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Method for preparing incarvillea ester alkali

A technology for carotene base and Artemisia annua, which is applied in the field of preparing carrageenine by membrane separation and macroporous resin separation, can solve the problems of large dosage of toxic organic reagents, low extraction efficiency and the like, and achieves high extraction efficiency and short time. , the effect of low energy consumption

Inactive Publication Date: 2012-07-11
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned above, the existing process has the defects of a large amount of waste liquid generated in the production process, a large amount of toxic organic reagents, and low extraction efficiency.

Method used

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  • Method for preparing incarvillea ester alkali

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Artemisia annua medicinal material is used as raw material, pulverized, take 10kg, put into microwave extraction tank, add 100kg80% methanol solution, extract for 30 minutes, extract twice, combine extracts to recover methanol under reduced pressure, add hydrochloric acid to the concentrated solution to adjust pH1, add appropriate amount of water to dilute, Ceramic membrane filtration, the filtrate is added to the nanofiltration membrane tubular membrane nanofiltration with a molecular weight cut off of 1000, the permeate is added to a D101 macroporous resin resin column, the column liquid is collected, and the nanofiltration membrane tubular membrane nanofiltration with a molecular weight cut off of 100 is added to obtain Concentrate 2kg, adjust the pH of the concentrate to 10 with ammonia water, add 1L petroleum ether-chloroform mixed solution (1:3) for extraction, extract 3 times, collect the organic layer and concentrate it to 200ml, refrigerate and crystallize, and t...

Embodiment 2

[0025] Artemisia annua medicinal material is used as raw material, crushed, 10kg is taken, put into a microwave extraction tank, add 70kg of 60% methanol solution, extract for 1 hour, extract 3 times, combine extracts to recover methanol under reduced pressure, add hydrochloric acid to the concentrated solution to adjust pH3, add appropriate amount of water to dilute, Microfiltration membrane filtration, the filtrate is added to the nanofiltration membrane with a molecular weight cut off of 700 tubular membrane nanofiltration, the permeate is added to the AB-8 macroporous resin resin column, the column liquid is collected, and the nanofiltration membrane with a molecular weight cut off of 100 is added to the tubular membrane nanofiltration Filter to obtain 1.5kg of concentrated solution, adjust the pH of the concentrated solution to 12 with ammonia water, add 0.8L petroleum ether-chloroform mixed solution (2:7) for extraction, extract 3 times, collect the organic layer and conce...

Embodiment 3

[0027] Artemisia annua medicinal material is used as raw material, pulverized, take 10kg, put into microwave extraction tank, add 70kg of 70% methanol solution, extract for 1 hour, extract twice, combine extracts to recover methanol under reduced pressure, add hydrochloric acid to the concentrated solution to adjust pH2, add appropriate amount of water to dilute, Ultrafiltration membrane filtration, the filtrate is added to the nanofiltration membrane with a molecular weight cut-off of 800, the permeate is added to the HZ816 macroporous resin resin column, the column liquid is collected, and the nanofiltration membrane with a molecular weight cut-off of 100 is added to the tubular membrane nanofiltration. Get 2kg of concentrated solution, adjust the pH of the concentrated solution to 9 with ammonia water, add 1L of petroleum ether-chloroform mixed solution (1:4) for extraction, extract twice, collect the organic layer and concentrate it to 220ml, refrigerate and crystallize, and...

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Abstract

The invention relates to a method for preparing incarvillea ester alkali. The method comprises the following steps of: adopting incarvillea medicinal materials as raw materials, crushing, adding 60-80% methanol solution with the weight being 7-10 times that of the incarvillea medicinal materials, carrying out microwave extraction for 2-3 times, carrying out pressure reduction on extracted liquid to recover methanol, adding hydrochloric acid into concentrated liquid to adjust the pH to be 1-3, adding a nanofiltration membrane system for nanofiltration after filtering, adding macroporous resin columns into penetrating liquid, adding lower column liquid into the nanofiltration membrane system for nanofiltration, adjusting the pH of the concentrated liquid to be 9-12, adding oil ether-chloroform mixing solution for extraction, collecting organic layers, concentrating, refrigerating for crystallization, dissolving the crystals by alcohol backflow, crystallizing for 2-3 times, carrying out low-temperature drying and obtaining the incarvillea ester alkali. The incarvillea ester alkali prepared by adopting the method has the advantages that the energy consumption is low, the pollution is less, the preparation process is simple, safe and easy to implement, and the industrial production is easy to realize.

Description

Technical field: [0001] The invention relates to a method for preparing kerartesinate base, in particular to a method for preparing keratinate base by membrane separation and macroporous resin separation. Background technique: [0002] Carotene is a monoterpene alkaloid, soluble in chloroform, benzene, ether, and acidic water, soluble in methanol, ethanol, and acetone, insoluble in petroleum ether and water. [0003] Molecular formula: C 11 h 22 NO. [0004] Molecular Structure: [0005] [0006] Artemisinin has analgesic effect, its activity is higher than that of morphine, and its mechanism of action is different from that of morphine, mainly through μ, κ and adenosine receptors. At present, cartilage artemisinin has become an important lead compound for the development of new non-narcotic strong analgesic drugs. [0007] Artemisia sinensis (Incarvillea sinensis) is a plant of the Bignoniaceae family and one of the main sources of Sperancis, known as "Speranus sine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/04
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司
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