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Capsule for treating ulcerative colitis

A technology for ulcerative colitis and capsules, which is applied in the field of traditional Chinese medicine preparations of Coptis chinensis and Muxiang, which can solve the problems of non-targeted release, low content of active ingredients, and large dosage

Active Publication Date: 2011-11-02
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are many shortcomings in the water pan pills that Coptidis Rhizoma and Rhizoma Rhizoma directly mix and make, the impurity content is high in one preparation, the active ingredient content is low, and the dosage is large; Part of it is absorbed or metabolized after passing through the upper gastrointestinal tract, and only a small amount reaches the colonic lesion, so the drug effect cannot be exerted to the greatest extent

Method used

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  • Capsule for treating ulcerative colitis
  • Capsule for treating ulcerative colitis
  • Capsule for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0065] Example 1 (preparation of coptis extract)

[0066] 1. Preparation of Coptidis Rhizoma Extract

[0067] (1) Take Yuhuanglian medical material and grind it into 3 kg of coarse powder, add 12 times of ethanol with a volume concentration of 80% (V / V) to extract twice, each extraction for 1.5 hours, and recover ethanol under reduced pressure to obtain a concentrated solution;

[0068] (2) Use hydrochloric acid to adjust the pH value of the concentrated solution to 2.0, then add sodium chloride until the sodium chloride content is 10% (W / V), let stand for 24 hours, and filter with suction to obtain the filtrate and precipitate; take the precipitate Rinse with water to obtain a washing solution and a washing precipitate; then take the washing precipitate and dry it under reduced pressure at 80°C to a constant weight to obtain Coptis Rhizoma Alkaloid Extract I;

[0069] (3) The filtrate and washing liquid of merging step (2), the pH is adjusted to 5.0 with sodium hydroxide tes...

example 2

[0083] 1. Prescription:

[0084] Muxiang volatile oil instant pellets: Muxiang volatile oil 1g, β-CD 8g, 5% starch microcrystalline cellulose 16g.

[0085] Coptidis alkaloids colon-targeted pellets: ball core: Coptidis extract 24g of example 1, microcrystalline cellulose 24g of 5% starch; coating material: acrylic resin (Utech) L100-55 0.36g, acrylic resin ( Eudragit) S100 1.08g, diethyl phthalate 0.043g, talcum powder 0.28g.

[0086] 2. Preparation method

[0087] (1) Muxiang volatile oil instant pellets

[0088]Add the volatile oil of Akiras volatile oil to an equal volume of absolute ethanol to make a mixed solution of Akiras volatile oil-ethanol for use; weigh β-CD in proportion and dissolve it in 20 times (W / V) distilled water, and place it in a constant temperature water bath at 50°C Stir on the top (keep the speed at 100rpm), and at the same time add the volatile oil-ethanol mixed solution dropwise at a rate of 2ml / min, stir at a constant temperature for 3 hours, coo...

example 3

[0095] 1. Prescription:

[0096] Muxiang volatile oil instant pellets: Muxiang volatile oil 3g, β-CD 24g, 5% starch microcrystalline cellulose 48g.

[0097] Coptidis colon-targeted pellets: ball core: Coptidis extract 72g of example 1, microcrystalline cellulose 216g of 5% starch; coating material: acrylic resin (Utech) L100-55 3.6g, acrylic resin (Utech) Qi) S100 10.8g, diethyl phthalate 0.43g, talcum powder 2.8g

[0098] 2. Preparation method

[0099] (1) Muxiang volatile oil instant pellets

[0100] Add the volatile oil of Akiras volatile oil to an equal volume of absolute ethanol to make a mixed solution of Akiras volatile oil-ethanol for use; weigh β-CD in proportion and dissolve it in 20 times (W / V) distilled water, and place it in a constant temperature water bath at 50°C Stir on the top (keep the rotation speed at 100rpm), and at the same time add the volatile oil-ethanol mixed solution dropwise at a rate of 2ml / min, stir at a constant temperature for 3 hours, cool ...

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Abstract

The invention relates to a traditional Chinese medicine composition, and particularly relates to a capsule for treating ulcerative colitis. The content of the capsule is composed of the following ingredients in parts by weight: 24-56 parts of Radix Aucklandiae instant micropills and 49-105 parts of Rhizoma Coptidis colon-targeted micropills, wherein the Radix Aucklandiae instant micropills are composed of the following ingredients in parts by weight: 1 part of a Radix Aucklandiae volatile oil, 8-15 parts of beta-CD (cyclodextrin) and 16-40 parts of a shaping agent; and the Rhizoma Coptidis colon-targeted micropills are composed of the following ingredients in parts by weight: 24 parts of a Rhizoma Coptidis extract, 24-72 parts of a pill core excipient, 0.36-1.2 parts of acrylic resin L100-55, 1.08-3.6 parts of acrylic resin S100, 0.043-0.144 parts of diethyl phthalate and 0.28-0.96 parts of talcum powder. The capsule provided by the invention can separately release two different functional ingredients in the stomach and colon, and has the advantage of high drug availability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to traditional Chinese medicine compositions, in particular to traditional Chinese medicine preparations of Coptidis rhizome and woody incense. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is a multifactorial intestinal disease, with non-specific inflammatory lesions in the submucosa of the rectum and colon as the main symptom, mainly involving the rectum and sigmoid colon, and may also invade other parts or all colon and terminal ileum. The clinical manifestations are mainly abdominal pain, diarrhea, pus and blood in the stool or tenesmus and indigestion. Western medicine for the treatment of ulcerative colitis drugs are mainly aminosalicylic acid, adrenal cortex hormones, antibacterial drugs, immunosuppressive drugs and so on. These drugs can control the ulcer inflammation in patients, but the adverse reactions are many and serious, and t...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/48A61P1/04
Inventor 谭晓梅罗佳波陈飞龙张文新
Owner SOUTHERN MEDICAL UNIVERSITY
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