and 10ml of oleylamine and dehydrated at 110°C for 1 hour, quickly heated to 300°C for 2 hours, added 50ml of ethanol after cooling, added 0.015mol of sodium citrate solution and reacted for 30 minutes to obtain magnetic nanoparticles.

[0045] b) Dissolve 1ml of the magnetic nanoparticles prepared in step a) with a co...

Embodiment 2

[0063] a) Weigh 2.51g (0.0093mol) FeCl 3 ·6H 2 O and 1.25g (0.0045mol) FeSO 4 ·7H 2 O was dissolved in 600ml of deionized water, and under the protection of nitrogen at room temperature, 24ml of ammonia water with a concentration of 1.5mol / l was added point by point to the above solution to obtain a black precipitate. Washing 5 times with deionized water by means of magnetic separation, dispersing the magnetic nanoparticles in 12 ml of 0.3 M sodium citrate solution and reacting for 30 minutes to obtain magnetic nanoparticles.

[0064] Or by pyrolysis method, weigh 0.706g (0.002mol) of iron acetylacetonate (Fe(acac) 3 ) was dissolved in 10ml of dibenzyl ether and 10ml of oleylamine and dehydrated at 110°C for 1 hour, quickly heated to 300°C for 2 hours, added 50ml of ethanol after cooling, added 0.015mol of sodium citrate solution and reacted for 30 minutes to obtain magnetic nanoparticles.

[0065] b) Dissolve 1ml of magnetic nanoparticles with a concentration of 0.25mM in...

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Abstract

The invention provides a nanometer probe. First, a ferroferric oxide magnetic nanometer particle is synthesized by using a coprecipitation method or a high temperature decomposition method; and then the surface of the ferroferric oxide magnetic nanometer particle is modified so that the surface of the magnetic nanometer particle carries functional groups like a hydroxyl, an amino, a carboxyl, a sulfydryl or the like; and a photodynamic drug is coupled with the functional groups on the surface of the magnetic nanometer particle by using a covalent chemical reaction. The nanometer probe prepared by the invention is of spherical shape, has uniform granularity and has an average particle size of less than 50 nm, can be stably dispersed in an aqueous solution; and the preparation can generate a photodynamic effect while irradiated by light with proper wavelengths. The magnetic nanometer particle can be used for magnetically targeted drug transportation, nuclear magnetic resonance imaging and thermal therapy; photosensitizer drugs can be used for near infrared imaging and photodynamic therapy; and the invention is a novel nanometer probe integrated with magnetic target, thermal therapy and photodynamic therapy and provided with an imaging effect.

Description

technical field [0001] The invention belongs to the field of nano-probe preparation and biomedical application, in particular to a multifunctional nano-probe integrating tumor targeting, imaging and treatment. Background technique [0002] Tumor has become a common and frequently-occurring disease that seriously threatens human life. According to WHO statistics, a total of 37.1 million people suffer from malignant tumors in the world, about 8.7 million people develop new tumors every year, and the annual number of cancer deaths is about 6.9 million, accounting for 79.3% of the number of cases; One person was killed by cancer. There are 1.8 million cancer cases and 1.2 million deaths each year in my country, accounting for 15% of the total death toll in China. Cancer death has become the number one cause of death in my country's urban areas, and it is also the number one among the population aged 20-64 in my country. cause of death. [0003] The main problems in the current...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/48A61K41/00A61K31/409A61K49/00A61K49/06A61K49/18A61P35/00A61K47/52A61K47/69
Inventor 黄鹏崔大祥王贤松
Owner SHANGHAI JIAO TONG UNIV
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