Glucosamine cataplasm, preparation method thereof and application

A technology of glucosamine and glucosamine hydrochloride, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., and can solve the problems of poor experience of patients, no significant breakthrough in cataplasms, and water content of preparations. Low-level problems, to achieve the effect of easy large-scale application, low production cost, and stable blood drug concentration

Active Publication Date: 2012-07-25
广东创药联和医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] There have been nearly ten years of research on cataplasms, but no significant breakthrough has been made in the research of matrix materials of cataplasms in China. The prepared preparations have low water content, and the surface is dry after drug loading, which makes patients feel bad when using them.

Method used

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  • Glucosamine cataplasm, preparation method thereof and application
  • Glucosamine cataplasm, preparation method thereof and application
  • Glucosamine cataplasm, preparation method thereof and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] New type of cataplasm for glucosamine

[0038] Prescription ratio:

[0039] D-glucosamine hydrochloride 100g

[0040] New cataplasm base 1000g

[0041] Wherein: the composition of novel cataplasm matrix is ​​as follows:

[0042]

[0043] Preparation:

[0044] First, prepare a new type of cataplasm base, take polyacrylic acid, polyvinylpyrrolidone, glycerin, kaolin, and polyethylene glycol, and mix them evenly with a cataplasm base mixing equipment to make 1000g. Then D-glucosamine hydrochloride is mixed evenly with the prepared new cataplasm base, coated on non-woven fabric with cataplasm coating equipment, covered with polyethylene film, cut according to requirements, and sealed for packaging.

Embodiment 2

[0046] New type of cataplasm for glucosamine

[0047] Prescription ratio:

[0048] D-Glucosamine Sulfate 10g

[0049] New cataplasm base 1000g

[0050] Wherein: the composition of novel cataplasm matrix is ​​as follows:

[0051]

[0052] Preparation:

[0053] First, prepare a new type of cataplasm base, take polyacrylic acid, methylcellulose, kaolin, glycerin, and propylene glycol, and mix them evenly with a cataplasm base mixing equipment to make 1000 g. Then D-glucosamine sulfate is mixed evenly with the prepared new-type cataplasm base, coated on non-woven fabric with cataplasm coating equipment, covered with polyethylene film, cut according to requirements, and sealed for packaging.

Embodiment 3

[0055] New type of cataplasm for glucosamine

[0056] Prescription ratio:

[0057] D-Glucosamine Sulfate 30g

[0058] D-glucosamine hydrochloride 20g

[0059] New cataplasm base 750g

[0060] Wherein: the composition of novel cataplasm matrix is ​​as follows:

[0061]

[0062]

[0063] Preparation:

[0064] First prepare a new type of cataplasm base, take gum arabic, gelatin, micro-powder silica gel, zinc oxide, and polyethylene glycol, and mix them evenly with a cataplasm base mixing equipment to make 750g. Then mix D-glucosamine sulfate and D-glucosamine hydrochloride with the prepared new-type poultice matrix evenly, apply poultice coating equipment on the non-woven fabric, cover polyethylene film, press It needs to be cut, sealed and packaged.

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Abstract

The invention discloses a novel glucosamine cataplasm. D-glucosamine hydrochloride and / or D-glucosamine sulfate are mixed with novel cataplasm matrix to form the novel cataplasm, and the novel cataplasm is used for treating osteoarthritis in an external use manner. Generally, from 1 to 10 parts of the D-glucosamine hydrochloride and / or the D-glucosamine sulfate are mixed with from 10 to 100 parts of the novel cataplasm matrix to form the novel cataplasm, and the novel cataplasm is externally used and attached on a wounded part and is used for treating osteoarthritis. Compared with a traditional externally used preparation, particularly a traditional cataplasm, the glucosamine cataplasm is simpler in manufacturing process and brings more convenience for industrialization. As the novel cataplasm matrix is adopted, a transdermal agent necessarily added in a traditional externally used preparation is omitted, and the glucosamine cataplasm is simpler in composition and lower in cost.

Description

technical field [0001] The invention relates to a new type of cataplasm for glucosamine, in particular to mixing D-glucosamine hydrochloride and / or D-glucosamine sulfate with a new type of cataplasm base to prepare a new type of glucosamine cataplasm agent. In addition, the present invention also relates to the preparation method and application of the glucosamine poultice. Background technique [0002] Osteoarthritis (OA) is a chronic joint disorder syndrome characterized by progressive damage to articular cartilage, and is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone hyperplasia. Osteoarthritis belongs to the categories of "gubi" and "kneebi" in traditional Chinese medicine. [0003] Osteoarthritis is also known as degenerative joint disease and proliferative osteoarthritis. The different names come from the pathological manifestations of joint disease, that is, cartilage degeneration is accompanied by new bone for...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/7008A61P19/02A61P29/00
Inventor 张继全阮克锋冯怡
Owner 广东创药联和医药科技有限公司
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