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Preparation method of antibacterial dressing for promoting wound healing

A wound dressing, bacterial cellulose technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of easy degradation, unable to control drug release, etc., and achieve the effect of strong antibacterial ability

Inactive Publication Date: 2011-10-12
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibacterial drug dressings currently available on the market cannot effectively control the release of drugs during use
However, hyaluronic acid dressings with the effect of promoting wound healing are mostly incorporated into dressings in the form of adsorption, and free hyaluronic acid has the problem of easy degradation during use, storage and use (the characteristics of the cross-linked hyaluronic acid film are related to biological phases). A Preliminary Study of Capacitance, Chinese Journal of Biochemical Medicine, 2006, 27, 25-28.)

Method used

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  • Preparation method of antibacterial dressing for promoting wound healing
  • Preparation method of antibacterial dressing for promoting wound healing

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preparation example Construction

[0015] The preparation method of the antibacterial and healing-promoting wound dressing of the present invention comprises the following steps:

[0016] In the first step, the wet flocculent bacterial cellulose is rinsed and then added to an alkali solution for heat treatment, then neutralized with an acid solution, and then washed with deionized water until neutral; the bacterial cellulose is prepared by a dynamic fermentation method, and the alkali The solution is a mixture of one or more of sodium hydroxide, potassium hydroxide and sodium carbonate, and the concentration of the alkali solution is 1%-4%.

[0017] In the second step, the product obtained in the first step is immersed in a silver salt solution, and then the solid is separated by filtration, and after washing with deionized water, a reducing agent is added and reacted under stirring conditions, and then the obtained product is rinsed and removed. Moisture removal; the silver salt is silver nitrate or silver 2-e...

Embodiment 1

[0024] The first step is to pretreat the wet flocculent bacterial cellulose, that is, add 1% sodium hydroxide alkali solution after rinsing and keep warm at 90°C for 3 hours, then neutralize with acetic acid solution, and then wash with deionized water until neutral;

[0025] In the second step, the product obtained in the first step is placed in 0.005mol / L AgNO3 silver salt solution and immersed, then filtered and separated to obtain a solid, then washed with deionized water, and then added ascorbic acid to reduce silver ions under mechanical stirring conditions, React at room temperature for 3 hours, rinse the product and remove 80% of the water in the system;

[0026] In the third step, soak the product obtained in the second step with 3% hyaluronic acid, remove 80% of the water in the system, add 2% carbodiimide cross-linking agent, and react at 30°C for 24 hours.

[0027] In the fourth step, the product of the third step is separated by filtration, washed three times with...

Embodiment 2

[0031] The first step is to pretreat the wet flocculent bacterial cellulose, that is, add 1% potassium hydroxide alkali solution at 90°C for 3 hours after rinsing, then neutralize with acetic acid solution, and then wash with deionized water until neutral;

[0032] In the second step, the product obtained in the first step is immersed in 0.008mol / L AgNO3 silver salt solution, then filtered to separate the solid, and after washing with deionized water, potassium borocyanide is added under mechanical stirring to reduce Silver ions, react at room temperature for 6 hours, rinse the product and remove 70% of the water in the system;

[0033] In the third step, after soaking the product obtained in the second step with 2.5% hyaluronic acid, remove 70% of the water in the system, and add 2% 1-(3-dimethylaminopropyl)-3-ethyl Based on carbodiimide crosslinking agent, react at 30°C for 24h.

[0034] In the fourth step, the product of the third step is separated by filtration, washed th...

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Abstract

The invention discloses a preparation method of an antibacterial dressing for promoting wound healing, comprising the following steps of: carrying out pretreatment on flocculent bacterial cellulose obtained by utilizing a dynamic zymotechnics, and then uniformly implanting nano silver on the bacterial cellulose surface by utilizing an in-situ chemical reduction method to obtain a bacterial cellulose nano silver composite material; and placing the bacterial cellulose nano silver composite material into a hyaluronic acid solution for dipping, dehydrating the bacterial cellulose for adsorbing hyaluronic acid, and carrying out a coupling reaction by utilizing carbodiimide to form a bacterial cellulose / hyaluronic acid-loaded nano silver composite material. The composite material has the effects of a controlled release bacteriacide for controlling wound infection and interaction between cells and a substrate and promoting wound healing. In the invention, a composite film is prepared through bacterial cellulose / hyaluronic acid-loaded nano silver, high flexibility of a bacterial cellulose substrate and favorable skin adhesiveness are exerted, and the antibacterial dressing has the antibacterial effect of promoting wound healing and can be used for preparing multipurpose drug wound dressings for accelerating wound repairing.

Description

technical field [0001] The invention belongs to dressing function construction technology in wound treatment, and in particular relates to a preparation method of an antibacterial and healing-promoting wound dressing. Background technique [0002] Wound or postoperative dressing is very important in burn plastic surgery, and sometimes the success or failure of surgery is directly related to wound infection and healing time to a large extent. For this reason, the use of wound dressings with antibacterial and healing-promoting functions is of great significance to the plastic treatment of burns. [0003] Commodities such as the use of biosynthesized bacterial cellulose as dressings for the treatment of skin injuries, bedsores, and ulcers, or as pellicles for tissues and organs, have appeared. But at present, a single bacterial cellulose material is used as a dressing, which only has the functions of covering the wound, absorbing exudate during inflammation, and keeping the wo...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/22A61L15/42
Inventor 汪信孙东平何浩明杨加志
Owner NANJING UNIV OF SCI & TECH
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