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Porous hydroxyapatite ceramic with fluorescence labeling characteristic, and preparation method thereof

A hydroxyapatite and fluorescent labeling technology is applied in the fields of biomedical materials and optical functional materials, which can solve the problems of low porosity and uneven material voids, and achieve the effects of high porosity, simple preparation process, and easy popularization and application.

Inactive Publication Date: 2014-04-02
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to overcome the gaps in the prior art and the problems of uneven voids and low porosity of prepared materials, and provide a material with adjustable pore size and porosity, good biocompatibility, and capable of effective in vitro and in vivo tests. High-porosity ceramics with a three-dimensional connected structure with detection and diagnosis functions and a preparation method thereof, realized through the following technical solutions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A. Eu(NO 3 ) 3 and a calcium hydroxide solution with a concentration of 0.01mol / L, the Eu(NO 3 ) 3 dissolved in calcium hydroxide solution to obtain solution I;

[0032] B. Prepare a phosphoric acid solution with a concentration of 0.006mol / L;

[0033] C. Press R E The molar ratio of ions, Ca ions and phosphoric acid ions is 0.01︰0.99︰0.6, take the solution I obtained in step A and the phosphoric acid solution obtained in step B, mix the obtained solution I and the phosphoric acid solution under 50w ultrasonic treatment, and add alkali at the same time Adjust the pH value of the solution to 10 to form a suspension system II of nano-hydroxyapatite sol;

[0034] D. The suspension system II obtained in step C was naturally aged for 24 hours at 20°C, washed and dried at 80°C for 12 hours, and the chemical composition formula was Ca 0.99 Eu 0.01 (PO 4 ) 0.6 (OH) 0.2 Fluorescently labeled hydroxyapatite powder;

[0035] E. The fluorescently labeled hydroxyapat...

Embodiment 2

[0040] A. Press R E The molar ratio of ions to Ca ions is 0.1:0.9, taking Er(NO 3 ) 3 , Ho(NO 3 ) 3 and calcium nitrate solution with a concentration of 0.2mol / L, Er(NO 3 ) 3 and Ho(NO 3 ) 3 Dissolved in calcium nitrate solution to obtain solution I;

[0041] b. Prepare a diammonium hydrogen phosphate solution with a concentration of 0.133 mol / L;

[0042] c. Press R E The molar ratio of ion, Ca ion and phosphoric acid ion is 0.1:0.9:0.6, take the solution I obtained in step A and the diammonium hydrogen phosphate solution obtained in step B, take the solution I and the diammonium hydrogen phosphate solution, under 20w ultrasonic treatment Mixing, and adding an alkaline solution to adjust the pH to 10.5 to form a suspension system II of nano-hydroxyapatite sol;

[0043] D. The suspension system II obtained in step C is placed in an autoclave for 24 hours at 160 ° C, and then washed and freeze-dried to obtain the chemical composition formula of Ca. 0.9 Er 0.05 Ho...

Embodiment 3

[0049] A. Press R E The molar ratio of ions to Ca ions is 0.09:0.91, taking Sm (NO 3 ) 3 , Tm(NO 3 ) 3 , Tb(NO 3 ) and calcium nitrate solution with a concentration of 1 mol / L, the Sm (NO 3 ) 3 , Tm(NO 3 ) 3 , Tb(NO 3 ) is dissolved in calcium nitrate solution to obtain solution I;

[0050] b. Prepare disodium hydrogen phosphate solution with a concentration of 1.099mol / L;

[0051] c. Press R E The molar ratio of ion, Ca ion and phosphoric acid ion is 0.09:0.91:0.6, take the solution I obtained in step A and the disodium hydrogen phosphate solution obtained in step B, and the solution I and disodium hydrogen phosphate solution are taken, under 80w ultrasonic treatment Mixing, and adding an alkaline solution to adjust the pH to 11 to form a suspension system II of nano-hydroxyapatite sol;

[0052] D. The suspension system II obtained in step C was aged at 80°C in an 80W ultrasonic field for 24 hours, and after washing and freeze-drying, the chemical composition ...

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Abstract

The invention provides a porous hydroxyapatite ceramic with fluorescence labeling characteristic, and a preparation method thereof. The porous hydroxyapatite ceramic has the aperture of 20-300mu m, the porosity of 60-90% and the chemical composition formula of Ca1-x REx (PO4)0.6 (OH)0.2, wherein x is equal to 0.005-0.1, and RE is one or more of Eu, Er, Ho, Pr, Tm, Sm and Tb; and the preparation method of the porous hydroxyapatite ceramic comprises the following steps of: preparing a mixed solution of calcium salt and RE(NO3)3 and a phosphate solution or phosphoric acid, fully mixing the mixed solution and the phosphate solution or the phosphoric acid under the condition of ultrasonic processing, ageing and drying, thus obtaining hydroxyapatite powder with the fluorescence labeling characteristic; then, adding the powder into a polyving akohol water solution together with polymer microspheres and inorganic porous agent, and evenly mixing; and finally, molding and sintering, thus obtaining the porous hydroxyapatite ceramic with the fluorescence labeling characteristic. The porous hydroxyapatite ceramic prepared by the invention is high in porosity, and has a three-dimensional communicating structure, thus being beneficial to the combination and growth of fibrous tissues and regenerated new bones; and furthermore, the porous hydroxyapatite ceramic is simple in preparation process and concise in operation.

Description

technical field [0001] The invention relates to the technical field of biomedical materials and optical functional materials, in particular to a porous hydroxyapatite ceramic with fluorescent labeling properties and a preparation method thereof. Background technique [0002] The chemical composition of hydroxyapatite is very similar to the inorganic composition of human bone, and the crystal structure is also similar. After being implanted in the human body, it has good biological activity and biocompatibility, and has no toxic side effects on the human body. Therefore, porous hydroxyapatite ceramics are considered It is the most promising surface active bioceramic. Its interconnected pores are conducive to the microcirculation of interstitial fluid, and provide nutrition for the new bone in the deep part of hydroxyapatite, and promote the combination and growth of fibrous tissue and new bone. A bone tissue substitute material with excellent performance. However, effective ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622
Inventor 邱建备尹兆益宋志国杨正文周大成徐圆圆余雪
Owner KUNMING UNIV OF SCI & TECH