Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, antipyretics, etc., can solve the problems of affecting the absorption and utilization of active ingredients of drugs, slow release of active ingredients, and long healing period, so as to achieve improved compliance, drug The effect of stable active components and high bioavailability

Active Publication Date: 2012-05-02
JINHE TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the preparation methods of ruyizhenbao medicines all adopt the simple physical treatment of pulverizing and mixing the raw materials. Although the biological activity of the original medicine is retained, it is easy to cause dissolution, slow disintegration, and slow release of active ingredients. Affect the absorption and utilization of the active ingredients of the drug, resulting in slow onset and long healing period

Method used

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  • Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof
  • Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof
  • Traditional Tibetan medicine Ruyizhenbao composite preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0040] Experimental example one, the analgesic effect of pharmaceutical composition preparation of the present invention (prepared in embodiment 1)

[0041] 1 Test material

[0042] 1.1 Test animals

[0043] Kunming mice, male, 19-22g, Shandong Provincial Natural Medicine Engineering Technology Research Center Experimental Animal Center, certificate number: SYXK (Lu) 20030020.

[0044] 1.2 Experimental Drugs and Reagents

[0045] Test drug: Ruyi Zhenbao Pills, specification 0.5g / pill, batch number: 20100918, provided by Qinghai Jinhe Tibetan Medicine Co., Ltd. Capsule preparation of the pharmaceutical composition of the present invention, batch number: 20110110, provided by Shandong Arula Pharmaceutical Research and Development Co., Ltd.

[0046] Positive control drug: indomethacin, specification 25mg / tablet, batch number: A100802, commercially available.

[0047] Reagents: Acetic acid, Shandong Provincial Research Institute of Chemical Industry, batch number 980610; CMC-N...

experiment example 2

[0064] Experimental example two, pharmaceutical composition preparation of the present invention (prepared in embodiment 1) anti-gout effect

[0065] 1 Test material

[0066] 1.1 Test animals

[0067] SD rats, male, weighing 190-240g. Provided by the Experimental Animal Center of Shandong University of Traditional Chinese Medicine, certificate number: SCXK (Lu) 20050015.

[0068] 1.2 Experimental Drugs and Reagents

[0069] Test drug: capsule preparation of the pharmaceutical composition of the present invention, batch number: 20110110, provided by Shandong Arula Pharmaceutical Research and Development Co., Ltd.

[0070] Positive control drug: indomethacin, specification 25mg / tablet, batch number: A100802, commercially available.

[0071] Reagents: uric acid, purchased from Sigma Company, batch number: U2625; Tween 80, Shandong Provincial Institute of Chemistry, batch number: 080612; normal saline, Shandong Qidu Pharmaceutical Co., Ltd., batch number: 3B10102305; chloral h...

Embodiment 1

[0098] The specific embodiment embodiment 1 pharmaceutical composition capsule of the present invention

[0099] Raw material composition:

[0100]

[0101] (1) Extraction and inclusion of volatile oil: Take 100g of agarwood, 40g of clove, 40g of nutmeg, 40g of cardamom, 30g of grass fruit, 40g of parsley, 80g of sandalwood, 40g of black cumin, 330g of balsamic Longan longan 30g, galangal 80g, cinnamon 50g, woody fragrance 80g, Tibetan woody fragrance 80g, add 6 times the weight of water, use steam distillation to extract volatile oil, extract 4h, collect volatile oil, get 25ml of volatile oil, filter the liquid medicine, get medicine Liquid A and medicinal dregs A, medicinal liquid A concentrated to liquid extract A with a relative density of 1.12 under the condition of 60°C; volatile oil was clathrated with β-cyclodextrin, and the process was as follows: take volatile oil, according to volatile oil: β-cyclodextrin=1ml : 4g ratio, under stirring conditions, add the volati...

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Abstract

The invention discloses a Ruyizhenbao medicine composite, which is prepared by adopting the following steps of essential oil extraction and inclusion, ethanol extraction, water extraction, fluid extract drying, medicinal material fine powder crushing, expensive and fine medicine fine powder preparation and the like. Pharmaceutically conventional auxiliary materials are added according to a conventional process to be prepared into clinically acceptable dosage forms such as: powders, capsules, tablets, oral liquid, condensed pills, granular formulations, pills, pellets and slow release preparations. The invention is characterized in that the Ruyizhenbao composite is prepared by taking phytochemical components as the material base and the pharmacodynamics activity as the guidance by adoptinga modern extraction preparation method. The medicinal preparation prepared by the method disclosed by the method has the advantages of high absorption rate, stable pharmacodynamic components, high bioavailability and the like under the condition that the pesticide effects of the raw preparation are remained.

Description

technical field [0001] The invention relates to a preparation of a pharmaceutical composition and a preparation method thereof, in particular to a preparation method of a medicinal preparation for treating stroke sequelae, leukemia, gout and joint disadvantage. technical background: [0002] Ruyi Zhenbao Pills, Tibetan medicine name: Sangpei Nuburibu; it is recorded in the classic work of Tibetan medicine "Supplement to Tibetan Medicine Jue" in the 15th century AD. The book "Pande Qiongnai" compiled by Situ Quejiqiongnai, a famous Tibetan medicine scientist in the 17th century, records the formula and functions of this prescription, and it is still used today. It is now included in the first volume of "Drug Standards of the Ministry of Health of the People's Republic of China Tibetan Medicine", the standard number is WS3-BC-0314-95. [0003] The prescription is mainly composed of 30 kinds of medicinal materials such as mother-of-pearl, agarwood, and licorice. It is used fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P9/10A61P19/02A61P19/06A61P29/00A61K31/122A61K33/06A61K35/32A61K35/413A61K35/56A61K35/612A61K35/618
Inventor 马振元邵成雷李丽李怀平孙绪丁刘玉芹
Owner JINHE TIBETAN MEDICINE
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