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Anthraquinone derivative, as well as preparation method and application of anthraquinone derivative serving as antibacterial agent

An anthraquinone derivative and post-reaction technology, applied in the field of anthraquinone derivatives, can solve the problems of unseen marine natural selective antibacterial agents and poor selectivity

Inactive Publication Date: 2012-07-25
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the antibacterial agents currently used are mainly broad-spectrum antibacterial preparations with poor selectivity.
In recent years, no marine natural selective antibacterial agent with important antibacterial value has been obtained from marine microorganisms

Method used

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  • Anthraquinone derivative, as well as preparation method and application of anthraquinone derivative serving as antibacterial agent
  • Anthraquinone derivative, as well as preparation method and application of anthraquinone derivative serving as antibacterial agent
  • Anthraquinone derivative, as well as preparation method and application of anthraquinone derivative serving as antibacterial agent

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Embodiment Construction

[0011] Preparation of Compounds of the Invention

[0012] (1) The medium used for the culture of the fungus Nigrospora sp. (HM565952) contains 1.0% glucose (percentage by weight, the same below), 0.1% yeast extract, 0.2% peptone, 1.0% agar, 3% coarse sea salt, and the rest is Water, made into a test tube slant when used, and the fungal strains were cultivated at 30°C for 5 days.

[0013] The strain culture medium contains 0.1%-5.0% of glucose (percentage by weight, the same below), 0.01%-1% of yeast extract, 0.01%-1% of peptone, 0.1%-3.0% of agar, 3% of coarse sea salt, and the rest for water. (2) The fermentation medium used for the fermentation culture of the fungus Nigrospora sp. (HM565952) contains 1.0% glucose (percentage by weight, the same below), 0.1% yeast extract, 0.2% peptone, 3% coarse sea salt, and the rest is water. Cultured at 28°C for 30 days.

[0014] The fermentation medium contains 0.1%-5.0% of glucose (weight percentage, the same below), 0.01%-1% of yeas...

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Abstract

The invention provides an anthraquinone derivative, as well as a preparation method and application of the anthraquinone derivative serving as an antibacterial agent. The preparation method comprises the following steps: culturing a strain of Nigrospora sp. (HM565952) in a strain culture medium; fermenting the nigrospora sp. in a fermentation culture medium; filtering the fermentation broth, removing thallus, and extracting the fermentation broth with ethyl acetate; concentrating the extract, and performing chromatographic separation, and concentrating the eluent to obtain two types of yellow powder, namely 3,5,8-Trihydroxy-7-methoxy-2-methylanthracene-9,10-dione and austrocortirubin; and adding an acetic anhydride reagent in a solution dissolved with the compound, and reacting to obtain the anthraquinone derivative. The anthraquinone derivative obtained from the Nigrospora sp. (HM565952) has selective inhibitory activity to Bacillus subtilis, Bacillus cereus, Micrococcus tetragenus, Micrococcus lutea, Escherichia coli, Staphylococcus aureus, Staphylococcus albus, Vibrio parahaemolyticus and Vibrio anguillarum, and can be used for developing selective bacteriostatic agents; and the raw materials can be produced on a large scale, and not limited by resources. Therefore, the anthraquinone derivative has the advantage of wide application prospect.

Description

technical field [0001] The invention relates to a method for selectively inhibiting Bacillus subtilis, Bacillus cereus, Micrococcus tetragenus, Micrococcus lutea, Escherichia coli , anthraquinone derivatives of Staphylococcus aureus, Staphylococcus albus, and marine bacteria Vibrio parahaemolyticus and Vibrio anguillarum, and preparation methods and applications thereof. Background technique [0002] Bacteria can parasitize the respiratory tract, skin and navel of the human body. When they invade some parts of the human body, they can cause infections, including urinary tract infection, digestive tract infection, lung infection, wound infection, biliary tract infection, peritonitis, sepsis and meningitis, etc. , the symptoms of people after infection are stomach pain, vomiting, diarrhea and fever, and sometimes even fatal to the elderly and children with poor physique. According to the survey of disease classification from 1995 to 2007, infectious diseases accounted for 49%...

Claims

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Application Information

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IPC IPC(8): C07C69/21C07C69/18C12P7/66A61K31/222A61P31/04C12R1/645
CPCA61P31/04C09B1/04
Inventor 邵长伦王长云杨凯琳佘志刚
Owner OCEAN UNIV OF CHINA
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