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Externally applied disinfectant for treating vaginitis and preparation method thereof

A disinfectant and vaginitis technology are applied in the field of external use disinfectant for treating gynecological vaginitis and the field of preparation thereof, so as to achieve the effect of exerting a therapeutic effect and solving the demand for medication

Inactive Publication Date: 2012-07-11
合肥华威药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the preparation process of this product, the volatile active ingredients (volatile oil) with antibacterial activity contained in Artemisia argyi and other substances were not collected and utilized.

Method used

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  • Externally applied disinfectant for treating vaginitis and preparation method thereof
  • Externally applied disinfectant for treating vaginitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 6 grams of mugwort leaves crushed through a 20-mesh sieve, 15 grams of cnidium, 1.5 grams of rhubarb, 2.5 grams of atractylodes, 0.2 grams of incense, 0.4 grams of comfrey and soak in 15 times the amount of water for 1 hour, steam distillation to collect volatile oil until No volatile oil escapes, add 5ml Tween-80 to the oil-water mixture and mix well. The raffinate is separated by filtration to obtain the water extract (I) and medicinal residues. Add 40 grams of Phellodendron Phellodendri to the dregs, put it in a multi-functional extraction tank, add 12 times the amount of water to soak for 1 hour, decoct for 1 hour, filter and separate the decoction to obtain the water extract (II), add 10 times the amount of water to the dregs, and then Decoct for 1 hour, cool and filter the decoction to obtain water extract (III). Combine the water extracts (I), (II) and (III), let stand below 10°C for 48 hours, and filter to obtain the water extract. Heat the water extract ...

Embodiment 2

[0036] Take 5 grams of Artemisia argyi, 10 grams of Fructus Cnidii, 1 gram of Rhubarb, 2 grams of Atractylodes atractylodes, 0.1 gram of Jiangxiang, 0.1 gram of Comfrey plus 15 times the amount of water and soak for 1 hour, and the subsequent operations are the same as in Example 1 to obtain volatile oil and water extraction. liquid. Heat the water extract to 50-60°C, add 10 grams of domiphene, 1 gram of chlorhexidine acetate, and 10 grams of terbinafine hydrochloride under stirring, and cool to room temperature after completely dissolving. Add 1 gram of borneol and 1 gram of menthol, add 25 ml of ethanol to dissolve, combine with the above-mentioned volatile oil, stir well, add to the above-mentioned cooled filtrate, continue to add distilled water to 10000 ml, and adjust the pH value to 4-5 with benzoic acid.

Embodiment 3

[0038] Take 8 grams of Artemisia argyi leaves, 20 grams of Fructus Cnidii, 2 grams of Rhubarb, 3 grams of Atractylodes atractylodes, 0.3 grams of Jiangxiang, 0.6 grams of Comfrey and soak in 15 times the amount of water for 1 hour. The subsequent operations are the same as in Example 1 to obtain volatile oil and water extraction. liquid. Heat the water extract to 50-60°C, add 20 grams of domiphene, 5 grams of chlorhexidine acetate, and 30 grams of terbinafine hydrochloride under stirring, and cool to room temperature after completely dissolving. Add 3 grams of borneol and 3 grams of menthol, add 80 ml of ethanol to dissolve, combine with the aforementioned volatile oil, stir well and add to the above-mentioned cooled filtrate, continue to add distilled water to 10000 ml, and adjust the pH value to 4-5 with benzoic acid.

[0039] (2) Effect test

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PUM

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Abstract

The invention discloses an externally applied disinfectant for treating vaginitis. Each 1,000mL of the disinfectant contains a volatile oil component extracted from 0.5 to 0.8g of folium artemisiae argyi, 1 to 2g of fructus cnidii, 0.1 to 0.2g of rhubarb, 0.2 to 0.3g of atractylodes lancea, 0.01 to 0.03g of rosewood heart wood and 0.02 to 0.06g of lithospermum purpurocaeruleum, a water-soluble component which is extracted by using water obtained by mixing of the dregs of the folium artemisiae argyi, the fructus cnidii, the rhubarb, the atractylodes lancea, the rosewood heart wood and the lithospermum purpurocaeruleum and 2 to 6g of phellodendron, 0.1 to 0.3g of borneol, 0.1 to 0.3g of menthol, 1 to 2g of domiphen bromide, 0.1 to 0.5g of chlorhexidine acetate, 1 to 3g of terbinafine hydrochloride, 0.25 to 0.75g of tween 80 and benzoic acid at the pH value of 4 to 6. The disinfectant has good curative effects on bacterial, mycotic and trichomonas vaginitis, does not cause allergic reaction and other adverse reaction, and does not pollute pants.

Description

1. Technical field [0001] The invention relates to a gynecological external-use disinfectant and a processing method thereof, in particular to an external-use disinfectant for treating gynecological vaginitis and a preparation method thereof. 2. Background technology [0002] Vaginitis and genital itching are common gynecological diseases. Common vaginitis includes bacterial vaginitis, trichomonal vaginitis, fungal (mainly Candida) vaginitis, and senile vaginitis. Dr. Garder and others have studied 1181 cases of vaginitis and found that 41% were bacterial, 27% were fungal, and 24% were trichomonas. [0003] Traditional Chinese medicine treats vaginitis from the whole, and treats it by clearing away dampness and heat, killing insects and relieving itching. At the same time, the method of flushing for external use improves the concentration of the drug lesion and reduces systemic toxic and side effects. Western medicine uses various antibacterial drugs to directly kill vario...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P15/02A61P31/04A61P31/10A61P33/02A61P31/02A61K31/045A61K31/137A61K31/155
Inventor 李贵华
Owner 合肥华威药业有限公司