Method for preparing Poria cocos granules by replacing part of auxiliary materials with ultrafine powder

A formula granule and superfine powder technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of low extraction rate of Poria cocos decoction pieces, increased production costs, and large energy consumption. , to achieve better taste, increased hydrophilicity and good taste

Active Publication Date: 2012-07-04
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, on the one hand, the extraction rate of Poria cocos decoction pieces is low, and only more than 10 kg of extract can be obtained per 1 ton of Poria cocos decoction pieces, and most of the β-poria cocos polysaccharides are discarded as medicinal residues, which not only wastes a large amount of medicinal mater

Method used

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  • Method for preparing Poria cocos granules by replacing part of auxiliary materials with ultrafine powder
  • Method for preparing Poria cocos granules by replacing part of auxiliary materials with ultrafine powder
  • Method for preparing Poria cocos granules by replacing part of auxiliary materials with ultrafine powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 98 kg of Poria cocos decoction pieces, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours; add 7 times the amount of water for the second time, decoct for 1 hour, filter the liquid medicine, and concentrate in a vacuum (vacuum degree -0.05~-0.07MPa, 60~70°C) until the total amount of liquid medicine is 5L, pass through a 180-mesh sieve to obtain a concentrated solution of Poria cocos for future use;

[0047] Take 2 kg of Poria decoction pieces, crush them with a high-speed pulverizer, pass through an 80-mesh sieve, and pulverize them with an airflow pulverizer, adjust the frequency of the grading impeller to 35 Hz, collect ultrafine powder with a particle size of less than 500 mesh, add 5 L of water, and then add 0.8 kg of maltodextrin , heated and boiled for 20 minutes, then stood still for 30 minutes, stirred evenly, adjusted the speed of the colloid mill to 3000 rpm, adjusted the gap between the stator and rotor of t...

Embodiment 2

[0050] Take 98.5kg of Poria cocos decoction pieces, add water to decoct twice, add 9 times the amount of water for the first time, decoct for 1 hour; add 6 times the water for the second time, decoct for 1 hour, filter the liquid medicine, vacuum Concentrate (vacuum degree -0.05~-0.07MPa, 60~70°C) until the total amount of medicinal solution is 8L, pass through a 350-mesh sieve to obtain Poria cocos concentrate;

[0051] Take 1.5 kg of Poria cocos decoction pieces, pulverize them with a high-speed pulverizer, pass through a 100-mesh sieve, and pulverize them with an airflow pulverizer, adjust the frequency of the grading impeller to 30 Hz, collect ultrafine powder with a particle size of less than 500 mesh, add 8 L of Poria cocos concentrate, add β- Cyclodextrin 0.6kg, heat and boil for 30 minutes, then stand still for 30 minutes, stir evenly, control the temperature of the feed liquid at 65°C~75°C, adjust the speed of the colloid mill to 2500 rpm, and adjust the gap between th...

Embodiment 3

[0054] Take 97kg of Poria decoction pieces, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours; add 7 times the amount of water for the second time, decoct for 1 hour, filter the liquid medicine, and concentrate in vacuo (vacuum degree -0.05~-0.07MPa, 60~70°C) until the total amount of liquid medicine is 5L, pass through a 180-mesh sieve, control the inlet air temperature at 160~170°C, the outlet air temperature at 85~95°C, and the negative pressure in the tower- 0.01~-0.05MPa, collect the spray-dried powder to obtain Poria cocos concentrated powder;

[0055] Take 3 kg of Poria decoction pieces, pulverize them with a high-speed pulverizer, pass through a 80-mesh sieve, pulverize with an airflow pulverizer, adjust the frequency of the grading impeller to 35 Hz, collect ultrafine powder with a particle size of less than 500 mesh, add 12 L of water, add 1 kg of maltodextrin, and heat Boil for 20 minutes, then stand still for 30 minut...

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Abstract

The invention relates to a method for preparing Poria cocos granules by replacing part of auxiliary materials with ultrafine powder. The method comprises the following steps of: (1), taking a Poria cocos decoction tablet, adding water to decoct the Poria cocos decoction tablet once or twice, filtering the decoction, and performing vacuum concentration to obtain a Poria cocos concentrated solutionA, or performing spray drying to obtain a Poria cocos concentrated powder B; (2) taking a Poria cocos decoction tablet, performing micronization, collecting micropowder with the particle diameter of less than 500 meshes, adding water or adding the Poria cocos concentrated solution A obtained in the step (1), adding a proper amount of starch medicinal auxiliary materials, heating and boiling, and milling with a colloid mill once or twice to obtain a Poria cocos micropowder milled solution C, or performing spray drying to obtain a Poria cocos micropowder milled powder D; and (3), uniformly mixing the obtained Poria cocos concentrated solution A and the obtained Poria cocos micropowder milled solution C, and performing spray drying; or uniformly mixing the Poria cocos concentrated powder B and the Poria cocos micropowder milled powder D, and granulating and packaging. By the preparation method, the problem that power floats in the dissolving and orally taking process can be effectively solved, the dissolving dispersibility of the micropowder is improved, the content of an active component Poria cocos polysaccharide is increased, and the using amount of the auxiliary materials is reduced.

Description

technical field [0001] The invention relates to a preparation method of traditional Chinese medicine granules, in particular to a preparation method of poria cocos formula granules in which superfine powder is used to replace part of auxiliary materials, and belongs to the technical field of traditional Chinese medicine formula granules. Background technique [0002] Poria cocos Poria cocos (Schw.) Dried sclerotia of Wolf. Functions and indications are diuresis and dampness expelling, invigorating the spleen, calming the heart, mainly used for edema, oliguria, dizziness and palpitation due to phlegm retention, deficiency of the spleen, lack of food, loose stool, restlessness, palpitation and insomnia. The main chemical components are β-pachyan and triterpenoids acetyl pachynic acid, pachymic acid, and 3β-hydroxylanostenoic acid. In addition, it still contains gum, chitin, protein, fat, sterol, lecithin, histidine, choline and lithium salt. [0003] Modern studies believe ...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61K9/16A61K47/36A61P1/12A61P1/14A61P1/16A61P7/10A61P25/20A61P29/00A61P35/00A61P39/06A61P43/00
Inventor 谭登平刘法锦魏梅陈向东练林
Owner GUANGDONG YIFANG PHARMA
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