Preparation method for water-soluble fluorescent nuclear shell nanometer particles

A core-shell nanomaterial, water-soluble technology, applied in the direction of microsphere preparation, microcapsule preparation, etc., to achieve the effect of low equipment requirements, wide application prospects, and simple preparation process

Inactive Publication Date: 2012-07-25
BEIJING UNIV OF CHEM TECH
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  • Claims
  • Application Information

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Problems solved by technology

The advantage of the second method over the first method is that the distance between the noble metal and the organic fluorescent molecule can be adjusted to control the degree of fluorescence enhancement of the noble metal, and the aqueous phase dispersion can be achieved through surface modification, but this method is only applicable to a few species. Water-Soluble Organic Fluorescent Molecules

Method used

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  • Preparation method for water-soluble fluorescent nuclear shell nanometer particles
  • Preparation method for water-soluble fluorescent nuclear shell nanometer particles
  • Preparation method for water-soluble fluorescent nuclear shell nanometer particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) 243mg (0.36mmol) tetraphenyl zinc porphyrin (ZnTPP) was dissolved in 5ml methylene chloride; 51mg (0.20mmol) I 2 Dissolve in 5ml dichloromethane; 83mg (0.40mmol) AgClO 4 Dissolve in 0.75ml acetonitrile; 2 solution of dichloromethane and AgClO 4 The acetonitrile solution of ZnTPP is added in the dichloromethane solution of ZnTPP, and the gained precipitate is washed and dried with petroleum ether and dissolved in acetonitrile to obtain a cationic free radical solution of 1mmol / L ZnTPP;

[0037] The reaction formula is: ZnTPP+1 / 2I 2 +AgClO 4 →AgI+ZnTPP + ClO 4 -

[0038] 2) Under the conditions of sealing, light-blocking and magnetic stirring, add 2ml 1mmol / L ZnTPP cationic radical solution into 1ml 10mmol / L Ag nanoparticle acetonitrile suspension in turn, react for 5min, centrifuge to get precipitate, redisperse in In 1 mL of acetonitrile solution, AgZnTPP core-shell nanoparticles were obtained.

[0039] The reaction formula is: ZnTPP ·+ +Ag→ZnTPP+Ag +

[...

Embodiment 2

[0044] 1) 50mg (0.20mmol) perylene (Perylene) was dissolved in 20ml methylene chloride; 204mg (0.80mmol) I 2 Dissolved in 10ml of dichloromethane; 232mg (1.60mmol) AgClO 4 Dissolved in 3ml of acetonitrile; 2 solution of dichloromethane and AgClO 4 The acetonitrile solution of Perylene was added into the dichloromethane solution of Perylene and stirred for 0.5h. The obtained precipitate was centrifuged, washed with dichloromethane and dried, and the acetonitrile was carefully added dropwise over the top. The container was sealed and left for 16 hours. The liquid is the cationic free radical solution of Perylene, and the concentration measured by cetyltrimethylammonium bromide (CTAB) solution is 0.1mmol / L;

[0045] The reaction formula is: Pe+1 / 2I 2 +AgClO 4 →AgI+Pe + ClO 4 -

[0046] 2) Under the condition of sealing, light-blocking and magnetic stirring, add 3ml 0.1mmol / L Pe cationic radical solution into 1ml 5mM Ag nanoparticle acetonitrile suspension in sequence, rea...

Embodiment 3

[0052] 1) Add 1mg (2×10 -6 mol) hexathiophene (Sexithiophene, 6T) was dissolved in 5mL of dichloromethane; 0.8mg (5 × 10 -4 mol) FeCl 3 Dissolve in 5mL dichloromethane; FeCl 3 The dichloromethane solution of 6T is added to the dichloromethane solution of 6T, and the dark blue 10 -6 6T cationic free radical solution of mol / L;

[0053] The reaction formula is: 6T+2FeCl 3 →6T· + +FeCl 4- +FeCl 2

[0054] 2) Under the conditions of sealing, light-blocking and magnetic stirring, 1mL of 10 -6 The mol / L 6T cationic radical solution was sequentially added to 1ml of 5mM Ag nanoparticle acetonitrile suspension, reacted for 5min, centrifuged to obtain a precipitate, and redispersed in mL acetonitrile solution to obtain Ag6T core-shell structure nanoparticles.

[0055] The reaction formula is: 6T ·+ +Ag→Ag + +6T

[0056] 3) Under the condition of magnetic stirring, in the sol of the obtained Ag6T core-shell particles, add the aniline solution of 1ml5mmol / L, the sodium cetylsul...

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Abstract

The invention relates to a water-soluble noble metal/organic fluorescent micro-molecular nuclear shell nanometer material, in particular to a preparation method for a nanometer material with noble metal enhanced organic fluorescent illuminating and raman signal. According to the technical scheme of the invention, the preparation method comprises the following steps of: preparing noble metal nanometer silver (Ag) particles; preparing a cation free radical solution of organic molecules according to a AgClO4 or I2 oxidation method or FeCl3 oxidation method; dropwise adding the cation free radical solution of organic molecules into a suspension of noble metal nanometer particles, and performing replacement reaction on the cation and the noble metal nanometer Ag particles, thereby obtaining noble metal/organic functional micro-molecular nuclear shell structural nanometer particles; and coating a layer of PANI (polyaniline) on the surfaces of the nuclear shell structural nanometer particles, thereby causing the material to possess strong fluorescent performance in water. The preparation method provided by the invention is simple, is easily performed and is utilized to prepare the water-soluble nuclear shell structural nanometer particles with noble metal enhanced fluorescent and raman signal in large scale. According to the preparation method, an excellent material is applied to the aspect of biological imaging, and the like, and the preparation method has wider application prospect.

Description

technical field [0001] The invention relates to a water-soluble Ag / organic fluorescent small molecule core-shell nanomaterial, in particular to a preparation method of a nanomaterial based on noble metal Ag that can enhance organic fluorescein luminescence and Raman signals. Background technique [0002] In recent years, fluorescent nanomaterials are not only used as a research tool in imaging and sensing, but also play an important role in the prevention and monitoring of various clinical diseases, which has attracted extensive attention of researchers at home and abroad. Especially for cell imaging, it requires nanomaterials with high fluorescence quantum yield, stability and biocompatibility, and needs to be small enough (less than 100 nm) to enter cells. Traditional fluorescent dyes are usually small organic molecules, but these dyes are basically insoluble in water and have a single output signal, which greatly limits their application in the biological field. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 孙晓明张新科罗亮
Owner BEIJING UNIV OF CHEM TECH
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