Use of clove oil, eugenol and derivatives thereof in the preparation of medicines for histamine H3 receptor antagonists or inverse agonists

A technology of inverse agonists and receptor antagonists, applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of poor penetration of the central nervous system and unfavorable treatment of central nervous system diseases, and achieve clear drug effects, Quality Controlled Effects
CN102258577AInactive Publication Date: 2011-11-30CHENGDU MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHENGDU MEDICAL COLLEGE
Publication Date
2011-11-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides the application of clove oil, eugenol and derivatives thereof in the preparation of antagonists or inverse agonists of histamine H3 receptors, and also provides a method of using clove oil, eugenol or eugenol derivatives as The main active ingredient, together with other active ingredients, forms a new H3 receptor antagonist or inverse agonist drug, which can be used to prevent and treat senile dementia and depression. The H3 receptor antagonist or inverse agonist medicine provided by the invention has clear efficacy, controllable quality and safety, and provides a new choice for clinical practice.
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Description

technical field

[0001] The invention relates to the new application of clove oil, eugenol and derivatives thereof, in particular to the application in the preparation of medicaments of histamine H3 receptor antagonist or inverse agonist. Background technique

[0002] Histamine is produced by the decarboxylation of histidine by decarboxylase, and is a neurotransmitter with a wide range of physiological effects in the body. It has been found that histamine receptors consist of several different subtypes, namely H1, H2, H3 and H4 receptors. Both histamine H1 and H2 receptors are postsynaptic receptors, while histamine H3 receptor is a presynaptic autoreceptor widely distributed in the central nervous system and peripheral nervous system, in the central nervous system, the receptor The body not only participates in the regulation of the release, synthesis and metabolism of histamine in the brain, but also participates in the regulation of various neurotransmitters such as 5-hyd...

Claims

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