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Wet composite dressing and sealed negative pressure drainage device therefrom

A technology of negative pressure drainage and wet dressing, which is applied in the field of biomedicine, can solve the problems of high cost, high cost of polyvinyl alcohol, and dependence on imports, and achieve high tensile strength and elastic modulus. The combination process is simple and easy, and the preparation The process is simple and easy to get the effect

Active Publication Date: 2014-04-16
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used dressing material is polyvinyl alcohol, but the cost of polyvinyl alcohol is relatively high, and the manufacturing process of the porous structure is complicated, mainly relying on imports
As a result, the cost of such treatment methods in our country is very high, which increases the heavy economic burden on patients.
In addition, the closed negative pressure drainage devices currently used clinically are generally made by medical institutions using accessories from different manufacturers, which makes the whole system unstable and cannot guarantee the safety during use.
However, most of the closed negative pressure drainage devices produced by imported manufacturers are of fixed specifications and models, which are difficult to meet the needs of different wound positions and are very expensive.

Method used

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  • Wet composite dressing and sealed negative pressure drainage device therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Bacterial cellulose is prepared by Acetobacter xylinum, and the activated strain is placed in the seed medium to obtain a seed solution. The seed medium is 10w / v% glucose, 0.01w / v% calcium carbonate, 0.01w / v% yeast extract and the balance water. The cultured seed solution is inserted into the fermentation medium to obtain bacterial cellulose. The fermentation medium is 3w / v% glucose, 0.1 w / v% disodium hydrogen phosphate, 0.1 w / v% potassium dihydrogen phosphate, 0.1 w / v% yeast extract, 0.1 w / v% peptone and the rest water. Soak bacterial cellulose obtained by fermentation culture in 1% NaOH aqueous solution by mass, heat at 60°C for 6 hours, and then rinse repeatedly with double distilled water until neutral. Remove bacterial protein and residual culture medium adhering to the cellulose membrane.

[0030] (2) Dissolve chitosan with a molecular weight of 50,000 in 0.1% acetic acid solution to prepare a 5% chitosan acetic acid solution. The bacterial cellulose with a...

Embodiment 2

[0033] (1) Bacterial cellulose is prepared from Rhizobium, and the activated strain is placed in the seed medium to obtain a seed solution. The seed medium is 3w / v% glucose, 0.1w / v% calcium carbonate, 0.1w / v% yeast extract and the balance water. The cultured seed solution is inserted into the fermentation medium to obtain bacterial cellulose. The fermentation medium is 10w / v% glucose, 0.4 w / v% disodium hydrogen phosphate, 0.4 w / v% potassium dihydrogen phosphate, 0.5 w / v% yeast extract, 0.5 w / v% peptone and the rest water. Soak the bacterial cellulose obtained by fermentation culture in 2% NaOH aqueous solution by mass, heat at 70°C for 5 hours, and then wash it repeatedly with twice distilled water until neutral. Remove bacterial protein and residual culture medium adhering to the cellulose membrane.

[0034] (2) Dissolve chitosan with a molecular weight of 100,000 in 0.5% acetic acid solution to prepare a 4% chitosan acetic acid solution. The bacterial cellulose with a wat...

Embodiment 3

[0037] (1) Bacterial cellulose is prepared from Sarcina, and the activated strain is placed in the seed medium to obtain a seed solution. The seed medium is 5w / v% glucose, 0.05w / v% calcium carbonate, 0.02w / v% yeast extract and the rest of water. The cultured seed solution is inserted into the fermentation medium to obtain bacterial cellulose. The fermentation medium is 5w / v% glucose, 0.2w / v% disodium hydrogen phosphate, 0.2w / v% potassium dihydrogen phosphate, 0.2w / v% yeast extract, 0.2w / v% peptone and the rest of water. Soak bacterial cellulose obtained through fermentation culture in 3% NaOH aqueous solution by mass, heat at 80°C for 4 hours, and then rinse repeatedly with twice distilled water until neutral. Remove bacterial protein and residual culture medium adhering to the cellulose membrane.

[0038] (2) Dissolve chitosan with a molecular weight of 150,000 in 1% acetic acid solution to prepare a 3% chitosan acetic acid solution. The bacterial cellulose with a water ma...

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Abstract

The invention discloses a wet composite dressing and a sealed negative pressure drainage device therefrom, which relate to a medical product. The sealed negative pressure drainage device comprises a wet bacterial cellulose-chitosan fiber composite dressing, an adhesive semipermeable membrane, a negative pressure plate and a drainage tube connected with a negative pressure device. The negative pressure drainage device disclosed by the invention has the advantages of low cost and simpleness and easiness in preparation process and is convenient to operate. The whole device can be cut and combined at will according to the shape and the position of a wound surface, has multiple functions of antibiosis, moisture retention and negative-pressure drainage, can be used for curing chronic and unhealed wound, acute intractable wounds, burns and large-area soft tissue defects and / or infections.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a wet composite dressing and a closed negative pressure drainage device prepared therefrom. Specifically, a bacterial cellulose composite chitosan fiber wet dressing with moisturizing and drainage functions is obtained by electrospinning, and is combined with a semipermeable membrane, a negative pressure plate and a drainage tube connected to a negative pressure device. Closed negative pressure drainage device. Background technique [0002] Wound sealing negative pressure drainage technology (vacuum sealing drainage VSD) is a new wound treatment technology developed in this year. It uses an adhesive semi-permeable membrane to seal the open wound, uses a negative pressure device to generate a certain negative pressure, acts on the wound after debridement through a porous dressing, absorbs the wound exudate and flows out through the drainage tube. In 1992, Dr. Fleischmann et ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/02A61M27/00A61L15/28
Inventor 钟春燕
Owner 钟春燕