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A kind of preparation method of cat bean levodopa

A technology of levodopa and cat bean, which is applied in the field of preparation of cat bean levodopa, can solve the problems of unsatisfactory cat bean separation effect, long technological process, difficult filtration and the like, and achieves easy continuous production operation, short technological process, The effect of high separation efficiency

Inactive Publication Date: 2011-12-07
南宁市一锋生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to overcome the small processing capacity of cat beans in the prior art, the difficulty in filtration caused by the large amount of precipitation in the impurity removal and purification process, the long process flow, the difficulty of continuous operation, the unsatisfactory separation effect of cat beans, and the difficulty in industrial production Technical problem, provide a kind of preparation method of cat bean levodopa

Method used

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  • A kind of preparation method of cat bean levodopa

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Embodiment 1

[0034]Put 5 parts by weight of the raw material cat beans that have been removed and coarsely crushed into a 316 stainless steel reaction tank, add deionized water in a ratio of 1:3 parts by weight of raw materials and water, and add acrylic acid to adjust the pH value to 4, extract three times at room temperature , the time is 9h, and the extracts are combined. Then the extract is introduced into a stainless steel reaction tank for concentration under reduced pressure, the temperature is controlled to be ≤60°C, the vacuum degree is ≥0.08MPa, and concentrated into an extract of 8 degrees Baume. Then the concentrated extract is added in a stainless steel reaction kettle, ethanol with 180 times the weight portion of raw cat beans, 0.132 weight portion of acrylic acid, and 40 weight portions of inorganic salt ammonium sulfate are added, stirred evenly, and left to stand for 1.5h to form two phases, Obtain the upper phase extract, add 4 parts by weight (5:1, v / v) of ethyl acetate-...

Embodiment 2

[0037] Add 5 parts by weight of cat beans that have been removed and coarsely crushed into an aluminum alloy reaction tank, add deionized water in a ratio of 1:3 parts by weight of raw materials and water, and add acrylic acid to adjust the pH value to 4, extract three times at room temperature , the time is 8h, and the extracts are combined. Then the extract is introduced into an enamel reaction kettle for concentration under reduced pressure, the temperature is controlled to be ≤60°C, the vacuum degree is ≥0.08MPa, and concentrated into an extract of 7.8 degrees Baume. Then put the concentrated extract into the enamel reaction kettle, add 200 parts by weight of ethanol of raw cat beans, 0.113 parts by weight of methacrylic acid, and add 40 parts by weight of inorganic salt ammonium sulfate, stir evenly, stand for 1h to form two phases, and obtain For the upper phase extract, add 4 parts by weight (5:1, v / v) of the two-phase extractant ethyl acetate-petroleum ether that is in...

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Abstract

The invention discloses a preparation method of cat bean levodopa. In the method, cat bean is used as a raw material, and an acid aqueous solution is used as an extraction solvent. In the water phase system, the average concentration in the solution reaches the distribution equilibrium of 20-40%, and then extracts with an extractant that is incompatible with the two water phases to remove impurities respectively, and the remaining part is decolorized, crystallized and dried to obtain a mass fraction of 99.9% Levodopa products. The invention has the advantages of reduced process, no pollutant discharge, high levodopa product yield and purity, less solvent consumption, low cost and easy industrial production, and the obtained product can be used as a raw material medicine.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a preparation method of cat bean levodopa. Background technique [0002] Levodopa (3,4-Dihydrox ylphenylalanine, L-Dopa) belongs to phenylalanine compounds and is currently the most commonly used and effective treatment for primary parkinsonism and non-pharmaceutical parkinsonism It is one of the main active ingredients of Maodou and Lidou. The levodopa content of cat beans is 5.22-9.94%. After retrieval, the extraction and purification method of levodopa in cat bean is extracted as follows [0003] Chinese patent application No. 89101938.3, a method for producing levodopa with cat beans or Li beans. The technical scheme of the method is: soak the raw cat beans or Li beans with a special solvent (distilled water or ion-exchanged water plus 0.1-05% acetic acid and a small amount of antioxidants, etc.), grind them into a slurry, and then purify Treatment, concentration under red...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/36C07C227/40
Inventor 罗亚东关健敏
Owner 南宁市一锋生物科技有限公司
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