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Method for preparing cellulose nanocrystal reinforced polyhydroxybutyrate-hydroxyvalerate (PHBV) nanofiber

A nanofiber and nanocrystal technology is applied in the field of preparation of PHBV nanofibers, which can solve the problems that the performance of PHBV nanofibers cannot be well improved, and achieve the effects of suitable hydrophilic properties, high thermal degradation temperature and low cost.

Inactive Publication Date: 2012-06-13
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Recently, researchers used plasma methods to coat biodegradable collagen organic compounds on the surface of PHBV nanofiber membranes, which greatly improved the hydrophilicity of the nanofiber surface, and cells can adhere, grow and differentiate well on the surface of the fiber membrane. , Proliferation, the deficiency is that the addition of collagen cannot improve other properties of PHBV nanofibers, such as mechanical properties, thermal properties, etc.

Method used

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  • Method for preparing cellulose nanocrystal reinforced polyhydroxybutyrate-hydroxyvalerate (PHBV) nanofiber
  • Method for preparing cellulose nanocrystal reinforced polyhydroxybutyrate-hydroxyvalerate (PHBV) nanofiber
  • Method for preparing cellulose nanocrystal reinforced polyhydroxybutyrate-hydroxyvalerate (PHBV) nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The cellulose nanocrystal dispersion liquid dispersed in N,N-dimethylformyl was slowly added to polyhydroxybutyrate valerate (number average molecular weight and molecular weight distribution were 4.5×10 4and 4.8) in the chloroform solution, wherein the total mass fraction of PHBV and CNCs in the mixed solution is 9wt%, the mass ratio of PHBV and CNCs is 99: 1, and the mass ratio of N,N-dimethylformamide and chloroform is 1:7.6; then the mixture was heated up to 70°C, fully stirred and swelled to obtain a transparent and uniform electrospinning stock solution; then the spinning solution prepared above was mixed in a needle tube with an inner diameter of 0.7mm and a flow rate of 1.8mL / h, Electrospinning was carried out under the spinning conditions of a voltage of 12kV and a receiving distance of 15cm, collected by a flat electrode, and the above product was vacuum-dried at room temperature for 24 hours to obtain PHBV / CNCs nanofibers or fiber membranes; the nanofibers wer...

Embodiment 2

[0029] The cellulose nanocrystal dispersion liquid dispersed in N,N-dimethylacetamide was slowly added to polyhydroxybutyrate valerate (number-average molecular weight and molecular weight distribution were 1.0×10 5 and 2.9) in the diethylene glycol dimethyl ether solution, wherein the total mass fraction of PHBV and CNCs in the mixed solution is 16wt%, and the mass ratio of PHBV and CNCs is 5: 1, N, N-dimethylacetamide The mass ratio of diethylene glycol dimethyl ether to diethylene glycol dimethyl ether is 1:9; then the mixed solution is heated up to 60°C, fully stirred and swollen to obtain a transparent and uniform electrospinning stock solution; Electrospinning was carried out under the spinning conditions of 0.7mm, flow rate of 1.5mL / h, voltage of 15kV and receiving distance of 18cm, collected by rotating drum, and the above product was vacuum dried at room temperature for 20h to obtain PHBV / CNCs nanofibers Or fiber film; the diameter of the nanofiber is 128nm obtained b...

Embodiment 3

[0031] The cellulose nanocrystal dispersion liquid dispersed in tetrahydrofuran was slowly added to polyhydroxybutyrate valerate (number average molecular weight and molecular weight distribution were 2.5×10 5 and 2.4) in the 1,2-chloroethane solution, wherein the total mass fraction of PHBV and CNCs in the mixed solution is 7wt%, the mass ratio of PHBV and CNCs is 49:1, tetrahydrofuran and 1,2-chloroethane The mass ratio of the mixed solution is 1:7.5; then the mixed solution is heated up to 58°C, fully stirred and swelled to obtain a transparent and uniform electrospinning stock solution; then the spinning solution prepared above is 0.7mm in the inner diameter of the needle tube and the flow rate is 1.0 Electrospinning was carried out under the spinning conditions of mL / h, voltage of 12kV and receiving distance of 14cm, collected by a rotating drum, and the above product was vacuum-dried at room temperature for 15h to obtain PHBV / CNCs nanofibers or fiber membranes; the nanofi...

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Abstract

The invention relates to a method for preparing cellulose nanocrystal reinforced polyhydroxybutyrate-hydroxyvalerate (PHBV) nanofiber. The method comprises the following steps of: (1), adding an organic solvent, namely a solution A, of cellulose nanocrystals (CNCs) into an organic solvent, namely a solution B, of a PHBV during stirring to obtain a mixed solution; (2), heating the mixed solution to 40 to 70 DEG C, fully stirring to obtain a transparent and uniform electrostatic spinning stock solution; and (3), performing electrostatic spinning on the stock solution, performing vacuum drying on the stock solution at room temperature to obtain the PHBV or CNCs. The method is simple, controllable, quick and efficient. The prepared PHBV or CNCs is or are a complete biodegradation product, has high biodegradability and biocompatibility, high porosity, adjustable aperture and tailorable shapes, and has the advantages of high mechanical property, high thermal property, appropriate hydrophilcity and the like.

Description

technical field [0001] The invention belongs to the field of preparation of PHBV nanofibers, in particular to a method for preparing PHBV nanofibers reinforced by cellulose nanocrystals. Background technique [0002] The unique structural properties of nanofibers produced by electrospinning, such as high specific surface area, low fiber net weight and high porosity, make them have huge market potential in fields such as medical and health products. For example, when making cell engineering scaffold materials, the role of nanofibers is to provide conductivity and structural support, and improve the porosity of the scaffold; used in drug packaging, it can control the transmission of active components. The nanofiber material is also an ideal bandage for burn patients. Nanofibers can be used in artificial blood vessels, drug delivery materials, etc., and are also widely used in personal care products such as wipes and paper towels. In particular, the integration of biodegradab...

Claims

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Application Information

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IPC IPC(8): D01F8/14D01F8/02D01D1/02D01D5/00
Inventor 秦宗益余厚咏刘彦男周哲
Owner DONGHUA UNIV
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