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Preparation method for ginkgo leaf extracts and preparation of ginkgo leaf extracts

A technology of ginkgo biloba and extract, which is applied in the field of preparation of ginkgo biloba extract, can solve the problems of ginkgo biloba modernization process constraints, high labor intensity of feeding and unloading, and low extract content, so as to promote cancer cell apoptosis and improve Gastritis, improvement of diabetes and complications

Active Publication Date: 2013-07-31
广东长兴生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solvent method has been using the traditional intermittent process of crushing and extraction for many years. The purpose of crushing the raw materials first is to speed up the extraction, but it also brings labor-intensive feeding and unloading, difficulty in liquid-solid separation, large solvent consumption, and high energy consumption. , low efficiency, unstable production, etc.
The domestic extraction technology of ginkgo biloba extract mainly uses water extraction or alcohol solvent extraction, and then adsorbed by macroporous resin. This method has a low extraction rate and the content of the obtained extract is not high.
[0005] my country is rich in ginkgo biloba resources, which account for about 70% of the world's total. The modern research on ginkgo biloba in China started relatively late. Due to the lack of standardized raw materials, production processes and preparation methods, the modernization process of ginkgo biloba-related industries has been affected. Restricted, presenting a situation of low-level duplication and unstable products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 : adopt following method to prepare Ginkgo biloba extract of the present invention:

[0019] (1) Select fresh and dried green leaves of Ginkgo biloba, dry them at 50°C, remove impurities, crush them, and pass through a 60-mesh sieve to obtain Ginkgo biloba powder;

[0020] (2) The ginkgo leaf powder obtained in step (1) is subjected to 5-stage countercurrent extraction with continuous circulation spraying of ethanol with a mass fraction of 60% using a continuous extractor. The extraction process conditions are: the solid-to-liquid ratio of ginkgo leaf and ethanol The ratio is 1:6, the extraction time is 6 hours, and the extraction temperature is 58°C;

[0021] (3) After the extraction is completed, the extract is distilled under reduced pressure to recover the ethanol in the extract, and the extract is obtained at the same time. The extract is concentrated to a Baume degree of 20 degrees, then vacuum-dried at 65°C, and crushed to 100 mesh. Obtain Ginkgo bilo...

Embodiment 2

[0023] Example 2 : adopt following method to prepare Ginkgo biloba extract of the present invention:

[0024] (1) Select fresh and dried green leaves of Ginkgo biloba, dry them at 55°C, remove impurities, crush them, and pass through a 70-mesh sieve to obtain Ginkgo biloba powder;

[0025] (2) The ginkgo leaf powder obtained in step (1) is subjected to 5-stage countercurrent extraction with continuous circulation of ethanol with a mass fraction of 70% using a continuous extractor. The extraction process conditions are: the solid-to-liquid ratio of ginkgo leaves and ethanol The ratio is 1:5.5, the extraction time is 5 hours, and the extraction temperature is 60°C;

[0026] (2) After the extraction is completed, the extract is distilled under reduced pressure to recover the ethanol in the extract, and the extract is obtained at the same time. The extract is concentrated to a Baume degree of 22 degrees, then vacuum-dried at 70°C, and crushed to 100 mesh. Obtain Ginkgo biloba e...

Embodiment 3

[0028] Example 3 : adopt following method to prepare Ginkgo biloba extract of the present invention:

[0029] (1) Select fresh and dried green leaves of ginkgo biloba, dry them at 60°C, remove impurities, crush them, and pass through a 60-mesh sieve to obtain ginkgo leaf powder;

[0030] (2) The ginkgo leaf powder obtained in step (1) is subjected to 5-stage countercurrent extraction by continuous spraying with ethanol with a mass fraction of 50% in a continuous extractor. The extraction process conditions are: the solid-to-liquid ratio of ginkgo biloba and ethanol The ratio is 1:5, the extraction time is 4 hours, and the extraction temperature is 55°C;

[0031] (3) After the extraction is completed, the extract is distilled under reduced pressure to recover the ethanol in the extract, and the extract is obtained at the same time. The extract is concentrated to a Baume degree of 25 degrees, then vacuum-dried at 65°C, and crushed to 100 mesh to obtain Ginkgo biloba extract w...

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PUM

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Abstract

The invention discloses a preparation method for ginkgo leaf extract and preparation of the ginkgo leaf extracts. Under the conditions that ratio of solid to liquid ranges from 1:5 to 1:6, extraction time is four hours to six hours and extraction temperature ranges from 55 DEG C to 60 DEG C, five-stage countercurrent extraction of treated ginkgo leaves is realized by ethanol with mass fraction of50% to 70%, process is reasonable, contents of effective components are high, extraction efficiency is high, operation is simple, and the preparation method meets conditions of industrial production.The invention further discloses preparation which is prepared by main raw materials including the ginkgo leaf extracts obtained by the preparation method, natto lyophilized powder, corn starch and magnesium stearate, and is used for preventing and treating cardiovascular and cerebrovascular diseases, and is simple in preparation method and low in cost.

Description

technical field [0001] The invention relates to a preparation method and preparation of ginkgo leaf extract. Background technique [0002] Ginkgo biloba is the dried leaf of Ginkgo biloba L., a plant of the family Ginkgoaceae. It is sweet, bitter, astringent, flat, and has the effects of astringing the lungs, relieving asthma, promoting blood circulation, removing blood stasis, and relieving pain. It is used clinically to improve Microcirculation, prevention and treatment of cardiovascular and cerebrovascular diseases, etc. Domestic research on the chemical constituents and pharmacological effects of Ginkgo biloba began in the 1960s, and successively developed preparations have been applied clinically and achieved good results. [0003] The chemical composition of Ginkgo biloba is very complex. So far, more than 160 compounds have been found in Ginkgo biloba, but the most important active ingredients are flavonoids and ginkgolides; Ginkgo flavonoids can resist free radicals...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61P9/00A61K127/00
Inventor 梁木鸿梁木林李建权杨志军张桂馥刘启华苏泽雄辜丽佳杨立凯卢君
Owner 广东长兴生物科技股份有限公司
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