Bionic cartilage material and preparation process thereof

A preparation process and cartilage technology, applied in the field of biomedical materials or biocomposite materials, can solve the problems of no biological activity, poor binding performance, affecting cartilage fixation and repair function, etc., achieving good buffering effect, reducing friction and wear, The effect of resolving conflicts between mechanical properties and lubricating properties

Inactive Publication Date: 2011-10-05
CHINA UNIV OF MINING & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyvinyl alcohol (PVA) hydrogel has a smooth surface and no biological activity. When it is implanted into the joint as a cartilage prosthesis, it has poor bonding performance with the substrate, which affects the fixation and repair function of cartilage. Hydroxyapatite composite can solve this problem

Method used

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  • Bionic cartilage material and preparation process thereof
  • Bionic cartilage material and preparation process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1, shred silk to a length less than 2mm, and put it in a sealed bag for subsequent use; weigh polyvinyl alcohol 11%, shred silk 0.1% to a length less than 2mm, nano-hydroxyapatite 4%, and 84.9% deionized water, put in a container and stir to mix evenly. After the mixed liquid in the container is still, mark the initial liquid level height of the mixture on the container, and then place the container at a temperature of 18°C ​​for 12 hours to make the liquid in the mixture The polyvinyl alcohol is fully swollen; then the container is placed in a constant temperature water bath with a temperature of 95°C, and stirred while heating until the polyvinyl alcohol is completely dissolved; the container is taken out of the constant temperature water bath, due to the temperature in the evaporation process Part of the water is volatilized. At this time, add deionized water to the container until the liquid level reaches the height of the initial liquid level, and stir to...

Embodiment 2

[0018] Embodiment 2: Shred silk to a length less than 2mm, and put it in a sealed bag for subsequent use; weigh polyvinyl alcohol 17%, shredded silk 0.6%, nano-hydroxyapatite 0.1%, and deionized water 82.3% by mass percentage %, placed in the container and stirred evenly; after the mixed liquid in the container is still, mark the initial liquid level height of the mixture on the container, and then place the container at a temperature of 18°C ​​for 12 hours to make the polyvinyl alcohol in the mixture Fully swell; place the container in a constant temperature water bath at a temperature of 95°C, heat and stir until the polyvinyl alcohol is completely dissolved; take the container out of the constant temperature water bath, and add deionized water to the container until the liquid level reaches the initial liquid level , stir and mix evenly, oscillate ultrasonically for 2 hours, and discharge the air bubbles in the mixture to obtain a polyvinyl alcohol mixture hydrogel; pour the...

Embodiment 3

[0019] Embodiment 3: Shred silk to a length less than 2mm, and put it in a sealed bag for subsequent use; weigh 15.0% polyvinyl alcohol, 1% shredded silk, 2% nano-hydroxyapatite, and 82% deionized water by mass percentage %, placed in the container and stirred evenly; after the mixed liquid in the container is still, mark the initial liquid level height of the mixture on the container, and then place the container at a temperature of 18°C ​​for 12 hours to make the polyvinyl alcohol in the mixture Fully swell; place the container in a constant temperature water bath at 95°C, heat and stir until the polyvinyl alcohol is completely dissolved; take the container out of the constant temperature water bath, add deionized water to the container until the liquid level reaches the initial liquid level, Stir and mix evenly, ultrasonically oscillate for 2 hours, and discharge the air bubbles in the mixture to obtain a polyvinyl alcohol mixture hydrogel; pour the polyvinyl alcohol mixture...

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Abstract

The invention discloses a bionic cartilage material and a preparation process thereof. A mixed material of polyvinyl alcohol, nano hydroxyapatite, silk and deionized water is adopted. The preparation process comprises the following steps of: weighing the polyvinyl alcohol, the nano hydroxyapatite, the silk and the deionized water in percentage by mass, putting the mixed material into a container, and stirring and mixing the mixed material uniformly; placing the container for a certain time at the temperature of 18 DEG C so that the polyvinyl alcohol in the mixture is fully swollen; putting the container in a thermostatic water bath of 95 DEG C, and heating and stirring till the polyvinyl alcohol is fully dissolved; taking the container out of the thermostatic water bath, and stirring and mixing uniformly to obtain polyvinyl alcohol mixture hydrogel; and pouring the obtained polyvinyl alcohol mixture hydrogel into a die, freezing the die in a low-temperature freezer of 20 DEG C below zero, taking out the frozen hydrogel, unfreezing the frozen hydrogel, freezing the unfrozen hydrogel in the low-temperature freezer, unfreezing the frozen hydrogel, and repeating the process for multiple times to obtain the bionic cartilage material. The process is simple; and the material has good bonding property and good mechanical property similar to that of natural cartilage.

Description

technical field [0001] The invention relates to a bionic cartilage material and a preparation process thereof, belonging to the technical field of biomedical materials or biocomposite materials, in particular to a bionic cartilage implant material suitable for low friction and high cushioning and a preparation process thereof. Background technique [0002] Joints are biological friction pairs that bear the greatest load in the human body, and cartilage is the soft tissue located between bones. Cartilage under physiological load is an excellent stress buffer material, which can transmit load evenly, expand the joint load-bearing surface, reduce contact stress, and buffer shock, and the smooth cartilage surface can minimize friction and wear when the articular surface moves relative to each other limit. Articular cartilage is a highly hydrated biological tissue covering one end of joint bones, mainly composed of extracellular matrix and chondrocytes, without blood vessels, ly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/16A61L27/36
Inventor 张德坤葛世荣戴祖明
Owner CHINA UNIV OF MINING & TECH
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