Method for preparing ibuprofen with large crystal form
A technology of crystal form and seed crystal, which is applied in the field of large crystal form preparation of ibuprofen, can solve problems such as no method for preparing large particle size crystal form, and achieve the effect of simple processing method, good fluidity and uniform particles
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[0011] In a 2000L stainless steel crystallization kettle, add 400kg of ibuprofen, add 800kg of 65% ethanol, heat to 65℃, stir to dissolve, clarify, filter, slowly lower the temperature to 38℃, and put 8kg of ibuprofen seed crystal with a particle size of 60-90μm , Stir well, keep it warm for 40 minutes, then under slow stirring, cool down every 30 minutes, each time the temperature is 1-2℃, after cooling to 30℃, fully open the ice salt water in the jacket of the crystallization kettle, cooling to 5℃ Following centrifugal filtration and drying at 60-65°C, a large crystalline ibuprofen product with a crystal particle size of 250-450 μm and an intermediate particle size of about 300 μm is obtained.
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