Capsule for treating ulcerative colitis

A technology for ulcerative colitis and capsules, which is applied in the field of traditional Chinese medicine preparations of Coptis chinensis and Muxiang, which can solve the problems of non-targeted release, low content of active ingredients, and large dosage

Active Publication Date: 2011-11-02
SOUTHERN MEDICAL UNIVERSITY
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are many shortcomings in the water pan pills that Coptidis Rhizoma and Rhizoma Rhizoma directly mix and make, the impurity content is high in one preparation, the active ingredient content is low, and the dosa

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Capsule for treating ulcerative colitis
  • Capsule for treating ulcerative colitis
  • Capsule for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0065] Example 1 (preparation of coptis extract)

[0066] 1. Preparation of Coptidis Rhizoma Extract

[0067] (1) Take Yuhuanglian medical material and grind it into 3 kg of coarse powder, add 12 times of ethanol with a volume concentration of 80% (V / V) to extract twice, each extraction for 1.5 hours, and recover ethanol under reduced pressure to obtain a concentrated solution;

[0068] (2) Use hydrochloric acid to adjust the pH value of the concentrated solution to 2.0, then add sodium chloride until the sodium chloride content is 10% (W / V), let stand for 24 hours, and filter with suction to obtain the filtrate and precipitate; take the precipitate Rinse with water to obtain a washing solution and a washing precipitate; then take the washing precipitate and dry it under reduced pressure at 80°C to a constant weight to obtain Coptis Rhizoma Alkaloid Extract I;

[0069] (3) The filtrate and washing liquid of merging step (2), the pH is adjusted to 5.0 with sodium hydroxide tes...

example 2

[0083] 1. Prescription:

[0084] Muxiang volatile oil instant pellets: Muxiang volatile oil 1g, β-CD 8g, 5% starch microcrystalline cellulose 16g.

[0085] Coptidis alkaloids colon-targeted pellets: ball core: Coptidis extract 24g of example 1, microcrystalline cellulose 24g of 5% starch; coating material: acrylic resin (Utech) L100-55 0.36g, acrylic resin ( Eudragit) S100 1.08g, diethyl phthalate 0.043g, talcum powder 0.28g.

[0086] 2. Preparation method

[0087] (1) Muxiang volatile oil instant pellets

[0088]Add the volatile oil of Akiras volatile oil to an equal volume of absolute ethanol to make a mixed solution of Akiras volatile oil-ethanol for use; weigh β-CD in proportion and dissolve it in 20 times (W / V) distilled water, and place it in a constant temperature water bath at 50°C Stir on the top (keep the speed at 100rpm), and at the same time add the volatile oil-ethanol mixed solution dropwise at a rate of 2ml / min, stir at a constant temperature for 3 hours, coo...

example 3

[0095] 1. Prescription:

[0096] Muxiang volatile oil instant pellets: Muxiang volatile oil 3g, β-CD 24g, 5% starch microcrystalline cellulose 48g.

[0097] Coptidis colon-targeted pellets: ball core: Coptidis extract 72g of example 1, microcrystalline cellulose 216g of 5% starch; coating material: acrylic resin (Utech) L100-55 3.6g, acrylic resin (Utech) Qi) S100 10.8g, diethyl phthalate 0.43g, talcum powder 2.8g

[0098] 2. Preparation method

[0099] (1) Muxiang volatile oil instant pellets

[0100] Add the volatile oil of Akiras volatile oil to an equal volume of absolute ethanol to make a mixed solution of Akiras volatile oil-ethanol for use; weigh β-CD in proportion and dissolve it in 20 times (W / V) distilled water, and place it in a constant temperature water bath at 50°C Stir on the top (keep the rotation speed at 100rpm), and at the same time add the volatile oil-ethanol mixed solution dropwise at a rate of 2ml / min, stir at a constant temperature for 3 hours, cool ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a traditional Chinese medicine composition, and particularly relates to a capsule for treating ulcerative colitis. The content of the capsule is composed of the following ingredients in parts by weight: 24-56 parts of Radix Aucklandiae instant micropills and 49-105 parts of Rhizoma Coptidis colon-targeted micropills, wherein the Radix Aucklandiae instant micropills are composed of the following ingredients in parts by weight: 1 part of a Radix Aucklandiae volatile oil, 8-15 parts of beta-CD (cyclodextrin) and 16-40 parts of a shaping agent; and the Rhizoma Coptidis colon-targeted micropills are composed of the following ingredients in parts by weight: 24 parts of a Rhizoma Coptidis extract, 24-72 parts of a pill core excipient, 0.36-1.2 parts of acrylic resin L100-55, 1.08-3.6 parts of acrylic resin S100, 0.043-0.144 parts of diethyl phthalate and 0.28-0.96 parts of talcum powder. The capsule provided by the invention can separately release two different functional ingredients in the stomach and colon, and has the advantage of high drug availability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to traditional Chinese medicine compositions, in particular to traditional Chinese medicine preparations of Coptidis rhizome and woody incense. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is a multifactorial intestinal disease, with non-specific inflammatory lesions in the submucosa of the rectum and colon as the main symptom, mainly involving the rectum and sigmoid colon, and may also invade other parts or all colon and terminal ileum. The clinical manifestations are mainly abdominal pain, diarrhea, pus and blood in the stool or tenesmus and indigestion. Western medicine for the treatment of ulcerative colitis drugs are mainly aminosalicylic acid, adrenal cortex hormones, antibacterial drugs, immunosuppressive drugs and so on. These drugs can control the ulcer inflammation in patients, but the adverse reactions are many and serious, and t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/718A61K9/48A61P1/04
Inventor 谭晓梅罗佳波陈飞龙张文新
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap