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Medicinal composition with anti-inflammatory and analgesic effects

An anti-inflammatory and analgesic, composition technology, applied in the field of pharmaceutical compositions containing active ingredient aceclofenac, can solve problems such as side effects, mucosal damage and the like

Active Publication Date: 2012-07-11
四川维奥制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The aceclofenac preparations on the market mainly include ordinary tablets, dispersible tablets, sustained-release tablets, and enteric-coated tablets and enteric-coated capsules to reduce the gastrointestinal side effects caused by aceclofenac. Studies have shown that non-steroidal anti-inflammatory drugs The main cause of gastrointestinal side effects is caused by the mechanism of action of this type of drug, and another important reason is that this type of drug can directly stimulate the lipoprotein layer of epithelial cells on the gastric mucosa, causing mucosal damage, thereby producing side effects; in clinical During the application process, the enteric-coated preparations of aceclofenac have gastrointestinal side effects. Studies have found that the existing enteric-coated preparations, especially commercially available enteric-coated tablets, have certain release in the stomach. Therefore, the research Developing a new enteric-coated pharmaceutical composition with aceclofenac as a raw material, reducing its release in the stomach, is of great significance for improving product quality, reducing adverse reactions, and increasing patient compliance

Method used

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  • Medicinal composition with anti-inflammatory and analgesic effects
  • Medicinal composition with anti-inflammatory and analgesic effects
  • Medicinal composition with anti-inflammatory and analgesic effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] A pharmaceutical composition with anti-inflammatory and analgesic effects, the pharmaceutical composition comprises 100g of aceclofenac, 35g of microcrystalline cellulose, 35g of pregelatinized starch, 8g of hydroxypropyl cellulose, 1.5g of lubricant micropowder silica gel, poly Vinyl acetate phthalate 30g.

[0078] Above-mentioned pharmaceutical composition is prepared into enteric-coated tablet, and its preparation method is:

[0079] Preparation of plain tablets: take aceclofenac and grind it, pass through a 100-mesh sieve, mix completely with microcrystalline cellulose, pregelatinized starch and hydroxypropyl cellulose passed through a 100-mesh sieve, and use 5% starch slurry in an appropriate amount to make a soft tablet. material, granulated with a 20-mesh sieve, dried, granulated, added with a lubricant passed through a 100-mesh sieve, mixed completely, and compressed into tablets to obtain plain tablets;

[0080] Coating: Get 3.3g of polyvinyl acetate phthalate...

Embodiment 2

[0084] A pharmaceutical composition with anti-inflammatory and analgesic effects, the pharmaceutical composition comprises 100g of aceclofenac, 35g of microcrystalline cellulose, 35g of pregelatinized starch, 8g of hydroxypropyl cellulose, 1.5g of lubricant micropowder silica gel, poly Vinyl acetate phthalate 30g, polyacrylic resin III 1g.

[0085] Above-mentioned pharmaceutical composition is prepared into enteric-coated tablet, and its preparation method is:

[0086] Preparation of plain tablets: take aceclofenac and grind it, pass through a 100-mesh sieve, mix completely with microcrystalline cellulose, pregelatinized starch and hydroxypropyl cellulose passed through a 100-mesh sieve, and use 5% starch slurry in an appropriate amount to make a soft tablet. material, granulated with a 20-mesh sieve, dried, granulated, added with a lubricant passed through a 100-mesh sieve, mixed completely, and compressed into tablets to obtain plain tablets;

[0087] Coating: Get 3.3g of p...

Embodiment 3

[0091] A pharmaceutical composition with anti-inflammatory and analgesic effects, the pharmaceutical composition comprises 100g of aceclofenac, 45g of microcrystalline cellulose, 45g of pregelatinized starch, 12g of hyprolose, 3g of lubricant magnesium stearate, Polyvinyl acetate phthalate 35g.

[0092] Above-mentioned pharmaceutical composition is prepared into enteric-coated tablet, and its preparation method is:

[0093] Preparation of plain tablets: take aceclofenac and grind it, pass through a 100-mesh sieve, mix completely with microcrystalline cellulose, pregelatinized starch and hydroxypropyl cellulose passed through a 100-mesh sieve, and use 5% starch slurry in an appropriate amount to make a soft tablet. material, granulated with a 20-mesh sieve, dried, granulated, added with a lubricant passed through a 100-mesh sieve, mixed completely, and compressed into tablets to obtain plain tablets;

[0094] Coating: get 4.9g polyvinyl acetate phthalate, add ethanol, be mixed...

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Abstract

The invention which belongs to the technical field of medicines discloses a medicinal composition with anti-inflammatory and analgesic effects. The medicinal composition is characterized in that the medicinal composition comprises aceclofenac, a microcrystalline cellulose, pregelatinized starch, a hydroxypropyl cellulose, a lubricant and polyvinyl acetate phthalate; or the medicinal composition comprises aceclofenac, the microcrystalline cellulose, the pregelatinized starch, the hydroxypropyl cellulose, the lubricant, polyvinyl acetate phthalate and a polyacrylic resin III. The medicinal composition of the invention is determined through a disintegration test, a release degree test and the like, and medicinal preparations prepared from the medicinal composition of the invention have the excellent quality characteristics.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing aceclofenac as an active ingredient. Background technique [0002] Aceclofenac was launched in Spain for the first time in 1992, and has since been launched in Sweden, the United Kingdom, Belgium and other countries. Animal experiments show that the anti-inflammatory effect of this product is similar to that of diclofenac, stronger than that of naproxen; its ulcerative effect is 4-7 times lower than that of indomethacin and diclofenac. This product can still increase the synthesis of chondrocytes, which is not found in most NSAIDs. In the clinical research, 1788 patients took aceclofenac, and 1786 patients in the control group took diclofenac sodium, indomethacin (indomethacin), naproxen, pyroxicam, etc. The results show that this product is better than other common NSAIDs in terms of overall and gastrointestinal safety, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/32A61K31/216A61K47/32A61P29/00
Inventor 曹捷高帆周战尚磊
Owner 四川维奥制药有限公司
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