Method for preparing fluorapatite crystal whisker in-situ reinforced porous tricalcium phosphate biological ceramics

Abstract

The invention relates to a method for preparing fluorapatite crystal whisker in-situ reinforced porous beta-tricalcium phosphate biological ceramics, and belongs to the technical field of the preparation of biological ceramics. The method is characterized by comprising the following steps of: weighing beta-tricalcium phosphate, bioglass and ammonium fluoride (or fluorine salts such as sodium fluoride and the like) serving as raw materials in a mass ratio of (65-85):(10-30):(0.25-1.5), and performing solid-phase reaction at a high temperature to prepare high-strength fluorapatite crystal whisker in-situ reinforced tricalcium phosphate porous biological ceramics. The method has the advantages that toughness is enhanced by introducing fluorapatite crystal whiskers and the strength of a substrate is enhanced, and the biological ceramics are mainly used for the field of the repair of bone tissue engineering at bearing positions or other positions.

Description

(1) Technical field:

[0001] The invention relates to the field of bioceramic bone tissue engineering scaffolds, in particular to a method for preparing porous calcium phosphate bioceramics reinforced in situ by fluoroapatite whiskers. (two) background technology:

[0002] As a bone graft material, porous calcium phosphate ceramics are widely used in bone tissue engineering because their basic components are similar to the inorganic components in bone matrix, and they have good biocompatibility and biodegradability. Providing a porous scaffold for the growth of new bone to repair bone defects has osteoconduction effect, but its main disadvantage is that the existence of pores reduces its mechanical properties, which affects the effect of repairing large-scale bone defects to a certain extent. The compressive strength of the calcium phosphate-based porous materials reported so far is 0.3-3.3 MPa, but it still cannot meet the requirements of clinical applications. Related resea...

Examples

Embodiment 1

[0020] Embodiment 1 A method for preparing porous tricalcium phosphate bioceramics in situ reinforced by fluoroapatite whiskers, which is composed of the following steps:

[0021] Mix β-tricalcium phosphate, bioglass, and ammonium fluoride uniformly in a mass ratio of 75:15:0.75, add deionized water, make the solid phase mass content 68%, and add a pH value of 9 The ammonium polyacrylate is used as a dispersant, ball milled, and formulated into a slurry, the ratio of the dispersant to the solid phase is 0.05-0.1ml / g, and the polyurethane foam with a pore size of 200-500um is soaked in the slurry, Take out and extrude excess slurry, repeat several times so that the slurry is evenly coated on the pore wall of the foam body, dry naturally in the air, place in a program-controlled furnace or a resistance furnace, and raise the temperature from room temperature at a heating rate of 1°C / min Pat glue at 600°C, and then sinter at 1300°C at 4°C / min for 3 hours to make a porous body.

...

Embodiment 2

[0026] Embodiment 2 A method for preparing porous tricalcium phosphate bioceramics in situ reinforced by fluoroapatite whiskers, which is composed of the following steps:

[0027] Mix β-tricalcium phosphate, bioglass, and sodium fluoride uniformly in a mass ratio of 80:18:0.75, add deionized water, make the solid phase mass content 68%, and add a pH value of 9 The ammonium polyacrylate is used as a dispersant, ball milled, and formulated into a slurry, the ratio of the dispersant to the solid phase is 0.05-0.1ml / g, and the polyurethane foam with a pore size of 200-500um is soaked in the slurry, Take out and extrude excess slurry, repeat several times so that the slurry is evenly coated on the pore wall of the foam body, dry naturally in the air, place in a program-controlled furnace or a resistance furnace, and raise the temperature from room temperature at a heating rate of 1°C / min Pat glue at 600°C, and then sinter at 1300°C at 4°C / min for 3 hours to make a porous body.

[...

(1) Technical field:

[0001] The invention relates to the field of bioceramic bone tissue engineering scaffolds, in particular to a method for preparing porous calcium phosphate bioceramics reinforced in situ by fluoroapatite whiskers. (two) background technology:

[0002] As a bone graft material, porous calcium phosphate ceramics are widely used in bone tissue engineering because their basic components are similar to the inorganic components in bone matrix, and they have good biocompatibility and biodegradability. Providing a porous scaffold for the growth of new bone to repair bone defects has osteoconduction effect, but its main disadvantage is that the existence of pores reduces its mechanical properties, which affects the effect of repairing large-scale bone defects to a certain extent. The compressive strength of the calcium phosphate-based porous materials reported so far is 0.3-3.3 MPa, but it still cannot meet the requirements of clinical applications. Related resea...

Examples

Embodiment 1

[0020] Embodiment 1 A method for preparing porous tricalcium phosphate bioceramics in situ reinforced by fluoroapatite whiskers, which is composed of the following steps:

[0021] Mix β-tricalcium phosphate, bioglass, and ammonium fluoride uniformly in a mass ratio of 75:15:0.75, add deionized water, make the solid phase mass content 68%, and add a pH value of 9 The ammonium polyacrylate is used as a dispersant, ball milled, and formulated into a slurry, the ratio of the dispersant to the solid phase is 0.05-0.1ml / g, and the polyurethane foam with a pore size of 200-500um is soaked in the slurry, Take out and extrude excess slurry, repeat several times so that the slurry is evenly coated on the pore wall of the foam body, dry naturally in the air, place in a program-controlled furnace or a resistance furnace, and raise the temperature from room temperature at a heating rate of 1°C / min Pat glue at 600°C, and then sinter at 1300°C at 4°C / min for 3 hours to make a porous body.

...

Embodiment 2

[0026] Embodiment 2 A method for preparing porous tricalcium phosphate bioceramics in situ reinforced by fluoroapatite whiskers, which is composed of the following steps:

[0027] Mix β-tricalcium phosphate, bioglass, and sodium fluoride uniformly in a mass ratio of 80:18:0.75, add deionized water, make the solid phase mass content 68%, and add a pH value of 9 The ammonium polyacrylate is used as a dispersant, ball milled, and formulated into a slurry, the ratio of the dispersant to the solid phase is 0.05-0.1ml / g, and the polyurethane foam with a pore size of 200-500um is soaked in the slurry, Take out and extrude excess slurry, repeat several times so that the slurry is evenly coated on the pore wall of the foam body, dry naturally in the air, place in a program-controlled furnace or a resistance furnace, and raise the temperature from room temperature at a heating rate of 1°C / min Pat glue at 600°C, and then sinter at 1300°C at 4°C / min for 3 hours to make a porous body.

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